Ole A. Andreassen
Oslo University Hospital
Genome-wide association studyPsychiatryInternal medicineEndocrinologySingle-nucleotide polymorphismPsychologyNeuroscienceCognitionGenetic associationBipolar disorderDiseasePsychosisPopulationGeneticsNeuroimagingClinical psychologyMedicineSchizophreniaBiologyGenetic architecture
Publications 1130
#1Mary S Mufford (UCT: University of Cape Town)H-Index: 6
#2van der Meer D (University of Oslo)
Last. Dan J. Stein (UCT: University of Cape Town)H-Index: 163
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Background: Whereas a number of genetic variants influencing total amygdala volume have been identified in previous research, genetic architecture of its distinct nuclei have yet to be thoroughly explored. We aimed to investigate whether increased phenotypic specificity through segmentation of the nuclei aids genetic discoverability and sheds light on the extent of shared genetic architecture and biological pathways between the nuclei and disorders associated with the amygdala. Methods: T1-weigh...
#1Loechen Ar (University of Oslo)
#2K. K. Kolskaar (University of Oslo)H-Index: 4
Last. Lars T. Westlye (University of Oslo)H-Index: 74
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ObjectiveLow-level sensory disruption is hypothesized as a precursor to clinical and cognitive symptoms in severe mental disorders. We compared visual discrimination performance in patients with schizophrenia spectrum disorder or bipolar disorder with healthy controls, and investigated associations with clinical symptoms and IQ. null MethodsPatients with schizophrenia spectrum disorder (n=32), bipolar disorder (n=55) and healthy controls (n=152) completed a computerized visual discrimination tas...
#1Chun Chieh Fan (UCSD: University of California, San Diego)H-Index: 26
#2R. J. Loughnan (UCSD: University of California, San Diego)H-Index: 4
Last. Anders M. Dale (UCSD: University of California, San Diego)H-Index: 166
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It is important to understand the molecular determinants for microstructures of human brain. However, past genome-wide association studies (GWAS) on microstructures of human brain have had limited results due to methodological constraints. Here, we adopt advanced imaging processing methods and multivariate GWAS on two large scale imaging genetic datasets (UK Biobank and Adolescent Brain Cognitive Development study) to identify and validate key genetic association signals. We discovered 503 uniqu...
#1Weiqiu Cheng (Oslo University Hospital)H-Index: 1
#2Oleksandr Frei (Oslo University Hospital)H-Index: 19
Last. Guy Hindley ('KCL': King's College London)H-Index: 4
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Importance null Schizophrenia is a complex heritable disorder associated with many genetic variants, each with a small effect. While cortical differences between patients with schizophrenia and healthy controls are consistently reported, the underlying molecular mechanisms remain elusive. null Objective null To investigate the extent of shared genetic architecture between schizophrenia and brain cortical surface area (SA) and thickness (TH) and to identify shared genomic loci. null Design, setti...
#1Jennifer A. Sumner (UCLA: University of California, Los Angeles)H-Index: 27
#2Adam X. Maihofer (UCSD: University of California, San Diego)H-Index: 22
Last. Bekh Bradley (Emory University)H-Index: 66
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Growing research suggests that posttraumatic stress disorder (PTSD) may be a risk factor for poor cardiovascular health, and yet our understanding of who might be at greatest risk of adverse cardiovascular outcomes after trauma is limited. In this study, we conducted the first examination of the individual and synergistic contributions of PTSD symptoms and blood pressure genetics to continuous blood pressure levels. We harnessed the power of the Psychiatric Genomics Consortium-PTSD Physical Heal...
#1Daniël Roelfs (Oslo University Hospital)H-Index: 3
#2van der Meer D (UM: Maastricht University)
Last. Tobias Kaufmann (University of Tübingen)H-Index: 35
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Psychiatric disorders are complex, heritable, and highly polygenic. Supported by findings of abnormalities in functional magnetic resonance imaging (fMRI) based measures of brain connectivity, current theoretical and empirical accounts have conceptualized them as disorders of brain connectivity and dysfunctional integration of brain signaling, however, the extent to which these findings reflect common genetic factors remains unclear. Here, we performed a multivariate genome-wide association anal...
#1Linn B. Norbom (University of Oslo)H-Index: 11
#2Lia Ferschmann (University of Oslo)H-Index: 6
Last. Christian K. Tamnes (University of Oslo)H-Index: 42
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Abstract null null Through dynamic transactional processes between genetic and environmental factors, childhood and adolescence involve reorganization and optimization of the cerebral cortex. The cortex and its development plays a crucial role for prototypical human cognitive abilities. At the same time, many common mental disorders appear during these critical phases of neurodevelopment. Magnetic resonance imaging (MRI) can indirectly capture several multifaceted changes of cortical macro- and ...
1 CitationsSource
#1Monereo-Sánchez J (UM: Maastricht University)
#2Jurjen J. Luykx (UM: University of Michigan)H-Index: 22
Last. van der Meer D (University of Oslo)
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Background: COVID-19 is characterized by strikingly large, mostly unexplained, interindividual variation in symptom severity. While some individuals remain nearly asymptomatic, others suffer from severe respiratory failure. It has been hypothesized that previous vaccinations for other pathogens, in particular tetanus, may provide protection against severe COVID-19. Methods: We made use of data on COVID-19 testing from 103,049 participants of the UK Biobank (mean age 71.5 years, 54.2% female), co...
#1Mary Ann A. DeMichele-Sweet (University of Pittsburgh)H-Index: 11
#2Lambertus Klei (University of Pittsburgh)H-Index: 47
Last. Lluís Tárraga (International University Of Catalonia)H-Index: 25
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Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD with psychosis, AD + P). AD + P affects ~50% of individuals with AD, identifies a subgroup with poor outcomes, and is associated with a greater degree of cognitive impairment and depressive symptoms, compared to subjects without psychosis (AD - P). Although the estimated heritability of AD + P is 61%, genetic sources of risk are unknown. We report a genome-wide meta-analysis of 12,...
Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD...