Akihiko Taniguchi
Okayama University
Internal medicineRetinoid X receptorChemokinePulmonary complianceSurgeryPathologyInterleukin 23Retrospective cohort studyReceptorChemistryImmunologyFEV1/FVC ratioBiopsyAsthmaLung cancerPancreatic elastaseExacerbationLungNeutrophiliaBronchoalveolar lavageIdiopathic pulmonary fibrosisRAGE (receptor)ElastaseAdenocarcinomaAirway hyperresponsivenessCancer researchVital capacityPartial agonistMedicineGastroenterology
40Publications
10H-index
242Citations
Publications 40
Newest
#1Hisao HigoH-Index: 6
#2Kadoaki OhashiH-Index: 1
Last. Kazuya NishiiH-Index: 5
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#1Daisuke Morichika (Okayama University)H-Index: 8
#2Akihiko Taniguchi (Okayama University)H-Index: 10
Last. Masayuki Hanaoka (Shinshu University)H-Index: 28
view all 15 authors...
Background IL-33, which is known to induce type 2 immune responses via group 2 innate lymphoid cells, has been reported to contribute to neutrophilic airway inflammation in chronic obstructive pulmonary disease. However, its role in the pathogenesis of emphysema remains unclear. Methods We determined the role of interleukin (IL)-33 in the development of emphysema using porcine pancreas elastase (PPE) and cigarette smoke extract (CSE) in mice. First, IL-33-/- mice and wild-type (WT) mice were giv...
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#1Toshiyuki AokageH-Index: 10
#2Mizuki SeyaH-Index: 1
Last. Hiromichi NaitoH-Index: 10
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#2Naohiro OdaH-Index: 8
Last. Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
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Abstract Cryptococcosis is an invasive mycosis that has become increasingly prevalent in immunocompromised patients. Pregnant women are also one of the risk populations for cryptococcosis. Reversal of Th2 to Th1 response following resolution of immunosuppression during the postpartum period can lead to overt clinical manifestations of a previously silent infection, resembling an immune reconstitution inflammatory syndrome. Here, we report a case of a 30-year-old woman who had an exacerbation of ...
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#1Sachi Okawa (Okayama University)
#1Sachi Okawa (Okayama University)H-Index: 3
Last. Katsuyuki Kiura (Okayama University)H-Index: 68
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A 68-year-old man presented with a solid mass at the left renal pelvis and ureter with multiple systemic lymphadenopathies and a mass with a cavity in the right lower lobe of the lung. While a transbronchial lung biopsy revealed no malignancy, a biopsy of the renal pelvis showed marginal zone lymphoma with polyclonal IgG4-positive cells. The serum IgG4 level and presence of a bilateral orbital mass suggested Mikulicz disease.The lesions shrank following the administration of steroids. A rebiopsy...
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#1Shunichi Kawamura (Okayama University)
#2Toshio Kubo (Okayama University)H-Index: 18
Last. Masahiro Tabata (Okayama University)H-Index: 34
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A 62-year-old woman with edema and color changes in her fingers underwent computed tomography (CT); slight interstitial changes were detected in the lungs with multiple tumors in the anterior and hilar region of the liver. Based on the blood test findings, she was diagnosed with interstitial pneumonia associated with systemic sclerosis. Ultrasound-guided biopsy from the hepatic hilar lymph node revealed poorly differentiated serous adenocarcinoma cells. High serum CA-125 levels suggested primary...
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#1Kota Araki (Okayama University)H-Index: 4
#2Rie Kinoshita (Okayama University)H-Index: 11
Last. Masakiyo Sakaguchi (Okayama University)H-Index: 50
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In patients with interstitial pneumonia, pulmonary fibrosis is an irreversible condition that can cause respiratory failure. Novel treatments for pulmonary fibrosis are necessary. Inflammation is thought to activate lung fibroblasts, resulting in pulmonary fibrosis. Of the known inflammatory molecules, we have focused on S100A8/A9 from the onset of inflammation to the subsequent progression of inflammation. Our findings confirmed the high expression of S100A8/A9 in specimens from patients with p...
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#1Satoru Senoo (Okayama University)H-Index: 5
#2Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
Last. Katsuyuki Kiura (Okayama University)H-Index: 68
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BACKGROUND Nintedanib is a multi-kinase inhibitor approved for idiopathic pulmonary fibrosis (IPF); however, its efficacy and safety for patients with IPF and restricted pulmonary function remain unclear. Therefore, the objective of this study was to determine the efficacy and safety of nintedanib for patients with IPF and forced vital capacity (FVC) ≤ 50%. METHODS This was a multi-center retrospective study performed by the Okayama Respiratory Disease Study Group. Patients were allocated into F...
1 CitationsSource
#1Satoru Senoo (Okayama University)H-Index: 5
#2Akihiko Taniguchi (Okayama University)H-Index: 10
Last. Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
view all 9 authors...
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#1Hisao Higo (Okayama University)H-Index: 6
#2Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
Last. Katsuyuki Kiura (Okayama University)H-Index: 68
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Abstract Background Pirfenidone suppresses the decline of forced vital capacity (FVC) in patients with idiopathic pulmonary fibrosis (IPF). However, IPF progresses in some patients despite treatment. We analyzed patients with meaningful FVC declines during pirfenidone treatment and explored the factors predictive of disease progression after FVC decline. Methods This study was a retrospective, multicenter, observational study conducted by the Okayama Respiratory Disease Study Group. We defined i...
1 CitationsSource