Lanjing Zhang
Rutgers University
EpidemiologyCancerInternal medicinePathologyOncologyRandom forestImmunohistochemistryMetastasisStem cellPopulationCoronavirus disease 2019 (COVID-19)Incidence (epidemiology)Cancer researchProportional hazards modelColorectal cancerBreast cancerMedicineBiologyGastroenterologyCell biology
134Publications
20H-index
4,073Citations
Publications 95
Newest
#1Kevin Tong (RU: Rutgers University)H-Index: 4
#2Om A. Kothari (RU: Rutgers University)H-Index: 1
Last. Jinchuan Xing (RU: Rutgers University)H-Index: 50
view all 13 authors...
BRAF-driven colorectal cancer is among the poorest prognosis subtypes of colon cancer. Previous studies suggest that BRAF-mutant serrated cancers frequently exhibit Microsatellite Instability (MSI) and elevated levels of WNT signaling. The loss of tumor-suppressor Smad4 in oncogenic BRAF-V600E mouse models promotes rapid serrated tumor development and progression, and SMAD4 mutations co-occur in human patient tumors with BRAF-V600E mutations. This study assesses the role of SMAD4 in early-stage ...
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#1Evelien Schaafsma (Dartmouth College)H-Index: 7
#2Baoyi Zhang (Rice University)H-Index: 1
Last. Chao ChengH-Index: 47
view all 6 authors...
Background null The Oncotype DX breast recurrence score has been introduced more than a decade ago to aid physicians in determining the need for systemic adjuvant chemotherapy in patients with early-stage, estrogen receptor (ER)+, lymph node-negative breast cancer. null Methods null In this study, we utilized data from The Surveillance, Epidemiology, and End Results (SEER) Program to investigate temporal trends in Oncotype DX usage among US breast cancer patients in the first decade after the in...
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#1Mu Yang (Princeton University)H-Index: 4
#2Xin Hu (Yale University)H-Index: 1
Last. Shi Wei (UAB: University of Alabama at Birmingham)H-Index: 27
view all 11 authors...
Relative survival is the ratio of overall survival (OS) over survival of the general population, and widely used in epidemiological studies. But it is artificially higher than OS and thus inferior to OS for cancer prognostication of individual patients. Moreover, trend-changes and disparities in OS of breast cancer are unclear while the relative survival of breast cancer has been reported on a regular basis. Therefore, we estimated trends in age-standardized 5-year OS of invasive breast cancer, ...
The role of p53 in tumor suppression has been extensively studied and well-established. However, the role of p53 in parasitic infections and the intestinal type 2 immunity is unclear. Here, we report that p53 is crucial for intestinal type 2 immunity in response to the infection of parasites, such as Tritrichomonas muris and Nippostrongylus brasiliensis. Mechanistically, p53 plays a critical role in the activation of the tuft cell-IL-25-type 2 innate lymphoid cell circuit, partly via transcripti...
1 CitationsSource
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Although annual mortality trends for prostate cancer were stabilized in recent years, understanding the exact treatment changes is necessary for optimal management. Utilization of not-otherwise specified (NOS) treatments for prostate cancer was unclear. Thus, this study aimed to analyze trends in treatment for prostate cancer in the U.S. from 2010 to 2015 and examine whether the treatment for the prostate cancer in the U.S. is compliant with clinical practice guidelines. Using joinpoint regressi...
#1Baoyi Zhang (Rice University)H-Index: 1
#2Kevin Yao (A&M: Texas A&M University)
Last. Chao Cheng (BCM: Baylor College of Medicine)H-Index: 47
view all 5 authors...
Colorectal cancer (CRC) is the third leading cause of cancer-related death in the US. About 15% of CRCs are associated with microsatellite instability (MSI) due to loss of function in the DNA mismatch repair pathway. This subgroup of patients has better survival rates and is more sensitive to immunotherapy. However, it remains unclear whether microsatellite stable (MSS) CRC patients can be further stratified into subgroups with differential clinical characteristics. In this study, we analyzed Th...
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#1Fei Deng (Shanghai Institute of Technology)H-Index: 2
#2Jibing Huang (Shanghai Institute of Technology)H-Index: 2
Last. Lanjing ZhangH-Index: 20
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Most biomedical datasets, including those of ‘omics, population studies, and surveys, are rectangular in shape and have few missing data. Recently, their sample sizes have grown significantly. Rigorous analyses on these large datasets demand considerably more efficient and more accurate algorithms. Machine learning (ML) algorithms have been used to classify outcomes in biomedical datasets, including random forests (RF), decision tree (DT), artificial neural networks (ANN), and support vector mac...
2 CitationsSource
#1Fei Deng (Shanghai Institute of Technology)
#2Haijun Zhou (Houston Methodist Hospital)H-Index: 1
Last. Lanjing ZhangH-Index: 20
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BACKGROUND Random forests (RF) is a widely used machine-learning algorithm, and outperforms many other machine learning algorithms in prediction-accuracy. But it is rarely used for predicting causes of death (COD) in cancer patients. On the other hand, multicategory COD are difficult to classify in lung cancer patients, largely because they have multiple labels (versus binary labels). METHODS We tuned RF algorithms to classify 5-category COD among the lung cancer patients in the surveillance, ep...
3 CitationsSource
#1Jieliang Li (RU: Rutgers University)H-Index: 1
#2Luong Huynh (RU: Rutgers University)H-Index: 1
Last. He Wang (RU: Rutgers University)H-Index: 58
view all 15 authors...
Objective: Electronic cigarette (e-cig) use has recently been implicated in promoting atherosclerosis. In this study, we aimed to investigate the mechanism of e-cig exposure accelerated atheroscler...
2 CitationsSource