Donald J. Hagler
University of California, San Diego
AnatomyInternal medicineRadiologySurgeryMagnetic resonance imagingDiffusion MRIPsychologyCardiologyNeuroscienceCognitionHemodynamicsCardiac catheterizationVentricleHeart diseasePercutaneousPulmonary arteryTemporal lobeWhite matterBrain mappingMagnetoencephalographyNeuroimagingMedicineBiology
Publications 441
#1Kristina M. Rapuano (Yale University)H-Index: 12
#2Jennifer S. Laurent (UVM: University of Vermont)H-Index: 8
Last. Richard Watts (Yale University)H-Index: 40
view all 9 authors...
The prevalence of obesity in children and adolescents worldwide has quadrupled since 1975 and is a key predictor of obesity later in life. Previous work has consistently observed relationships between macroscale measures of reward-related brain regions (e.g., the nucleus accumbens [NAcc]) and unhealthy eating behaviors and outcomes; however, the mechanisms underlying these associations remain unclear. Recent work has highlighted a potential role of neuroinflammation in the NAcc in animal models ...
2 CitationsSource
#1Michael V. Lombardo (IIT: Istituto Italiano di Tecnologia)H-Index: 55
#2Lisa T. Eyler (UCSD: University of California, San Diego)H-Index: 47
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
view all 16 authors...
Cortical regional identities develop through anterior-posterior (A-P) and dorsal-ventral (D-V) prenatal genomic patterning gradients. Here we find that A-P and D-V genomic patterning of cortical surface area (SA) and thickness (CT) is intact in typically developing and autistic toddlers with good language outcome, but is absent in autistic toddlers with poor early language outcome. Genes driving this effect are prominent in midgestational A-P and D-V gene expression gradients and prenatal cell t...
1 CitationsSource
#1Carol E. Franz (UCSD: University of California, San Diego)H-Index: 49
#2Sean N. Hatton (UCSD: University of California, San Diego)H-Index: 22
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 71
view all 20 authors...
Posttraumatic stress disorder (PTSD) is known to persist, eliciting early medical co-morbidity, and accelerated aging. Although PTSD diagnosis has been found to be associated with smaller volume in multiple brain regions, posttraumatic stress (PTS) symptoms and their associations with brain morphometry are rarely assessed over long periods of time. We predicted that persistent PTS symptoms across ~24 years would be inversely associated with hippocampal, amygdala, anterior cingulate volumes, and ...
6 CitationsSource
#1Hugh Garavan (UVM: University of Vermont)H-Index: 90
#2Sage Hahn (UVM: University of Vermont)H-Index: 2
Last. Alexandra Potter (UVM: University of Vermont)H-Index: 24
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This paper responds to a recent critique by Bissett and colleagues ( of the fMRI Stop task being used in the Adolescent Brain Cognitive Development (ABCD) study. The critique focuses primarily on a design feature of the task that the authors contend might lead to a violation of race model assumptions (i.e., that the Go and Stop processes are fully independent) which are relevant to the calculation of the Stop Signal Reaction Time, a mea...
5 CitationsSource
#1Solveig Næss (NMBU: Norwegian University of Life Sciences)
#1Solveig Næss (NMBU: Norwegian University of Life Sciences)H-Index: 5
Last. Torbjørn V. Ness (NMBU: Norwegian University of Life Sciences)H-Index: 12
view all 7 authors...
Electroencephalography (EEG) and magnetoencephalography (MEG) are among the most important techniques for non-invasively studying cognition and disease in the human brain. These signals are known to originate from cortical neural activity, typically described in terms of current dipoles. While the link between cortical current dipoles and EEG/MEG signals is relatively well understood, surprisingly little is known about the link between different kinds of neural activity and the current dipoles t...
#1Monica D. Rosenberg (Yale University)H-Index: 25
#2Steven A. Martinez (Yale University)H-Index: 1
Last. B. J. Casey (Yale University)H-Index: 108
view all 16 authors...
Working memory function changes across development and varies across individuals. The patterns of behavior and brain function that track individual differences in working memory during human development, however, are not well understood. Here we establish associations between working memory, cognitive abilities, and functional MRI activation in data from over 11,500 9–11-year-old children (both sexes) enrolled in the Adolescent Brain Cognitive Development study, an ongoing longitudinal study in ...
6 CitationsSource
#1Talha Niaz (Mayo Clinic)H-Index: 8
#2Susan M. Fernandes (Stanford University)H-Index: 33
Last. Donald J. Hagler (Mayo Clinic)H-Index: 89
view all 5 authors...
Abstract Bicuspid aortic valve (BAV) is one of the most common congenital heart defects in children, adolescents and adults. BAV can occur as an isolated lesion or in association with other congenital heart defects, such as coarctation of the aorta or genetic syndromes like Turner syndrome. Although the majority of long term complications associated with BAV manifest later in life, children and adolescents may present with early onset valvular dysfunction or dilation of the aorta. BAV is a heter...
1 CitationsSource
#1Pradyumna Agasthi (Mayo Clinic)H-Index: 6
#2Sai Harika Pujari (Mayo Clinic)H-Index: 1
Last. Reza Arsanjani (Mayo Clinic)H-Index: 21
view all 9 authors...
Coarctation of the aorta (CoA) is a relatively common congenital cardiac defect often causing few symptoms and therefore can be challenging to diagnose. The hallmark finding on physical examination is upper extremity hypertension, and for this reason, CoA should be considered in any young hypertensive patient, justifying measurement of lower extremity blood pressure at least once in these individuals. The presence of a significant pressure gradient between the arms and legs is highly suggestive ...
Most (87.6%) of residual atrial L-R shunts after Gore Cardioform septal occluder implant disappear by 12 months. Residual leaks at implantation were more common in larger defects with smaller retro-aortic rims, and multiple fenestrations. While most residual defects close in 12 months, we unfortunately do not yet have a clear idea why or which of the 13% do not close.
#1Muhammad Yasir Qureshi (Mayo Clinic)H-Index: 10
#2Nathaniel W. Taggart (Mayo Clinic)H-Index: 14
Last. Timothy J. Nelson (Mayo Clinic)H-Index: 38
view all 10 authors...
The increased workload on single right ventricle (sRV) leads to increased risk of Fontan failure due to ventricular dysfunction. Conventional heart failure therapy has mixed results. This has led to increased interest in seeking alternative therapeutic strategies to improve ventricular function