Mark Emberton
University College London
CancerInternal medicineRadiologyUrologySurgeryMagnetic resonance imagingOncologyBiopsyProstateHigh-intensity focused ultrasoundDiseaseProstatectomyLower urinary tract symptomsProstate cancerProstate biopsyProstate-specific antigenGynecologyFocal therapyMedicine
Publications 818
#2Derek J. Lomas (Mayo Clinic)H-Index: 4
Last. Mieke Van Hemelrijck ('KCL': King's College London)H-Index: 36
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INTRODUCTION: The primary objective of the ReIMAGINE Prostate Cancer Screening Study is to explore the uptake of an invitation to prostate cancer screening using MRI. METHODS AND ANALYSIS: The ReIMAGINE Prostate Cancer Screening Study is a prospective single-centre feasibility study. Eligible men aged 50-75 years with no prior prostate cancer diagnosis or treatment will be identified through general practitioner practices and randomly selected for invitation. Those invited will be offered an MRI...
#1Gaelle FiardH-Index: 12
#2Aminah Chowdhury (Guy's and St Thomas' NHS Foundation Trust)
Last. Tet Yap (Guy's and St Thomas' NHS Foundation Trust)
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Abstract null null Context null Focal therapy has emerged as a promising option to treat well-selected men with localised prostate cancer while preserving healthy prostate tissue and key structures, such as the urethral sphincter and neurovascular bundles. However, how this tissue preservation may translate into improved outcomes, particularly into improved sexual outcomes, is still an active research field. null null null Objective null We conducted a systematic review and meta-analysis of the ...
#1Celeste Manfredi (Seconda Università degli Studi di Napoli)H-Index: 4
#2Esaú Fernández-Pascual (Universidad Francisco de Vitoria)H-Index: 6
Last. Felipe CouñagoH-Index: 8
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Abstract null null Context null Prostate-specific membrane antigen (PSMA) positron emission tomography/magnetic resonance imaging (PET/MRI) is a novel imaging technique with several potential applications in the prostate cancer (PCa) setting. null null null Objective null To perform a systematic review of the current evidence regarding the diagnostic performance of PSMA PET/MRI in patients with primary and recurrent PCa. null null null Evidence acquisition null A comprehensive bibliographic sear...
#1Alexander P. ColeH-Index: 16
#2Xi ChenH-Index: 1
Last. Nancy L. KeatingH-Index: 77
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#1Gaelle FiardH-Index: 12
Last. Tet YapH-Index: 10
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#1Maria ApfelbeckH-Index: 9
#2Alexander BuchnerH-Index: 31
Last. Mark EmbertonH-Index: 80
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#1Joseph M. Norris (UCL: University College London)H-Index: 10
#2Lucy A.M. Simmons (UCL: University College London)H-Index: 9
Last. Hashim U. Ahmed (Imperial College London)H-Index: 62
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Abstract null null Background null Multiparametric magnetic resonance imaging (mpMRI) has improved risk stratification for suspected prostate cancer in patients following prior biopsy. However, not all significant cancers are detected by mpMRI. The PICTURE study provides the ideal opportunity to investigate cancer undetected by mpMRI owing to the use of 5 mm transperineal template mapping (TTPM) biopsy. null null null Objective null To summarise attributes of cancers systematically undetected by...
#1Francesco Giganti (UCL: University College London)H-Index: 24
#2Eoin Dinneen (UCL: University College London)H-Index: 4
Last. Caroline M. Moore (UCL: University College London)H-Index: 34
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The Prostate Imaging Quality (PI-QUAL) score assesses the quality of multiparametric MRI (mpMRI). A score of 1 means all sequences are below the minimum standard of diagnostic quality, 3 implies that the scan is of sufficient diagnostic quality, and 5 means that all three sequences are of optimal diagnostic quality. We investigated the inter-reader reproducibility of the PI-QUAL score in patients enrolled in the NeuroSAFE PROOF trial. We analysed the scans of 103 patients on different MR systems...
#1Gaelle FiardH-Index: 12
#2Vasilis Stavrinides (UCL: University College London)H-Index: 7
Last. Mark Emberton (UCL: University College London)H-Index: 80
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Senescent cells accumulate with age in all tissues. Although senescent cells undergo cell-cycle arrest, these cells remain metabolically active and their secretome - known as the senescence-associated secretory phenotype - is responsible for a systemic pro-inflammatory state, which contributes to an inflammatory microenvironment. Senescent cells can be found in the ageing prostate and the senescence-associated secretory phenotype and can be linked to BPH and prostate cancer. Indeed, a number of ...