Marcela A. Ferrada
National Institutes of Health
AirwayInternal medicineSomatic cellPathologyDermatologyPediatricsCohort studyImmunologyObservational studyFEV1/FVC ratioVasculitisAsthmaRelapsing polychondritisSubglottic stenosisTracheomalaciaDiseaseUBA1ChondritisGranulomatosis with polyangiitisEar infectionRheumatic diseaseMedicineCohortPandemicGastroenterology
25Publications
5H-index
104Citations
Publications 22
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#1Marcela A. Ferrada (NIH: National Institutes of Health)H-Index: 5
#2Keith A. Sikora (NIH: National Institutes of Health)H-Index: 5
Last. Peter C. Grayson (NIH: National Institutes of Health)H-Index: 25
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OBJECTIVE Somatic mutations in ubiquitin activating enzyme 1 (UBA1) cause a newly defined syndrome known as VEXAS. More than fifty percent of patients currently identified with VEXAS meet diagnostic criteria for relapsing polychondritis (RP). Clinical features that characterize VEXAS within a cohort of RP have not been defined. METHODS Exome and targeted sequencing of the UBA1 gene was performed in a prospective observational cohort of patients with RP. Clinical and immunological characteristics...
1 CitationsSource
#1Emily Rose (NIH: National Institutes of Health)H-Index: 1
#2Marcela A. Ferrada (NIH: National Institutes of Health)H-Index: 5
Last. Peter C. Grayson (NIH: National Institutes of Health)H-Index: 25
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OBJECTIVE Relapsing polychondritis (RP) is a systemic inflammatory disorder of cartilage that lacks validated disease activity measures. Physician global assessment (PhGA), a measure of disease activity commonly used in rheumatologic diseases, has not been tested in a cohort of patients with RP. METHODS Adult patients in an observational cohort of RP underwent standardized, comprehensive evaluation at approximately 6-month intervals. PhGA was scored by three physicians from the evaluating instit...
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#1Shubhasree Banerjee (UPenn: University of Pennsylvania)H-Index: 6
#2Michael D. George (UPenn: University of Pennsylvania)H-Index: 15
Last. Peter C. Grayson (NIH: National Institutes of Health)H-Index: 25
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Objective This study aimed to analyze the concerns and health-related behaviors in patients with vasculitis during the early phase of the coronavirus disease 2019 (COVID-19) pandemic in North America. Methods Patients with vasculitis in North America were invited to complete an online survey through the Vasculitis Patient-Powered Research Network in collaboration with the Vasculitis Foundation and the Relapsing Polychondritis Foundation. Questions focused on concerns and behaviors related to doc...
2 CitationsSource
1 CitationsSource
#1David D'Cruz (Guy's Hospital)H-Index: 61
#2Marcela A. Ferrada (NIH: National Institutes of Health)H-Index: 5
Relapsing polychondritis (RP) is a rare and in some cases fatal systemic inflammatory rheumatic disorder characterized by episodic inflammation of cartilage1,2,3. Common clinical features include chondritis of the nasal bridge, auricular cartilage, ocular and inner ear inflammation, arthritis, and involvement of the tracheobronchial tree. Destruction of the laryngeal and tracheal cartilage rings may lead to collapse of the airways and is associated with a high risk of morbidity and mortality4. I...
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#1David B. BeckH-Index: 14
#2Zhijie Wu (NIH: National Institutes of Health)H-Index: 6
Last. Peter C. GraysonH-Index: 25
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#2David B. BeckH-Index: 14
Last. Katherine R. Calvo (NIH: National Institutes of Health)H-Index: 49
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3 CitationsSource
#1David B. BeckH-Index: 14
#2Marcela A. Ferrada (NIH: National Institutes of Health)H-Index: 5
Last. Peter C. GraysonH-Index: 25
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Abstract Background Adult-onset inflammatory syndromes often manifest with overlapping clinical features. Variants in ubiquitin-related genes, previously implicated in autoinflammatory disease, may...
22 CitationsSource
Last. D Kastner
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