Donald J. Hagler
Mayo Clinic
AnatomyInternal medicineRadiologySurgeryMagnetic resonance imagingPsychologyCardiologyNeuroscienceCognitionHemodynamicsCardiac catheterizationVentricleHeart diseasePercutaneousPulmonary arteryTemporal lobeWhite matterBrain mappingMagnetoencephalographyMedicineBiology
455Publications
88H-index
20.5kCitations
Publications 449
Newest
#1Richard Q. Loi (UCSD: University of California, San Diego)H-Index: 4
#2Kelly M. Leyden (UCSD: University of California, San Diego)H-Index: 10
Last. Carrie R. McDonald (UCSD: University of California, San Diego)H-Index: 38
view all 9 authors...
SummaryObjective Diffusion tensor imaging (DTI) has become a popular tool for delineating the location and extent of white matter injury in temporal lobe epilepsy (TLE). However, DTI yields nonspecific measures that are confounded by changes occurring within both the intracellular and extracellular environments. This study investigated whether an advanced diffusion method, restriction spectrum imaging (RSI) could provide a more robust measure of white matter injury in TLE relative to DTI due to ...
9 CitationsSource
#1Hana Uhlirova (UCSD: University of California, San Diego)H-Index: 6
#2Kıvılcım Kılıç (UCSD: University of California, San Diego)H-Index: 13
Last. Anna Devor (UCSD: University of California, San Diego)H-Index: 38
view all 23 authors...
The computational properties of the human brain arise from an intricate interplay between billions of neurons connected in complex networks. However, our ability to study these networks in healthy human brain is limited by the necessity to use non-invasive technologies. This is in contrast to animal models where a rich, detailed view of cellular-level brain function with cell-type-specific molecular identity has become available due to recent advances in microscopic optical imaging and genetics....
32 CitationsSource
#1Mohamad Alkhouli (Mayo Clinic)H-Index: 24
#2Abdallah El Sabbagh (Mayo Clinic)H-Index: 13
Last. Mackram F. Eleid (Mayo Clinic)H-Index: 33
view all 6 authors...
Significant residual mitral regurgitation (MR) may persist after MitraClip (Abbott Vascular, Santa Clara, California) implantation in up to 7% of patients with degenerative MR [(1)][1]. Treatment of the residual MR with an adjacent MitraClip may not be feasible, because of commissural location,
3 CitationsSource
Key Points: Current delivery systems for the Sapien XT valve for the native pulmonary valve are unacceptable stiff and poorly design for implantation in the pulmonary outflow tract. This report details improvisation of the Melody Ensemble for easier pulmonary outflow tract delivery of the Sapien XT valve. The unacceptable cost of the utilization of two delivery systems for valve implantation, requires industry development of an safe, effective delivery system appropriate for the pulmonary outflo...
Source
#1Kristine B. Walhovd (University of Oslo)H-Index: 75
#2Stine K. Krogsrud (University of Oslo)H-Index: 10
Last. Anders M. Fjell (University of Oslo)H-Index: 76
view all 22 authors...
Neurodevelopmental origins of functional variation in older age are increasingly being acknowledged, but identification of how early factors impact human brain and cognition throughout life has rem ...
102 CitationsSource
#1Jeremy A. Elman (UCSD: University of California, San Diego)H-Index: 15
#2Matthew S. Panizzon (UCSD: University of California, San Diego)H-Index: 35
Last. William S. Kremen (UCSD: University of California, San Diego)H-Index: 70
view all 11 authors...
Source
#1Erik Newman (UCSD: University of California, San Diego)H-Index: 10
#2Wesley K. Thompson (UCSD: University of California, San Diego)H-Index: 68
Last. Terry L. Jernigan (UCSD: University of California, San Diego)H-Index: 101
view all 27 authors...
Anxiety is a risk factor for many adverse neuropsychiatric and socioeconomic outcomes, and has been linked to functional and structural changes in the ventromedial prefrontal cortex (VMPFC). However, the nature of these differences, as well as how they develop in children and adolescents, remains poorly understood. More effective interventions to minimize the negative consequences of anxiety require better understanding of its neurobiology in children. Recent research suggests that structural im...
29 CitationsSource
#1Chun C. Fan (UCSD: University of California, San Diego)H-Index: 8
#1Chun Chieh Fan (UCSD: University of California, San Diego)H-Index: 26
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 166
view all 8 authors...
Williams Syndrome (WS), a rare genetic disorders caused by hemizyous deletion of ~26 genes on the chromosome 7, has unique cognitive features and neuroanatomic abnormalities. Limited in statistical power due to its rareness had led to inconsistent in many direct comparisons using structural magnetic resonance imaging (MRI), and their associations with cognitive features of WS are not clear. Here, we used a novel approach to derive a WS specific neuroarchitectural profile and tested its associati...
Source
#1Niclas Pettersson (UCSD: University of California, San Diego)H-Index: 13
#2Roshan Karunamuni (UCSD: University of California, San Diego)H-Index: 15
Last. Laura Cervino (UCSD: University of California, San Diego)H-Index: 22
view all 15 authors...
Purpose: We investigated predictors of fractional anisotropy (FA) change in the corticospinal white matter tract (CST) following radiation therapy (RT). Methods: Diffusion tensor imaging (DTI) is a non-invasive modality which models water diffusion properties. FA quantifies the extent of directional bias—a decrease indicates disrupted white matter integrity. Fifteen patients with high-grade glioma underwent DTI scans before, and ten months after RT to 59.4–60 Gy. The CST was segmented using an a...
Source
#1Stephanie Solso (UCSD: University of California, San Diego)H-Index: 5
#2Ronghui Xu (UCSD: University of California, San Diego)H-Index: 27
Last. Eric Courchesne (UCSD: University of California, San Diego)H-Index: 116
view all 12 authors...
Abstract Background Theories of brain abnormality in autism spectrum disorder (ASD) have focused on underconnectivity as an explanation for social, language, and behavioral deficits but are based mainly on studies of older autistic children and adults. Methods In 94 ASD and typical toddlers ages 1 to 4 years, we examined the microstructure (indexed by fractional anisotropy) and volume of axon pathways using in vivo diffusion tensor imaging of fronto-frontal, fronto-temporal, fronto-striatal, and...
75 CitationsSource