Jian-Guang Luo
China Pharmaceutical University
CytotoxicityCircular dichroismCytotoxic T cellOrganic chemistryHigh-performance liquid chromatographyChemistryApoptosisGlycosideTwo-dimensional nuclear magnetic resonance spectroscopyTerpenoidAbsolute configurationIC50Ic50 valuesChromatographyTerpeneNitric oxideBiochemistryTraditional medicineCountercurrent chromatographyStereochemistryBiology
252Publications
28H-index
3,104Citations
Publications 236
Newest
#1Chen Chen (CPU: China Pharmaceutical University)H-Index: 6
#2Li-Jie Gong (CPU: China Pharmaceutical University)
Last. Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 28
view all 7 authors...
Abstract null null Peroxiredoxin 6 (PRDX6), as a bifunctional enzyme with glutathione peroxidase activity (GPx) and Ca2+-independent phospholipase A2 (iPLA2) activity, has a higher expression in various cancer cells, which leads to the increase of antioxidant properties and promotes tumorigenesis. However, only a few inhibitors of PRDX6 have been discovered to date, especially the covalent inhibitors of PRDX6. Here, we firstly identified Withangulatin A (WA), a natural small molecule, as a novel...
Source
#1Xiaoyun Zhu (CPU: China Pharmaceutical University)H-Index: 3
#2Shengtao Ye (CPU: China Pharmaceutical University)H-Index: 1
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
view all 12 authors...
Background and purpose Liver fibrosis is one of the leading causes of morbidity and mortality worldwide of which no acceptable therapy exists. Accumulating evidence supports that glioma-associated oncogene homologue 1 (GLI1) is a potentially important therapeutic target for liver fibrosis. This study investigates the antifibrotic activities and potential mechanisms of Physalin B (PB), a natural Solanaceae compound. Experimental approach Mice subjected to carbon tetrachloride (CCl4 ) challenge an...
2 CitationsSource
#1Li Zhu (CPU: China Pharmaceutical University)H-Index: 1
#2Li-Jie Gong (CPU: China Pharmaceutical University)
Last. Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 28
view all 7 authors...
Six new Cephalotaxus alkaloids, including five cephalotaxine-type alkaloids, and one homoerythrina-type alkaloid, along with six known analogues, were isolated from the seeds of Cephalotaxus fortunei. Their structures were elucidated by combination of spectroscopic data analyses, time-dependent density functional theory (TDDFT) ECD calculation, and single-crystal X-ray diffraction. Cephalofortine B represents the first example of C-5 epi-cephalotaxine-type alkaloid. All isolated compounds were t...
Source
#1Van-Tuan Vu (CPU: China Pharmaceutical University)
#2Xiao-Juan Xu (CPU: China Pharmaceutical University)
Last. Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 28
view all 8 authors...
Six new oligomeric neolignans including two trimeric neolignans (1 and 2) and four dimeric neolignans (3-6) were isolated from the leaves of Magnolia officinalis var. biloba. Their structures were determined based on HR-ESIMS and NMR data, as well as electronic circular dichroism (ECD) calculations. Compound 1 is formed from two obovatol moieties directly linked to an aromatic ring of the remaining obovatol moiety, which is an unprecedented type of linkage between monomers. All isolates were ass...
Source
#1Chen Chen (CPU: China Pharmaceutical University)H-Index: 6
#2Tianyu Zhu (CPU: China Pharmaceutical University)H-Index: 5
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
view all 10 authors...
Abstract null null The first rate-limiting enzyme of the serine synthesis pathway (SSP), phosphoglycerate dehydrogenase (PHGDH), is hyperactive in multiple tumors, which leads to the activation of SSP and promotes tumorigenesis. However, only a few inhibitors of PHGDH have been discovered to date, especially the covalent inhibitors of PHGDH. Here, we identified withangulatin A (WA), a natural small molecule, as a novel covalent inhibitor of PHGDH. Affinity-based protein profiling identified that...
Source
#1Dong-Rong Zhu (CPU: China Pharmaceutical University)H-Index: 5
#2Chen Chen (CPU: China Pharmaceutical University)H-Index: 6
Last. Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 28
view all 8 authors...
Abstract null null Introduction null Previously, we have reported a withanolide-type steroid, named tubocapsenolide A (TA), which shows potent anti-proliferative activity in several cancer cell lines. However, its inhibitory effect on the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway and therapeutic potential on osteosarcoma have not been reported. null null null Objectives null In the present study, we aimed to investigate the effect and molecular mechanism...
Source
#1Chen Chen (CPU: China Pharmaceutical University)H-Index: 6
#2Xiao-Qin Liu (CPU: China Pharmaceutical University)H-Index: 2
Last. Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 28
view all 7 authors...
Abstract null null Increasing evidence have reported that NLRP3 inflammasome has a crucial role in various kinds of immunological diseases including colitis. However, there have only a few drug candidates directly targeting inflammasomes for the therapy of colitis. Here, we first reported that Tubocapsanolide A (TA), a natural small molecule, as a novel inhibitor of NLRP3 inflammasome for the treatment of colitis. TA inhibited the activation of NLRP3 inflammasome and suppressed the secretion of ...
Source
#1Hua-Rong Zhao (CPU: China Pharmaceutical University)
#2Xiao-Qin Liu (CPU: China Pharmaceutical University)H-Index: 2
Last. Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 28
view all 5 authors...
Abstract Four new highly oxidized sesquiterpene lactones, Argyoxynolides A–D, along with two known analogs were isolated from the leaves of Artemisia argyi H.Lev. & Vaniot. Their structures were characterized utilizing extensive spectroscopic methods. All isolates were evaluated for the LPS-induced nitric oxide (NO) production inhibitory activity and one compound exhibited activity with IC50 = 37.95 ± 4.39 μM.
Source
#1Li Zhu (CPU: China Pharmaceutical University)H-Index: 1
#2Dong-Rong Zhu (CPU: China Pharmaceutical University)H-Index: 5
Last. Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 28
view all 8 authors...
Fortuneicyclidins A (1) and B (2), a pair of epimeric pyrrolizidine alkaloids containing an unprecedented 7-azatetracyclo[5.4.3.0.02,8]tridecane core, were isolated from the seeds of Cephalotaxus fortunei, along with two biogenetically relative known analogues, 3 and 4. The structures were determined by multiple spectral techniques and chemical derivatization methods. Compound 1 showed inhibitory activity against α-glucosidase.
1 CitationsSource
#1Wen-Li Wang (CPU: China Pharmaceutical University)H-Index: 6
#2Xiao-Qin Liu (CPU: China Pharmaceutical University)H-Index: 2
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
view all 9 authors...
Abstract Taxodinoid A (1), an unprecedented bis-diterpenic anhydride featuring a 6/6/7/6/6/6 heptacyclic core skeletons, and three novel pyrane-fused abietane-type diterpene dimers (2-4), were obtained from the seeds of Taxodium distichum. Their structures were elucidated by spectroscopic data, X-ray crystallograph and electronic circular dichroism calculation. A biosynthetic pathway and suppressing migration activity against U2 OS cells were also discussed.
Source