Mehdi Razzaghi-Abyaneh
Pasteur Institute of Iran
MyceliumCorpus albicansBiotechnologyChemistryAspergillus parasiticusDermatophyteAspergillus flavusErgosterolAspergillusCandida albicansAntifungal drugFood scienceAflatoxinVeterinary medicineBiochemistryBotanyMedicineMycotoxinBiologyMicrobiology
Publications 133
#1Sima Sadat Seyedjavadi (Pasteur Institute of Iran)H-Index: 10
#2Soghra Khani (Pasteur Institute of Iran)H-Index: 10
Last. Mehdi Razzaghi-Abyaneh (Pasteur Institute of Iran)H-Index: 24
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Due to increasing the rate of invasive fungal infections and emerging antifungal resistance, development of novel antifungal drugs has been an urgent necessity. Antifungal peptides (AFPs) have recently attracted attention due to their unique ability to evade the drug resistant fungal pathogens. In this study, a novel AFP, Cc-AFP1, with a molecular weight of ~ 3.759 kDa, was isolated from Carum carvi L., purified by ammonium sulfate precipitation and reverse phase HPLC and finally identified by s...
#1Esmat Mirbzadeh Ardakani (Pasteur Institute of Iran)
#2Atefeh Sharifirad (Pasteur Institute of Iran)H-Index: 2
Last. Vahid Khalaj (Pasteur Institute of Iran)H-Index: 13
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Superficial fungal infections are prevalent worldwide, with dermatophytes, as the most common cause. Various antifungal agents including azoles and allylamines are commonly used to treat dermatophytosis. However, their overuse has yielded drug-resistant strains, calling for the development of novel anti-mycotic compounds. Olorofim, is a newly developed antifungal compound, which targets pyrimidine biosynthesis in molds. The purpose of this study was to determine the in vitro and in vivo antifung...
#1Soghra Khani (Pasteur Institute of Iran)H-Index: 10
#2Sima Sadat Seyedjavadi (Pasteur Institute of Iran)H-Index: 10
Last. Mehdi Razzaghi-AbyanehH-Index: 24
view all 11 authors...
DiSkh-AMP1, a novel dimeric antifungal peptide contained 65 amino acid residues was recombinant produced by a flexible linker to improve the antifungal activity of native Skh-AMP1 isolated from Satureja khuzistanica leaves. To discover a new system for expressing DiSkh-AMP1 in Escherichia coli BL21, the DiSkh-AMP1 gene was synthesized and inserted into pET28a vector in which fusion peptide (3.5 kDa) was used as a fusion partner and an N-terminal 6-His as an affinity tag. The fusion/DiSkh-AMP1 pe...
#2Soghra KhaniH-Index: 10
#4Hadi Zare-ZardiniH-Index: 12
Background- Dermatophytes are a homogeneous group of species with low genetic diversity and there are still many uncertainties about the boundaries among species. Objectives- Aiming at clarifying the relationships among species in the genus and introducing suitable genes for multilocus sequence typing (MLST), a new MLST scheme approach was developed to characterize the major pathogenic dermatophytes. Methods- We performed maximum parsimony, MrBayes, RAxML, and eBURST analyses, based on the MLST ...
#1Atefeh Tavangar (IUMS: Isfahan University of Medical Sciences)H-Index: 3
#2Faezeh Khozeimeh (IUMS: Isfahan University of Medical Sciences)H-Index: 7
Last. Safieh Sherkat (Shahrekord University of Medical Sciences)
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Statement of the Problem: Various species of candida contribute to oral candidiasis. It is the time to shift therapies from conventional rigid antimicrobial therapies to more patient specific and safer ones. Purpose: The present study aimed to investigate antifungal effects of photodynamic therapy (PDT) using Indocyanine green as photosensitizer and low-power laser irradiation on the viability of candida albicans, candida tropicalis, candida glabrata and candida krusei, and to compare it with Ny...
#1Mostafa Teymuri (TMU: Tarbiat Modares University)H-Index: 7
#2Masoomeh Shams-Ghahfarokhi (TMU: Tarbiat Modares University)H-Index: 23
Last. Mehdi Razzaghi-Abyaneh (Pasteur Institute of Iran)H-Index: 24
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Cryptococcosis is an opportunistic fungal infection caused mainly by Cryptococcus neoformans. The aim of the present study was to evaluate the inhibitory effect of aureobasidin A on C. neoformans with special focus on its mode of action. The effect of aureobasidin A on cell membrane ergosterol content, cell wall permeability, membrane pumps activities, the total oxidant status (TOS) and melanin production was evaluated. Cytotoxicity and cell hemolysis, and laccase (LacI) and β1,2-xylosyltransfer...
1 CitationsSource
#1Fatemeh Ebrahimi-Shaghaghi (IAU: Islamic Azad University)
#2Zahra Noormohammadi (IAU: Islamic Azad University)H-Index: 15
Last. Mehdi Razzaghi-Abyaneh (Pasteur Institute of Iran)H-Index: 24
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Abstract In spite of the abundance of antifungal therapies, 75% of women in the world suffer from the second most common cause of vaginal infection named vulvovaginal candidiasis. This complication is characterized with overgrowth of Candida albicans. The low efficacy and side effects of current antifungal therapies have convinced the researchers to look for a non-antibiotic based treatment such as cold atmospheric plasmas (CAP). The aim of this research was to evaluate the effects of CAP on C. ...
1 CitationsSource