Tooru Shimosegawa
Tohoku University
CancerInternal medicineEndocrinologySurgeryPathologyHepatic stellate cellChemistryImmunologyPancreatitisHelicobacter pyloriAcute pancreatitisAutoimmune pancreatitisPancreasPancreatic cancerHepatologyCancer researchMedicineBiologyGastroenterologyCell biology
935Publications
95H-index
22kCitations
Publications 930
Newest
#1Kazuaki Norita (Tohoku University)H-Index: 1
#2Kiyotaka Asanuma (Tohoku University)H-Index: 13
Last. Atsushi Masamune (Tohoku University)H-Index: 67
view all 15 authors...
Background and objective Weakly acidic reflux reaching to the proximal esophagus is closely related to the perception of gastroesophageal reflux in patients with nonerosive reflux disease despite treatment with a proton pump inhibitor (PPI). However, little is known about the involvement of the patients' mucosal integrity of the proximal esophagus. Methods We recruited 15 symptomatic nonerosive gastroesophageal reflux disease (GERD) patients with a positive symptom index despite PPI treatment an...
1 CitationsSource
#1Hiroshi Nagai (Tohoku University)H-Index: 34
#2Masatake Kuroha (Tohoku University)H-Index: 12
Last. Atsushi Masamune (Tohoku University)H-Index: 67
view all 15 authors...
INTRODUCTION Exosomes are membrane-enclosed nanovesicles, which are increasingly being recognized as important cell communication components for their role in transmitting microRNAs (miRNAs). No previous study has addressed the exosomal miRNA profile in colorectal adenomas (CRAs) because the long-term culture of CRA is challenging. This study aimed to identify the miRNA signature in organoid exosomes derived from human CRA and colorectal cancer (CRC) samples. METHODS Organoid cultures were devel...
1 CitationsSource
#1Yasuhiro Takikawa (Iwate Medical University)H-Index: 26
#2Keisuke Kakisaka (Iwate Medical University)H-Index: 11
Last. Tooru ShimosegawaH-Index: 95
view all 8 authors...
AIM Acute liver failure (ALF) patients with coma need to be revived not only for spontaneous recovery but also as a bridge to liver transplantation. We developed a new high-volume plasma purification system using an on-line continuous hemodiafiltration (CHDF) system, and evaluated its safety and efficacy in a multicenter study. METHODS A single arm interventional study using the new apparatus was undertaken in the six major liver centers in Japan. The primary end-point was the proportion of pati...
3 CitationsSource
#1Fumiko ShimodaH-Index: 1
#2Akihiko SatohH-Index: 29
Last. Tooru ShimosegawaH-Index: 95
view all 5 authors...
Situs inversus totalis (SIT) is a rare congenital anomaly in which all viscera are transposed to the opposite side of the body. This uncommon anatomy causes technical difficulties in endoscopic treatment. A 98-year-old woman with SIT was admitted to our hospital complaining of upper abdominal pain and fever. Blood examinations and findings of abdominal computed tomography imaging confirmed the diagnosis of acute pancreatitis and cholangitis associated with biliary stones. After recovering from p...
1 CitationsSource
#1Kazuaki Norita (Tohoku University)H-Index: 1
#2Tomoyuki Koike (Tohoku University)H-Index: 26
Last. Katsunori Iijima (Akita University)H-Index: 25
view all 22 authors...
Objects Although a recent study showed the cancer incidence of Barrett's esophagus (BE) to be 1.2%/year in 251 patient-years in Japan, the long-term outcomes remain unclear. The present study estimated the cancer risk of BE in Japan using our original prospective multicenter cohort. Methods A total of 98 patients with BE of maximum length of ≥2 cm were enrolled during the period of 2010 to 2012 and received at least 1 follow-up endoscopy over 5 years thereafter. Cancer incidence rates with 95% c...
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#1Masatake Kuroha (Tohoku University)H-Index: 12
#2Hisashi Shiga (Tohoku University)H-Index: 3
Last. Atsushi Masamune (Tohoku University)H-Index: 67
view all 15 authors...
BACKGROUND Submucosal fibrosis observed during colorectal endoscopic submucosal dissection (ESD) is an important factor related to incomplete resection. Biopsy is generally accepted as having the potential to elicit submucosal fibrosis, but few reports have presented definitive proof. This study investigated the relation between submucosal fibrosis and colorectal ESD outcomes and assessed factors related to fibrosis, including pretreatment biopsy. METHODS After reviewing 369 records of colorecta...
1 CitationsSource
#2Osamu KimuraH-Index: 16
Last. Tooru ShimosegawaH-Index: 95
view all 10 authors...
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#2Kazuhiro Kikuta (Tohoku University)H-Index: 32
#3Kiyoshi Kume (Tohoku University)H-Index: 22
Last. Kazuichi Okazaki (Kansai Medical University)H-Index: 85
view all 8 authors...
OBJECTIVES To provide updated clinico-epidemiological information on chronic pancreatitis (CP) in Japan. METHODS We conducted a two-stage nationwide epidemiological survey; the number of CP patients was estimated in the first-stage survey, and their clinical features were examined in the second-stage survey. We surveyed patients with CP who had visited hospitals in 2016 and were diagnosed according to the Japanese diagnostic criteria 2009 (DC2009). Furthermore, we validated the new Japanese diag...
3 CitationsSource
#1William Greenhalf (University of Liverpool)H-Index: 50
#2Philippe Lévy (University of Paris)H-Index: 14
Last. John P. Neoptolemos (Heidelberg University)H-Index: 125
view all 26 authors...
Abstract Background Patients with chronic pancreatitis (CP) have an increased risk of pancreatic cancer. We present the international consensus guidelines for surveillance of pancreatic cancer in CP. Methods The international group evaluated 10 statements generated from evidence on 5 questions relating to pancreatic cancer in CP. The GRADE approach was used to evaluate the level of evidence available per statement. The working group voted on each statement for strength of agreement, using a nine...
12 CitationsSource
#1C. Mel Wilcox (UAB: University of Alabama at Birmingham)H-Index: 64
#2Thomas M. Gress (University of Marburg)H-Index: 82
Last. John P. Neoptolemos (Heidelberg University)H-Index: 125
view all 16 authors...
Abstract Background Chronic pancreatitis (CP) is a complex inflammatory disease with variable presentations and outcomes. This statement is part of the international consensus guidelines on CP, specifically on the diagnostic role of endoscopic ultrasound (EUS). Methods An international working group with experts on the role of diagnostic EUS in the management of CP from the major pancreas societies (IAP, APA, JPS, and EPC) evaluated two key statements generated from evidence on two questions dee...
1 CitationsSource