Devendra K. Agrawal
Western University of Health Sciences
Vitamin D and neurologyInternal medicineEndocrinologyPathologyCardiologyReceptorChemistryImmunologyAsthmaInflammationCytokineVascular smooth musclevitamin D deficiencyPathogenesisCancer researchBioinformaticsMedicineBiologyImmune systemCell biology
532Publications
63H-index
11.3kCitations
Publications 529
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#1Vikrant Rai (Western University of Health Sciences)H-Index: 16
#2Devendra K. Agrawal (Western University of Health Sciences)H-Index: 63
Inflammation is a major contributor to the development and progression of atherosclerosis. Interleukin (IL)-33 and IL-37, members of the IL-1 family, modulate inflammation, with IL-33 having a pro-inflammatory effect and IL-37 having anti-inflammatory properties. IL-37 is constitutively expressed at low levels but upregulated in inflammatory contexts. The aim of this study was to evaluate the effect of vitamin D on the expression of IL-33, IL-37, macrophages, and caspase-1 in the neointimal tiss...
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#1Finosh G. Thankam (Western University of Health Sciences)H-Index: 11
#2Connor G Diaz (Creighton University)H-Index: 2
Last. Devendra K. Agrawal (Western University of Health Sciences)H-Index: 63
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Replenishment of tenocytes to the injury site is an ideal strategy to improve healing response and accelerate the tendon ECM regeneration. The present study focused on the synthesis and characterization of a hybrid hydrogel scaffold system poly(propylene-fumarate)-alginate-polyvinyl alcohol-acrylic acid (PAPA) using poly(propylene-fumarate) (PPF), alginate, polyvinyl alcohol (PVA) and acrylic acid and the in vitro investigation of bidirectional mobility of swine shoulder tenocytes (SST) for its ...
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#1Devendra K. AgrawalH-Index: 63
#2Finosh G. ThankamH-Index: 11
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#1Devendra K. AgrawalH-Index: 63
#2Vikrant RaiH-Index: 16
Source
#1Devendra K. Agrawal (Western University of Health Sciences)H-Index: 63
#2Finosh G. Thankam (Western University of Health Sciences)H-Index: 11
1 CitationsSource
#1Rebecca Kuan (Western University of Health Sciences)
#2Devendra K. Agrawal (Western University of Health Sciences)H-Index: 63
Last. Finosh G. Thankam (Western University of Health Sciences)H-Index: 11
view all 3 authors...
Atherosclerosis involves both innate and adaptive immunity. Here, we provide an overview of the role of regulatory T (Treg) cells in atherosclerotic diseases. Treg cells and their inhibitory cytokines, IL-10 and TGF-β, have been identified in atherosclerotic lesions and to inhibit progression through lipoprotein metabolism modulation. Treg cells have also been found to convert to T follicular helper (Tfh) cells and promote atherosclerosis progression. Treg cell involvement in different stages of...
1 CitationsSource
#1Harbinder Singh (College of Osteopathic Medicine of the Pacific)H-Index: 10
#2Vikrant Rai (College of Osteopathic Medicine of the Pacific)H-Index: 16
Last. Devendra K. Agrawal (College of Osteopathic Medicine of the Pacific)H-Index: 63
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INTRODUCTION : Atherosclerosis is a chronic inflammatory disease in which the members of S100 family proteins (calgranulins) bind with their receptors, particularly receptor for advanced glycation end products (RAGE) and toll-like receptor-4 (TLR-4) and play a key role in the pathogenesis and progression of disease. Thus, these proteins could be considered as potential biomarkers and therapeutic targets in the treatment of atherosclerotic inflammation. AREAS COVERED : This review summarizes the ...
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#1Vikrant RaiH-Index: 16
Hepatocellular carcinoma (HCC), accounting for more than 90% of cases of primary liver cancer, is the third most common cause of cancer-related death worldwide. Chronic inflammation precedes the development of cirrhosis and HCC. TREM (triggering receptor expressed on myeloid cell)-1 is an inflammatory marker and amplifier of inflammation that signals through PI3K and ERK1/2 to activate transcription factors, resulting in increased secretion of pro-inflammatory cytokines, causing chronic inflamma...
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#1Jonathan Tam (Western University of Health Sciences)H-Index: 1
#2Finosh G. Thankam (Western University of Health Sciences)H-Index: 11
Last. Mohamed M. Radwan (Western University of Health Sciences)H-Index: 7
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Cardiovascular disease (CVD) is a major contributor to annual deaths globally. Atherosclerosis is a prominent risk factor for CVD. Although significant developments have been recently made in the prevention and treatment, the molecular pathology of atherosclerosis remains unknown. Interestingly, the recent discovery of proprotein convertase subtilisin/kexin type 9 (PCSK9) introduced a new avenue to explore the molecular pathogenesis and novel management strategies for atherosclerosis. Initial re...
1 CitationsSource