Franca Ferrari
University of Pavia
Penetration (firestop)Biomedical engineeringNuclear chemistryComposite materialChemistryMaterials scienceBuccal administrationRheologyIn vivoPlatelet lysateChitosanDrug deliveryMucoadhesionWound healingChemical engineeringChromatographyPolymerMedicineDosage formPharmacology
220Publications
38H-index
4,138Citations
Publications 154
Newest
#1Barbara ViganiH-Index: 14
#2Caterina ValentinoH-Index: 1
Last. Franca FerrariH-Index: 38
view all 11 authors...
Glioblastoma multiforme (GBM) is one of the most prevalent and aggressive brain tumors for which there is currently no cure. A novel composite nanosystem (CN), consisting of chitosan-coated Solid Lipid Nanoparticles (c-SLN) embedded in O-carboxymethyl chitosan (O-CMCS)-containing nanofibers (NFs), was proposed as a potential tool for the local delivery of lipophilic anti-proliferative drugs. Coacervation was selected as a solvent-free method for the preparation of stearic acid (SA) and behenic a...
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#1Barbara ViganiH-Index: 14
#2Caterina ValentinoH-Index: 1
Last. Franca FerrariH-Index: 38
view all 11 authors...
Injuries to the nervous system affect more than one billion people worldwide, and dramatically impact on the patient’s quality of life. The present work aimed to design and develop a gellan gum (GG)-based composite system for the local delivery of the neuroprotective sigma-1 receptor agonist, 1-[3-(1,1′-biphen)-4-yl] butylpiperidine (RC-33), as a potential tool for the treatment of tissue nervous injuries. The system, consisting of cross-linked electrospun nanofibers embedded in a RC-33-loaded f...
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#1Mária Budai-Szűcs (University of Szeged)H-Index: 12
#2Marco Ruggeri (UNIPV: University of Pavia)H-Index: 5
Last. Franca Ferrari (UNIPV: University of Pavia)H-Index: 38
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Periodontitis is a set of inflammatory conditions affecting the tissues surrounding the teeth predominantly sustained by bacterial infections. The aim of the work was the design and the development of scaffolds based on biopolymers to be inserted in the periodontal pocket to restore tissue integrity and to treat bacterial infections. Nanofibrous scaffolds were prepared by means of electrospinning. Gelatin was considered as base component and was associated to low and high molecular weight chitos...
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#1Eleonora Bianchi (UNIPV: University of Pavia)H-Index: 1
#2Marco Ruggeri (UNIPV: University of Pavia)H-Index: 5
Last. Franca Ferrari (UNIPV: University of Pavia)H-Index: 38
view all 8 authors...
The tendon is a highly aligned connective tissue that transmits force from muscle to bone. Each year, more than 32 million tendon injuries have been reported, in fact, tendinopathies represent at least 50% of all sports injuries, and their incidence rates have increased in recent decades due to the aging population. Current clinical grafts used in tendon treatment are subject to several restrictions and there is a significant demand for alternative engineered tissue. For this reason, innovative ...
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#1Dalila Miele (UNIPV: University of Pavia)H-Index: 5
#2Laura Catenacci (UNIPV: University of Pavia)H-Index: 18
Last. Maria Cristina Bonferoni (UNIPV: University of Pavia)H-Index: 43
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Collagen, thanks to its biocompatibility, biodegradability and weak antigenicity, is widely used in dressings and scaffolds, also as electrospun fibers. Its mechanical stability can be improved by adding polycaprolactone (PCL), a synthetic and biodegradable aliphatic polyester. While previously collagen/PCL combinations were electrospun in solvents such as hexafluoroisopropanol (HFIP) or trifluoroethanol (TFE), more recently literature describes collagen/PCL nanofibers obtained in acidic aqueous...
1 CitationsSource
#1Barbara ViganiH-Index: 14
#2Silvia RossiH-Index: 36
Last. Franca FerrariH-Index: 38
view all 6 authors...
In situ gelling drug delivery systems have gained enormous attention over the last decade. They are in a sol-state before administration, and they are capable of forming gels in response to different endogenous stimuli, such as temperature increase, pH change and the presence of ions. Such systems can be administered through different routes, to achieve local or systemic drug delivery and can also be successfully used as vehicles for drug-loaded nano- and microparticles. Natural, synthetic and/o...
2 CitationsSource
#1Marco RuggeriH-Index: 5
#2Eleonora BianchiH-Index: 1
Last. Franca FerrariH-Index: 38
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Chronic wounds, such as pressure ulcers, diabetic ulcers, venous ulcers and arterial insufficiency ulcers, are lesions that fail to proceed through the normal healing process within a period of 12 weeks. The treatment of skin chronic wounds still represents a great challenge. Wound medical devices (MDs) range from conventional and advanced dressings, up to skin grafts, but none of these are generally recognized as a gold standard. Based on recent developments, this paper reviews nanotechnology-b...
2 CitationsSource
#1Marta CicognaniH-Index: 1
#2Silvia Rossi (UNIPV: University of Pavia)H-Index: 36
Last. Franca Ferrari (UNIPV: University of Pavia)H-Index: 38
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The aim of the present work was the development of a novel glycosaminoglycan (GAG)-based injectable formulation intended for intra-articular administration that should best mimic the healthy synovial fluid. Hyaluronic acid (HA) was chosen among GAG polymers, since it is the most abundant component of the synovial fluid. A DoE (Design of Experiment) approach was used for the development of a formulation containing two HA (very high (VHMW) and low (LMW) molecular weight) grades. The rationale for ...
1 CitationsSource
#1Laura Catenacci (UNIPV: University of Pavia)H-Index: 18
#2Giorgio Marrubini (UNIPV: University of Pavia)H-Index: 15
Last. Maria Cristina Bonferoni (UNIPV: University of Pavia)H-Index: 43
view all 9 authors...
Polymeric micelles based on amphiphilic polysaccharides have some advantages as a carrier of poorly soluble lipophilic drugs thanks to their characteristic "core–shell" structure. Previously, ionic polymeric micelles based on chitosan and fatty acids have been developed. The aim of the present study was the preparation and characterization of hyaluronic acid (HA) derivatives by direct ionic interaction between the HA carboxylic groups and the amine groups of dodecyl amine (DDA) and hexadecyl ami...
1 CitationsSource
#1Giuseppina Sandri (UNIPV: University of Pavia)H-Index: 35
#2Angela Faccendini (UNIPV: University of Pavia)H-Index: 8
Last. Franca Ferrari (UNIPV: University of Pavia)H-Index: 38
view all 11 authors...
The increase in life expectancy and the increasing prevalence of diabetic disease and venous insufficiency lead to the increase of chronic wounds. The prevalence of ulcers ranges from 1% in the adult population to 3–5% in the over 65 years population, with 3–5.5% of the total healthcare expenditure, as recently estimated. The aim of this work was the design and the development of electrospun scaffolds, entirely based on biopolymers, loaded with montmorillonite (MMT) or halloysite (HNT) and inten...
6 CitationsSource