Shinyu Izumi
Nagasaki University
Internal medicineRadiologySurgeryPathologyRetrospective cohort studyIntensive care medicineImmunologyBronchial thermoplastyRespiratory failureExacerbationLungPneumoniaIdiopathic pulmonary fibrosisDiseaseCoronavirus disease 2019 (COVID-19)Influenza A virus subtype H5N1MedicineBiologyPandemicGastroenterology
111Publications
19H-index
1,149Citations
Publications 108
Newest
#1Akinari TsukadaH-Index: 1
#2Manabu SuzukiH-Index: 5
Last. Haruhito SugiyamaH-Index: 19
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We herein report a 67-year-old kidney transplant patient who died of COVID-19. He was treated with hydroxychloroquine and azithromycin and received mechanical ventilation that temporarily improved his respiratory status. Despite our efforts, however, he later developed respiratory failure and died 43 days after the disease onset. The autopsy revealed prominent organization of alveoli and alveolar ducts, with a massive accumulation of macrophages in the lungs. A few SARS-CoV-2 antigen-positive ce...
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#1Shu Hisata (Jichi Medical University)H-Index: 10
#2Masashi Bando (Jichi Medical University)H-Index: 22
Last. Naohiko Inase (Tokyo Medical and Dental University)H-Index: 27
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Abstract Background Phase IV clinical trials in Western countries have reported that combined therapy with pirfenidone and nintedanib for idiopathic pulmonary fibrosis (IPF) has a manageable safety profile. However, data on the long-term safety and tolerability of this combination treatment in the real-world setting in Japan are limited. Methods The retrospective data of 46 patients with IPF who received combination therapy with pirfenidone and nintedanib were obtained from 16 institutes in Japa...
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#1Sho SaitoH-Index: 7
#2Kayoko HayakawaH-Index: 4
Last. Norio OhmagariH-Index: 7
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Coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) originating in Wuhan, China, has spread globally very rapidly. The number of COVID-19 patients increased in Japan from late March to early April 2020. Since COVID-19 treatment methods with antiviral drugs were not established in March 2020, clinical trials began at a rapid pace worldwide. We participated in a global investigator-initiated clinical trial of the antiviral drug remdesivir. It took...
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#1Yoshie TsujimotoH-Index: 2
#2Junko TeradaH-Index: 1
Last. Haruhito SugiyamaH-Index: 19
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BACKGROUND: The current gold standard in coronavirus disease (COVID-19) diagnostics is the real-time reverse transcription-polymerase chain reaction (RT-PCR) assay for detecting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in nasopharyngeal swab (NPS) samples. Alternatively, nasal swab (NS) or saliva swab (SS) specimens are used, although available data on test accuracy are limited. We examined the diagnostic accuracy of NPS/NS/SS samples for this purpose. METHODS: Ten patien...
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#1Hiroshi TakumidaH-Index: 2
#2Shinyu IzumiH-Index: 19
Last. Masayuki HojoH-Index: 11
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Abstract A 70-year-old Japanese man contracted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and required oxygen to maintain oxygen saturation (>90%), 5 weeks after onset of coronavirus disease 2019 (COVID-19) symptoms. Transbronchial lung cryobiopsy revealed pathological features of organizing pneumonia with alveolar epithelial injury, and prednisolone administration led to alleviation of respiratory symptoms and recovery of respiratory function. This case report is the...
1 CitationsSource
#1Masaya SugiyamaH-Index: 34
#2Noriko KinoshitaH-Index: 6
Last. Masashi MizokamiH-Index: 97
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COVID-19, a novel coronavirus-related illness, has spread worldwide. Patients with apparently mild/moderate symptoms can suddenly develop severe pneumonia. Therefore, almost all COVID-19 patients require hospitalization, which can reduce limited medical resources in addition to overwhelming medical facilities. To identify predictive markers for the development of severe pneumonia, a comprehensive analysis of serum chemokines and cytokines was conducted using serial serum samples from COVID-19 pa...
8 CitationsSource
#1Seik-Soon KhorH-Index: 13
#2Yosuke OmaeH-Index: 12
Last. Katsushi TokunagaH-Index: 93
view all 13 authors...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing coronavirus disease 2019 (COVID-19) was announced as an outbreak by the World Health Organization (WHO) in January 2020 and as a pandemic in March 2020. The majority of infected individuals have experienced no or only mild symptoms, ranging from fully asymptomatic cases to mild pneumonic disease. However, a minority of infected individuals develop severe respiratory symptoms. The objective of this study was to identi...
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#1Satoru IshiiH-Index: 6
#2Hiromu WatanabeH-Index: 1
Last. Masayuki HojoH-Index: 11
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OBJECTIVE New flex-rigid pleuroscope enables observations with a maximum angle of curvature of 180° , allowing visualization of the area near the insertion site of the pleuroscope. And, it improved the image quality and channel inner diameter. The aim of this study was to evaluate the clinical effectiveness and safety of a new flex-rigid pleuroscope. METHODS A retrospective analysis of patients who were examined with a new flex-rigid pleuroscope under local anesthesia at our institution was cond...
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#2Motoyasu IikuraH-Index: 21
Last. Masao HashimotoH-Index: 8
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Bronchial thermoplasty (BT) is an interventional endoscopic treatment for severe bronchial asthma. Some studies have shown the clinical efficacy of this intervention, but its cost-effectiveness is unclear. The aim of this study was to evaluate the cost-effectiveness of BT. We collected data from the medical records of 16 Japanese patients who were treated with BT between February 2015 and April 2017, and compared asthma-related medical expenses between the year preceding and the year following B...
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OBJECTIVE: To evaluate the efficacy and safety of direct hemoperfusion using a polymyxin B-immobilized polystyrene column (PMX-DHP) in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive pneumonia patients. METHODS: This study was a case series conducted at a designated infectious diseases hospital. Twelve SARS-CoV-2-positive patients with partial pressure of arterial oxygen/percentage of inspired oxygen (P/F) ratio < 300 were treated with PMX-DHP on two consecutive days each d...
1 CitationsSource