Xinglan An
Jilin University
Internal medicinemicroRNAMolecular biologyDNA demethylationGene knockdownChemistryDNA methylationEmbryoGenomic imprintingSomatic cell nuclear transferHomeobox protein NANOGSOX2BlastocystMethylationEpigeneticsCancer researchReprogrammingCell cultureBiologyEmbryogenesisCell biology
29Publications
10H-index
212Citations
Publications 29
Newest
#1Yanhui Zhai (JLU: Jilin University)H-Index: 5
#2Meng Zhang (JLU: Jilin University)H-Index: 9
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 9 authors...
Pre-implantation embryos undergo genome-wide DNA demethylation, however certain regions, like imprinted loci remain methylated. However, the mechanisms ensuring demethylation resistance by TRIM28 in epigenetic reprogramming remain poorly understood. Here, TRIM28 was knocked down in oocytes, and its effects on porcine somatic cell nuclear transfer (SCNT) embryo development was examined. Our results showed that SCNT embryos constructed from Trim28 knockdown oocytes had significantly lower cleavage...
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#1Daoyu Zhang (JLU: Jilin University)H-Index: 1
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 4 authors...
Breast cancer is one of the most prevalent and reoccurring cancer types that leads to death in women. Triple-negative breast cancer (TNBC) is difficult to treat due to the lack of therapeutic targets. Many studies have focused on identifying drugs for use as alternative treatments for breast cancer. Thioguanine (6-TG) exerts antitumor effects in cancer. Increasing evidence has demonstrated that ceRNAs are involved in cancer processes. However, the mechanism by which 6-TG regulates lncRNA-miRNA-m...
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#1Hao Li (JLU: Jilin University)H-Index: 1
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 5 authors...
Previous research has proven that 6-thioguanine (6-TG) inhibits the growth of MCF-7 breast cancer cells. Accumulating evidence indicates that long non-coding (lnc)RNAs are involved in the development of various cancer types as competitive endogenous (ce)RNA molecules. The present study was conducted to investigate the regulatory mechanism underlying the function of lncRNAs as ceRNA molecules in MCF-7 cells and to identify more effective prognostic biomarkers for breast cancer treatment. The expr...
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#1Meng ZhangH-Index: 9
#2Sheng ZhangH-Index: 9
Last. Ziyi LiH-Index: 14
view all 8 authors...
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#1Daoyu Zhang (JLU: Jilin University)H-Index: 1
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 10 authors...
Triple-negative breast cancer (TNBC) is notoriously difficult to treat due to the lack of biological targets and poor sensitivity to conventional therapies. Chemotherapy is the main clinical therapy, but the effective screening strategy for chemotherapy drugs is poorly investigated. Drug repositioning has been the center of attention in recent years attracting numerous studies. Here, we firstly found multiple common features between leukemia and TNBC by analyzing the global transcriptome profile...
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#1Jian Zhang (JLU: Jilin University)H-Index: 165
#2Linlin Hao (JLU: Jilin University)H-Index: 1
Last. Bo Tang (JLU: Jilin University)H-Index: 13
view all 11 authors...
Somatic cell nuclear transfer (SCNT) has been successfully used for cloning in a variety of mammalian species. However, SCNT reprogramming efficiency is relatively low, in part due to incomplete DNA methylation reprogramming of donor cell nuclei. We previously showed that ten-eleven translocation 3 (TET3) is responsible for active DNA demethylation during preimplantation embryonic development in bovines. In this study, we constructed TET3-overexpressing cell lines in vitro and observed that the ...
1 CitationsSource
#1Meng Zhang (JLU: Jilin University)H-Index: 9
#2Han Y (JLU: Jilin University)H-Index: 1
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 7 authors...
Tissue-specific fat deposition is regulated by a series of complex regulatory mechanisms. Reports indicate that epigenetic regulators, such as circular RNAs (circRNAs), are crucial in diseases progression, animal development, metabolism, and adipogenesis. In this study, to assess the functional roles of circRNAs in adipogenesis and tissue-specific fat deposition, we comprehensively analyzed the Ribo-Zero RNA-Seq and miRNAs data during chicken intramuscular and abdominal adipogenic differentiatio...
3 CitationsSource
#1Yu Jiang (JLU: Jilin University)H-Index: 3
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Xueming Zhang (JLU: Jilin University)H-Index: 9
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Abstract Although induced pluripotent stem cells (iPSCs) had been generated from several somatic cell types in cattle, their pluripotency and differentiation capacities after freezing/thawing, and the dysregulated transcripts involved in pathways critical for reprogramming were not investigated. Additionally, selection of proper source cells is critical for iPSC derivation because the residual influence of the somatic origin may variegate their differentiation propensity. Sertoli cells (SCs) hav...
2 CitationsSource
#1Qi Li (JLU: Jilin University)H-Index: 3
#2Yanhui Zhai (JLU: Jilin University)H-Index: 5
Last. Xinglan An (JLU: Jilin University)H-Index: 10
view all 5 authors...
Mesenchymal stem/stromal cells (MSCs) have been identified in almost all adult human tissues and been used in numerous clinical trials for a variety of diseases. Studies have shown that MSCs would ...
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#1Hao Li (JLU: Jilin University)H-Index: 1
#2Xinglan An (JLU: Jilin University)H-Index: 10
Last. Ziyi Li (JLU: Jilin University)H-Index: 14
view all 7 authors...
Background: 6-thioguanine (6-TG), as a conventional "ancient" drug for the treatment of acute leukemia, has been proved to have extensive anti-tumor roles. This study was created to investigate the hidden function of 6-TG on the MCF-7 breast cancer cell line (ER+, PR+) and its mechanisms. Methods: MCF-7 cells were treated with 6-TG, and the IC50 value was measured by a cell counting kit-8 assay. Differentially expressed genes (DEGs) were confirmed by RNA-seq analysis. Apoptosis and cell cycle co...
2 CitationsSource