Man Hai Liu
China University of Science and Technology
Bone morphogenetic protein 7EndocrinologyGene expressionBone morphogenetic protein 6ChemistryBone morphogenetic protein 8AOsteoblastCoumestrolPuerarinLipopolysaccharideRANKLIsoflavonesOsteoprotegerinIcariinDaidzeinChondrocyteBone morphogenetic protein 2Bone morphogenetic proteinNitric oxideCell biology
Publications 7
#1Shiow Yunn Sheu (TMU: Taipei Medical University)H-Index: 15
#2Yi Wen Hong (TMU: Taipei Medical University)H-Index: 1
Last. Cherng-Jyh Ke (NCTU: National Chiao Tung University)H-Index: 11
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Background Hypoxia could lead to microglia activation and inflammatory mediators’ overproduction. These inflammatory molecules could amplify the neuroinflammatory process and exacerbate neuronal injury. The aim of this study is to find out whether harpagoside could reduce hypoxia-induced microglia activation.
10 CitationsSource
#1Shiow Yunn SheuH-Index: 15
#2Chia chung Tsai (TMU: Taipei Medical University)H-Index: 1
Last. Man Ger Sun (UWO: University of Western Ontario)H-Index: 3
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BACKGROUND: Estrogen deficiency results in loss of bone mass. Phytoestrogens are plant-derived non-steroidal compounds with estrogen-like activity that bind to estrogen receptors. The main aim of this study was to investigate the effect of the phytoestrogen puerarin on adult mouse osteoblasts. METHODS: Osteoblast cells were harvested from 8-month old female imprinting control region (ICR) mice. The effects of puerarin stimulation on the proliferation, differentiation and maturation of osteoblast...
19 CitationsSource
#1Man Hai Liu (TMU: Taipei Medical University)H-Index: 7
#2Fon-Yih Tsuang (TMU: Taipei Medical University)H-Index: 7
Last. Chi Ming Shih (TMU: Taipei Medical University)H-Index: 1
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Abstract Objectives: Estrogen replacement therapy can decrease the risk of developing Alzheimer’s disease. Phytoestrogens have been proposed as potential alternatives to estrogen replacement therapy. The purpose of this study was to evaluate the in vitro protective effects of coumestrol on mice astrocytes. Methods: Different concentrations of coumestrol were tested for their protective efficacy against two toxic insults, lipopolysaccharide (LPS) and amyloid-beta peptide, on astrocytes. The mitoc...
8 CitationsSource
#1Tsai Pei Hsieh (TMU: Taipei Medical University)H-Index: 2
#2Shiow Yunn Sheu (TMU: Taipei Medical University)H-Index: 15
Last. Man Hai Liu (TMU: Taipei Medical University)H-Index: 7
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Abstract Epimedii herba is one of the most frequently used herbs in formulas prescribed for the treatment of osteoporosis in China. The main active flavonoid glucoside extracted from Epimedium pubescens is Icariin, which has been reported to enhance bone healing and reduce osteoporosis occurrence. However, the detailed molecular mechanisms remain unclear. In this present study, we examine the molecular mechanisms of icariin by using primary osteoblast cell cultures obtained from adult mice. The ...
159 CitationsSource
#1Man Hai Liu (TMU: Taipei Medical University)H-Index: 7
#2Jui-Sheng Sun (TMU: Taipei Medical University)H-Index: 41
Last. Ming-Hong Chen (NYMU: National Yang-Ming University)H-Index: 16
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Abstract Septic arthritis is an inflammatory arthropathy characterized by degeneration of articular cartilage. Icariin, the main active flavonoid glucoside isolated from Epimedium pubescens , is used as antirheumatics (or antiinflammatory), tonics, and aphrodisiacs in traditional Chinese medicine. In this study, we used lipopolysaccharide (LPS) to simulate the in vitro inflammatory response of chondrocytes during septic arthritis. Our hypothesis is that the icariin can protect chondrocytes from ...
82 CitationsSource
#1Man Hai LiuH-Index: 7
#2Yu Shan LinH-Index: 1
Last. Jui-Sheng Sun (NTU: National Taiwan University)H-Index: 41
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Abstract Introduction: Alzheimer's disease is the common cause of dementia in old people. The pathological hallmarks of Alzheimer's disease include neuronal loss, deposition of amyloid-β, and presence of neurofibrillary tangles. The endogenous steroid estrogen has been shown to affect neuronal growth, differentiation and survival, while isoflavones also have a neuroprotective effect on human cortical neurons. Daidzein, however, has a superior neuron-protective effect to other isoflavones. The pr...
26 CitationsSource
#1Jui-Sheng Sun (NYMU: National Yang-Ming University)H-Index: 41
#2Ya Ying Li (TMU: Taipei Medical University)H-Index: 1
Last. Shiow Yunn Sheu (TMU: Taipei Medical University)H-Index: 15
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Estrogen replacement therapy has been shown to reduce postmenopausal osteoporosis. In the present study, we examined the effects of the phytoestrogen coumestrol on neonatal and adult osteoblasts metabolism. Two different sources of osteoblast cells (neonatal mice calvaria and adult mice long bone) cultures were used in this study. The effects of coumestrol on the cellular activities were analyzed by the mitochondrial tetrazolium (MTT) assay, secretion of alkaline phosphatase (ALP), intracellular...
11 CitationsSource
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