Matteo Moretti
University of Milan
AnatomyBiomedical engineeringPathologyCellBioreactorNanotechnologyChemistryMaterials scienceMesenchymal stem cellIn vitroIn vivoExtravasationCartilageChondrogenesisTissue engineeringCancer researchMedicineMicrofluidicsBiologyCell biologyCancer cell
Publications 145
#1Daniela Cruz-Moreira (Polytechnic University of Milan)H-Index: 5
#2Roberta Visone (Polytechnic University of Milan)H-Index: 8
Last. Marco Rasponi (Polytechnic University of Milan)H-Index: 19
view all 9 authors...
Heart-on-chip is an unprecedented technology for recapitulating key biochemical and biophysical cues in cardiac pathophysiology. Several designs have been proposed to improve its ability to mimic the native tissue and establish it as a reliable research platform. However, despite mimicking one of most vascularized organs, reliable strategies to deliver oxygen and substrates to densely packed constructs of metabolically demanding cells remain unsettled. Herein, we describe a new heart-on-chip pla...
#1Maria V. ColomboH-Index: 1
#2Simone BersiniH-Index: 17
Last. Matteo MorettiH-Index: 30
view all 9 authors...
Bone metastases occur in 65-80% advanced breast cancer patients. Although significant progresses have been made in understanding the biological mechanisms driving the bone metastatic cascade, traditional 2D in vitro models and animal studies are not effectively reproducing breast cancer cells (CCs) interactions with the bone microenvironment and suffer from species-specific differences, respectively. Moreover, simplified in vitro models cannot realistically estimate drug anti-tumoral properties ...
#1Luca Possenti (Polytechnic University of Milan)H-Index: 4
Last. Matteo MorettiH-Index: 30
view all 11 authors...
Ionizing radiation (IR) is used in radiotherapy as a treatment to destroy cancer. Such treatment also affects other tissues, resulting in the so-called normal tissue complications. Endothelial cells (ECs) composing the microvasculature have essential roles in the microenvironment’s homeostasis (ME). Thus, detrimental effects induced by irradiation on ECs can influence both the tumor and healthy tissue. In-vitro models can be advantageous to study these phenomena. In this systematic review, we an...
#1Marwa El Soury (UNITO: University of Turin)H-Index: 3
#2Óscar Darío García-García (UGR: University of Granada)H-Index: 4
Last. Víctor Carriel (UGR: University of Granada)H-Index: 23
view all 7 authors...
In critical nerve gap repair, decellularized nerve allografts are considered a promising tissue engineering strategy that can provide superior regeneration results compared to nerve conduits. Decellularized nerves offer a well-conserved extracellular matrix component that has proven to play an important role in supporting axonal guiding and peripheral nerve regeneration. Up to now, the known decellularized techniques are time and effort consuming. The present study, performed on rat sciatic nerv...
#2Chiara ArrigoniH-Index: 11
Last. Matteo MorettiH-Index: 30
view all 9 authors...
Cell seeding on 3D scaffolds is a very delicate step in tissue engineering applications, influencing the outcome of the subsequent culture phase, and determining the results of the entire experiment. Thus, it is crucial to maximize its efficiency. To this purpose, a detailed study of the influence of the geometry of the scaffold fibers on dynamic seeding efficiency is presented. 3D printing technology was used to realize PLA porous scaffolds, formed by fibers with a non-circular cross-sectional ...
#1Roberta Visone (Polytechnic University of Milan)H-Index: 8
#2Giovanni Stefano Ugolini (Polytechnic University of Milan)H-Index: 9
Last. Marco Rasponi (Polytechnic University of Milan)H-Index: 19
view all 10 authors...
Cardiac toxicity still represents a common adverse outcome causing drug attrition and post-marketing withdrawal. The development of relevant in vitro models resembling the human heart recently opened the path towards a more accurate detection of drug-induced human cardiac toxicity early in the drug development process. Organs-on-chip (OoC) have been proposed as promising tools to recapitulate in vitro the key aspects of the in vivo cardiac physiology and to provide a means to directly analyze fu...
#1Aruna Marchetto (LMU: Ludwig Maximilian University of Munich)H-Index: 7
#2Shunya Ohmura (LMU: Ludwig Maximilian University of Munich)H-Index: 7
Last. Thomas G. P. Grunewald (LMU: Ludwig Maximilian University of Munich)H-Index: 31
view all 25 authors...
Osteoarthritis frequently requires arthroplasty. Cementless implants are widely used in clinics to replace damaged cartilage or missing bone tissue. In cementless arthroplasty, the risk of aseptic loosening strictly depends on implant stability and bone-implant interface, which are fundamental to guarantee the long-term success of the implant. Ameliorating the features of prosthetic materials, including their porosity and/or geometry, and identifying osteoconductive and/or osteoinductive coating...
#1Dalila PettaH-Index: 7
#2Valentina BasoliH-Index: 11
Last. Tiziano SerraH-Index: 10
view all 14 authors...
Morphogenesis, a complex process, ubiquitous in developmental biology and many pathologies, is based on self-patterning of cells. Spatial patterns of cells, organoids, or inorganic particles can be forced on demand using acoustic surface standing waves, such as the Faraday waves. This technology allows tuning of parameters (sound frequency, amplitude, chamber shape) under contactless, fast and mild culture conditions, for morphologically relevant tissue generation. We call this method Sound Indu...
3 CitationsSource
#1Carlotta MondadoriH-Index: 2
#2Martina Crippa (Polytechnic University of Milan)H-Index: 1
Last. Chiara ArrigoniH-Index: 11
view all 6 authors...
Extravasation is a multi-step process implicated in many physiological and pathological events. This process is essential to get leukocytes to the site of injury or infection but is also one of the main steps in the metastatic cascade in which cancer cells leave the primary tumor and migrate to target sites through the vascular route. In this perspective, extravasation is a double-edged sword. This systematic review analyzes microfluidic 3D models that have been designed to investigate the extra...
3 CitationsSource