Ariel Gore
Israel Institute for Biological Research
PathologyChemistryAtropineOrganophosphateCorneaInflammationMiosisCorneal neovascularizationNeovascularizationNerve agentMydriasisHomatropineSarinTropicamideSulfur mustardPupillary light reflexAnticholinergic agentsRabbit modelAnesthesiaMedicinePharmacology
22Publications
6H-index
112Citations
Publications 22
Newest
#1Ariel Gore (Israel Institute for Biological Research)H-Index: 6
#2Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
Last. Vered Horwitz (Israel Institute for Biological Research)H-Index: 10
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#1Vered Horwitz (Israel Institute for Biological Research)H-Index: 10
#2Inbal Egoz (Israel Institute for Biological Research)H-Index: 7
Last. Ariel Gore (Israel Institute for Biological Research)H-Index: 6
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#1Ariel GoreH-Index: 6
#2Adi Neufeld-CohenH-Index: 1
Last. Shlomi LazarH-Index: 11
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Abstract The development of refractory status epilepticus (SE) induced by sarin intoxication presents a therapeutic challenge. In our current research we evaluate the efficacy of a delayed combined triple treatment in ending the abnormal epileptiform seizure activity (ESA) and the ensuing of long-term neuronal insult. SE was induced in male Sprague-Dawley rats by exposure to 1.2LD50 sarin insufficiently treated by atropine and TMB4 (TA) 1 min later. Triple treatment of ketamine, midazolam and va...
1 CitationsSource
#1Ariel Gore (Israel Institute for Biological Research)H-Index: 6
#2Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
Last. Vered Horwitz (Israel Institute for Biological Research)H-Index: 10
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Abstract The use of sulfur mustard (SM) in global terrorism is still a relevant threat to both civilian population and military personnel. Casualties exposed to SM may present mild, moderate or severe acute ocular lesions followed by a complete ocular resolution, chronic lesions or re-emerged ocular pathologies after a latent period. Current treatment for SM-induced ocular injury is based mainly on the clinical manifestation at the different stages of the injury and includes pharmaceutical and s...
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#1Ariel Gore (Israel Institute for Biological Research)H-Index: 6
Warfare organophosphates (OP) nerve agents constitute one of the prime threats to mankind on the battlefield and in the scenario of civilian terror. Exposure to OP nerve agents dose-dependently result in incapacitation. They affect multiple organs, but the eye is one of the first and most frequently affected. Ocular OP insult may result in long-term miosis, impaired visual function and ocular pain thus inducing functional incapacitation. The currently recommended military medical doctrine of usi...
1 CitationsSource
#1Ariel Gore (Israel Institute for Biological Research)H-Index: 6
#2Adi Neufeld-Cohen (Israel Institute for Biological Research)H-Index: 1
Last. Shlomi Lazar (Israel Institute for Biological Research)H-Index: 11
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Abstract Background Sarin is an irreversible organophosphate cholinesterase inhibitor. Following toxic signs, an extensive long-term brain damage is often reported. Thus, we evaluated the efficacy of a novel anticonvulsant drug retigabine, a modulator of neuronal voltage gated K+ channels, as a neuroprotective agent following sarin exposure. Methods Rats were exposed to 1 LD50 or 1.2 LD50 sarin and treated at onset of convulsions with retigabine (5 mg/kg, i.p.) alone or in combination with 5 mg/...
6 CitationsSource
Last. Tamar KadarH-Index: 26
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Purpose: To further investigate the inflammatory response as one of the leading factors in the development of delayed limbal stem cell deficiency, clinically manifested by corneal neovascularization , following sulfur mustard ocular exposure in rabbits and to evaluate potential therapy. Materials and methods: Right eyes of rabbits were exposed to sulfur mustard vapor. Clinical examination was performed and the growth of corneal blood vessels was evaluated. Inflammatory cells (neutrophils, macrop...
Source
#1Ariel Gore (Israel Institute for Biological Research)H-Index: 6
#2Shlomi Lazar (Israel Institute for Biological Research)H-Index: 11
Last. Tamar Kadar (Israel Institute for Biological Research)H-Index: 26
view all 8 authors...
Abstract Eye exposure to organophosphate (OP) chemical warfare irreversible acetylcholinesterase inhibitors, results in long-term miosis and impaired visual function. In contrast to the well-documented miotic and ciliary muscle spasm observed following chemical warfare, OP ocular exposure, little is known regarding the ocular surface histopathological insult. The aim of the present study was to determine the degree of the ocular surface insult following sarin or VX ocular exposure and to evaluat...
3 CitationsSource
#1Vered Horwitz (Israel Institute for Biological Research)H-Index: 10
#2Inbar Cohen-Gihon (Israel Institute for Biological Research)H-Index: 5
Last. Ofir Israeli (Israel Institute for Biological Research)H-Index: 10
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Abstract Exposure to sulfur mustard (SM) may result in severe ocular injuries. While some of the eyes show a clinical resolution of the injury (defined as clinically non-impaired), part of the eyes develop irreversible late ocular pathologies (defined as clinically impaired) that may lead to corneal blindness. Understanding the pathological mechanisms underlying the development of the late pathology may lead to improved treatment options. Therefore, this study aimed to investigate the mRNA expre...
4 CitationsSource
#1Vered Horwitz (Israel Institute for Biological Research)H-Index: 10
#2Shlomit Dachir (Israel Institute for Biological Research)H-Index: 19
Last. Ariel Gore (Israel Institute for Biological Research)H-Index: 6
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Abstract Purpose The sight threatening sulfur mustard (SM) induced ocular injury presents specific symptoms for each clinical stage. The acute injury develops in all of the exposed eyes and is characterized by erosions and severe inflammation. The irreversible late pathology develops only in part of the eyes, and is clinically expressed by chronic inflammation and corneal neovascularization (NV). The mechanisms underlying this injury are still in research and treatment is insufficient. Aiming to...
12 CitationsSource