Javier Crespo
Carlos III Health Institute
Internal medicineEndocrinologySurgeryVirologyImmunologyHepatitis C virusHepatitis CLiver diseaseCirrhosisFatty liverDiseaseSteatohepatitisLiver transplantationRibavirinFibrosisIn patientNon alcoholicChronic hepatitisMedicineBiologyGastroenterology
472Publications
43H-index
8,200Citations
Publications 464
Newest
#2Javier CrespoH-Index: 43
Last. Manuel Morales Ruiz (University of Barcelona)H-Index: 1
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INTRODUCTION AND AIM Non-malignant portal vein thrombosis (PVT) is a complication of liver cirrhosis. The aim of this study was to evaluate the annual incidence of PVT and related risk factors. METHODS We retrospectively reviewed clinical, laboratory and radiological data collected prospectively from September 2016 to September 2017. A follow-up of 36 months was performed in a subset of patients to determine the cumulative incidence of PVT and related complications. RESULTS The study included 56...
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#1Lina Badimon (ISCIII: Carlos III Health Institute)H-Index: 99
#1Lina Badimon (ISCIII: Carlos III Health Institute)H-Index: 2
Last. Maria Borrell-Pages (ISCIII: Carlos III Health Institute)H-Index: 2
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AIMS Atherosclerosis, the leading cause of cardiovascular diseases, is driven by high blood cholesterol levels and chronic inflammation. Low-Density Lipoprotein Receptor (LDLR) play a critical role in regulating blood cholesterol levels by binding to and clearing LDLs from the circulation. The disruption of the interaction between Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) and LDLR reduces blood cholesterol levels. It is not well known whether other members of the LDLR superfamily may be t...
10 CitationsSource
#1Aureli LuqueroH-Index: 1
#2Gemma Vilahur (ISCIII: Carlos III Health Institute)H-Index: 49
Last. Maria Borrell-Pages (ISCIII: Carlos III Health Institute)H-Index: 8
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Microvesicles (MV) contribute to cell-to-cell communication through their transported proteins and nucleic acids. MV, released into the extracellular space, exert paracrine regulation by modulating cellular responses after interaction with near and far target cells. MV are released at high concentrations by activated inflammatory cells. Different subtypes of human macrophages have been characterized based on surface epitopes being CD16+ macrophages associated with anti-inflammatory phenotypes. W...
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#2Javier CrespoH-Index: 43
Last. Manuel Morales Ruiz (University of Barcelona)H-Index: 1
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#1Jeffrey V. Lazarus (University of Barcelona)H-Index: 42
#2Quique BassatH-Index: 66
Last. Miquel Oliu-Barton (Paris Dauphine University)
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During the first five months of 2021, Spain’s COVID-19 vaccination campaign progressed slowly and failed to reach marginalised populations. Here, we discuss how, despite recent improvements, it remains important to further engage key stakeholders to ensure nobody is left behind. Lazarus et al. outline the barriers slowing down the COVID-19 vaccination campaign in Spain. They issue a call to action for all stakeholders to improve access to vaccines, with a particular emphasis on reaching marginal...
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#2Jorge Simón (ISCIII: Carlos III Health Institute)H-Index: 10
Last. Maria Mercado-GómezH-Index: 3
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Abstract null null Objective null Neddylation is a druggable and reversible ubiquitin-like post-translational modification upregulated in many diseases, including liver fibrosis, hepatocellular carcinoma, and more recently, non-alcoholic fatty liver disease (NAFLD). Herein, we propose to address the effects of neddylation inhibition and the underlying mechanisms in pre-clinical models of NAFLD. null null null Methods null Hepatic neddylation measured by immunohistochemical analysis and NEDD8 ser...
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#2Joaquín CabezasH-Index: 14
Last. Maria Buti (ISCIII: Carlos III Health Institute)H-Index: 80
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BACKGROUND AND AIMS Transient elastography (TE) to estimate liver stiffness has proved to be very useful in the diagnosis of chronic liver disease. Here, we intend to evaluate its use in a large Spanish cohort. METHOD Nested study within the PREVHEP-ETHON (Epidemiological sTudy of Hepatic infectiONs; NCT02749864) population-based, cross-sectional study performed between July 2015 and April 2017. An epidemiological questionnaire, laboratory tests and TE and anthropometric measurements were obtain...
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#1Javier Crespo (ISCIII: Carlos III Health Institute)H-Index: 43
#2Carlos Fernández Carrillo (ISCIII: Carlos III Health Institute)H-Index: 5
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Background and aim Significant human and material resources have been diverted to COVID-19. Healthcare workers are at high risk of SARS-CoV-2 infection. We assess the impact of the COVID-19 pandemic on Gastroenterology and Hepatology departments and specialists in Spain. Methods Nationwide survey addressing the impact of COVID-19 on resources, procedures and physicians of Gastroenterology and Hepatology departments in 81 hospitals representative of the Spanish National Health Service. Results Ov...
3 CitationsSource