Christopher J.M. Williams
University of Leeds
Quality of lifeParametric statisticsPsychiatryPsychopathologyInternal medicineUrologyMental healthPublic healthAssociation (psychology)Artificial intelligencePsychologyHealth careCognitionIntensive care medicineCognitive psychologyPhysical therapyImmunologyImmunohistochemistryMental illnessStatement (logic)SomatizationPsychosomaticsEpiregulinInflammatory bowel diseaseIrritable bowel syndromeCalprotectinPanitumumabProduction (economics)Urinary incontinencePsychiatric hospitalHospital Anxiety and Depression ScaleFaecal calprotectinDepression (differential diagnoses)SupervisorDiseaseComorbidityCrohn's diseaseMEDLINEPsychosisResponse Evaluation Criteria in Solid TumorsIrinotecanPrimary tumorProtocol (science)Ulcerative colitisIntervention (counseling)MoodAmphiregulinBrain damageSomatisation disorderActive inflammationPopulationMucosal inflammationEthical issuesClinical decision makingGeneral hospitalClinical diseaseCognitive behaviourClinical courseIn patientService userCase noteFunctional psychosisPoor correlationOutpatient clinicCase findingDescriptive statisticsFocus (computing)Family medicineColorectal cancerMedical diagnosisPositive predicative valueManagement sciencePsychotherapistAnxietyPoint-of-care testingMedicineBiomarker (medicine)Gastroenterology
15Publications
4H-index
145Citations
Publications 15
Newest
#1Christopher J.M. Williams (University of Leeds)H-Index: 4
#2Jenny F. Seligmann (University of Leeds)H-Index: 8
Last. Kandavel Shanmugam (Ventana Medical Systems)H-Index: 9
view all 27 authors...
Purpose High tumor mRNA levels of the EGFR ligands, amphiregulin (AREG) and epiregulin (EREG) are associated with anti-EGFR agent response in metastatic colorectal cancer (mCRC). However, ligand RNA assays have not been adopted into routine practice due to issues with analytical precision and practicality. We investigated whether AREG/EREG immunohistochemistry (IHC) could predict benefit from the anti-EGFR agent, panitumumab. Experimental Design Artificial intelligence algorithms were developed ...
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#1Y. Derwa (University of Leeds)H-Index: 4
#2Christopher J.M. Williams (University of Leeds)H-Index: 4
Last. David J. Gracie (University of Leeds)H-Index: 16
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Objectives: Patient-reported symptoms correlate poorly with mucosal inflammation. Clinical decision-making may, therefore, not be based on objective evidence of disease activity. We conducted a study to determine factors associated with clinical decision-making in a secondary care inflammatory bowel disease (IBD) population, using a cross-sectional design. Methods: Decisions to request investigations or escalate medical therapy were recorded from outpatient clinic encounters in a cohort of 276 p...
12 CitationsSource
#1David J. Gracie (University of Leeds)H-Index: 16
#2Christopher J.M. Williams (St James's University Hospital)H-Index: 4
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 7 authors...
Background & Aims Symptoms compatible with irritable bowel syndrome (IBS) are common in patients with inflammatory bowel disease (IBD), but it is unclear whether this relates to occult IBD activity. We attempted to resolve this issue in a secondary care population by using a cross-sectional study design. Methods We analyzed Rome III IBS symptoms, disease activity indices, and psychological, somatization, and quality of life data from 378 consecutive, unselected adult patients with IBD seen in cl...
46 CitationsSource
#1Y. Derwa (St James's University Hospital)H-Index: 4
#2David J. Gracie (University of Leeds)H-Index: 16
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 8 authors...
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#1Bharati Kochar (UNC: University of North Carolina at Chapel Hill)H-Index: 11
#1David J. GracieH-Index: 16
Last. Robert S. Sandler (UNC: University of North Carolina at Chapel Hill)H-Index: 103
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To the Editor: We thank Drs Levenstein and Prantera for their insightful comments in response to our recently published manuscript (1,2). Our assertions were that clinical disease activity indices were poor predictors of mucosal inflammation in Crohn’s disease (CD) and only modest predictors of mucosal inflammation in ulcerative colitis, and that the presence of symptoms, independent of active inflammation, was associated with psychological comorbidity.
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#1David J. Gracie (St James's University Hospital)H-Index: 16
#2Christopher J.M. Williams (St James's University Hospital)H-Index: 4
Last. Alexander C. Ford (St James's University Hospital)H-Index: 86
view all 7 authors...
Poor Correlation Between Clinical Disease Activity and Mucosal Inflammation, and the Role of Psychological Comorbidity, in Inflammatory Bowel Disease
69 CitationsSource
#1David J. Gracie (University of Leeds)H-Index: 16
#2Christopher J.M. Williams (St James's University Hospital)H-Index: 4
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 7 authors...
Introduction The prevalence of symptoms compatible with irritable bowel syndrome (IBS) in inflammatory bowel disease (IBD) has been previously described.1However, the association between the presence of these symptoms and occult disease activity is less well known, as is the effect of these symptoms on psychological health. We conducted a cross-sectional survey examining these issues. Method Demographic and gastrointestinal symptom data were collected from 439 adult patients via the Rome III que...
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#1David J. Gracie (University of Leeds)H-Index: 16
#2Christopher J.M. Williams (St James's University Hospital)H-Index: 4
Last. Alexander C. Ford (University of Leeds)H-Index: 86
view all 7 authors...
Introduction The Harvey-Bradshaw index (HBI) and simple clinical colitis activity index (SCCAI) are clinical scoring systems used to estimate Crohn’s disease (CD), and ulcerative colitis (UC) activity, respectively. However, whether they are superior to the patient’s own opinion at predicting disease activity, defined by faecal biomarkers of inflammatory bowel disease (IBD) activity is unclear. We conducted a cross-sectional survey of IBD patients to assess these issues. Method Patient opinion a...
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#1Victoria WarrenH-Index: 1
#2Amer F. RehmanH-Index: 1
Last. Christian P. SelingerH-Index: 25
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#1Victoria WarrenH-Index: 1
#2Amer F. RehmanH-Index: 1
Last. Christian P. SelingerH-Index: 25
view all 9 authors...
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