Alexander Rauscher
University of British Columbia
Phase (waves)Internal medicinePathologyMagnetic resonance imagingDiffusion MRIPsychologySusceptibility weighted imagingCognitionChemistryMaterials scienceContrast (vision)Corpus callosumMyelinMultiple sclerosisWhite matterNuclear medicineMyelin waterNuclear magnetic resonanceNeuroimagingMedicine
156Publications
32H-index
3,206Citations
Publications 159
Newest
#1Jacob L. Stubbs (UBC: University of British Columbia)H-Index: 6
#2Andrea A. Jones (UBC: University of British Columbia)H-Index: 12
Last. William J. Panenka (UBC: University of British Columbia)H-Index: 21
view all 18 authors...
ImportanceHomeless or precariously housed individuals live with poor health and experience premature mortality compared to the general population. With an increasing average age among this demographic, syndromes associated with neurogenerative disease are also increasing. Quantitative MRI measures may help define the roles of age and risk factors for poor brain health among these individuals. null ObjectiveTo evaluate whether MRI measures of brain structure are differentially associated with age...
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#1Tobias Zrzavy (Medical University of Vienna)H-Index: 11
#2Alice Wielandner (Medical University of Vienna)H-Index: 5
Last. Gregor Kasprian (Medical University of Vienna)H-Index: 29
view all 10 authors...
Source
#1Tobias Zrzavy (Medical University of Vienna)H-Index: 11
#2Alice Wielandner (Medical University of Vienna)H-Index: 5
Last. Gregor Kasprian (Medical University of Vienna)H-Index: 29
view all 10 authors...
Technical improvements in magnetic resonance imaging (MRI) acquisition, such as higher field strength and optimized sequences, lead to better multiple sclerosis (MS) lesion detection and characterization. Multiplication of 3D-FLAIR with 3D-T2 sequences (FLAIR2) results in isovoxel images with increased contrast-to-noise ratio, increased white–gray-matter contrast, and improved MS lesion visualization without increasing MRI acquisition time. The current study aims to assess the potential of 3D-FL...
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#1Christian Kames (UBC: University of British Columbia)H-Index: 6
#2Jonathan Doucette (UBC: University of British Columbia)H-Index: 6
Last. Alexander Rauscher (UBC: University of British Columbia)H-Index: 32
view all 4 authors...
Purpose null To develop a deep neural network to recover filtered phase from clinical MR phase images to enable the computation of QSMs. null Methods null Eighteen deep learning networks were trained to recover combinations of 13 SWI phase-filtering pipelines. SWI-filtered data were computed offline from five multiorientation, multiecho MRI scans yielding 132 3D volumes (118/7/7 training/validation/testing). Two experiments were conducted to show the efficacy of the networks. First, using QSM pr...
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#1Daniel Ontaneda (Cleveland Clinic)H-Index: 23
#2Praneeta Raza (Cleveland Clinic)H-Index: 3
Last. Christina J. Azevedo (SC: University of Southern California)H-Index: 14
view all 22 authors...
Although multiple sclerosis (MS) has traditionally been considered a white matter disease, extensive research documents the presence and importance of gray matter injury including cortical and deep regions. The deep gray matter (DGM) exhibits a broad range of pathology and is uniquely suited to study the mechanisms and clinical relevance of tissue injury in MS using magnetic resonance techniques. DGM injury has been associated with clinical and cognitive disability. Recently, MRI characterizatio...
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#1Irene M. Vavasour (UBC: University of British Columbia)H-Index: 31
#2Kimberley Chang (UBC: University of British Columbia)H-Index: 3
Last. Cornelia LauleH-Index: 28
view all 10 authors...
Background and purpose null Myelin water fraction (MWF) is a histopathologically validated in vivo myelin marker. As MWF is the proportion of water with a short T2 relative to the total water, increases in water from edema and inflammation may confound MWF determination in multiple sclerosis (MS) lesions. Total water content (TWC) measurement enables calculation of absolute myelin water content (MWC) and can be used to distinguish edema/inflammation from demyelination. We assessed what influence...
Source
#1Heather A. Baitz (SFU: Simon Fraser University)H-Index: 4
#2Paul W. Jones (SFU: Simon Fraser University)H-Index: 1
Last. William J. Panenka (UBC: University of British Columbia)H-Index: 21
view all 20 authors...
The Iowa Gambling Task (IGT) is a widely used measure of decision making, but its value in signifying behaviors associated with adverse, "real-world" consequences has not been consistently demonstrated in persons who are precariously housed or homeless. Studies evaluating the ecological validity of the IGT have primarily relied on traditional IGT scores. However, computational modeling derives underlying component processes of the IGT, which capture specific facets of decision making that may be...
Source
#1Jonathan Doucette (UBC: University of British Columbia)H-Index: 6
#2Christian Kames (UBC: University of British Columbia)H-Index: 6
Last. Alexander Rauscher (UBC: University of British Columbia)H-Index: 32
view all 3 authors...
Bayesian parameter estimation methods are robust techniques for quantifying properties of physical systems which cannot be observed directly. In estimating such parameters, one first requires a physics model of the phenomenon to be studied. Often, such a model follows a series of assumptions to make parameter inference feasible. When simplified models are used for inference, however, systematic differences between model predictions and observed data may propagate throughout the parameter estimat...
#1Marita Partanen (UBC: University of British Columbia)H-Index: 7
#2Daniel Kim (Boston Children's Hospital)H-Index: 4
Last. Deborah Giaschi (UBC: University of British Columbia)H-Index: 27
view all 5 authors...
This study examined changes in white matter microstructure and grey matter volume, cortical thickness, and cortical surface area before and after reading intervention. Participants included 22 average readers and 13 dyslexic readers (8-9 years old in third grade); the dyslexic readers were enrolled in reading intervention programs at their elementary school. Participants completed scans of diffusion tensor imaging and T1-weighted MRI before and after 3 months of instruction. An a priori region o...
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#1Christoph Birkl (UBC: University of British Columbia)H-Index: 8
#2Jonathan Doucette (UBC: University of British Columbia)H-Index: 6
Last. Alexander Rauscher (UBC: University of British Columbia)H-Index: 32
view all 5 authors...
Purpose The multi-exponential T2 decay of the MRI signal from cerebral white matter can be separated into short T2 components related to myelin water and long T2 components related to intracellular and extracellular water. In this study, we investigated to what degree the apparent myelin water fraction (MWF) depends on the angle between white matter fibers and the main magnetic field. Methods Maps of the apparent MWF were acquired using multi-echo Carr-Purcell-Meiboom-Gill and gradient-echo spin...
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