Ki Taek Nam
Yonsei University
AnatomyCancerInternal medicineEndocrinologyPathologyCellMolecular biologyChemistryIn vivoHelicobacter pyloriIntestinal metaplasiaMetaplasiaStomachGastric mucosaToxicityCancer researchCarcinogenesisCell growthGastric chief cellMedicineBiologyCell biologyPharmacology
157Publications
32H-index
3,205Citations
Publications 156
Newest
#1Minjeong Kim (Ewha Womans University)H-Index: 7
#2Sumin Hur (Yonsei University)H-Index: 1
Last. Kyung-Min Lim (Ewha Womans University)H-Index: 32
view all 8 authors...
Liver fibrosis is part of the wound healing process to help the liver recover from the injuries caused by various liver-damaging insults. However, liver fibrosis often progresses to life-threatening cirrhosis and hepatocellular carcinoma. To overcome the limitations of current in vivo liver fibrosis models for studying the pathophysiology of liver fibrosis and establishing effective treatment strategies, we developed a new mouse model of liver fibrosis using polyhexamethylene guanidine phosphate...
Source
#1Haengdueng Jeong (Yonsei University)H-Index: 6
#2Buhyun Lee (Yonsei University)H-Index: 5
Last. Ah-Ra Jang (Chonnam National University)H-Index: 2
view all 18 authors...
Abstract null BACKGROUND & AIMS null WAP four-disulfide core domain protein 2 (WFDC2), also known as human epididymis protein 4 (HE4), is a small secretory protein that is highly expressed in fibrosis and human cancers, particularly in the ovaries, lungs, and stomach. However, the role of WFDC2 in carcinogenesis is not fully understood. The present study aimed to investigate the role of WFDC2 in gastric carcinogenesis using preneoplastic metaplasia models. null METHODS null Three spasmolytic pol...
Source
#1Soon Kyeong Kwon (Yonsei University)H-Index: 15
#2Jun Chul Park (Yonsei University)H-Index: 24
Last. Sung Hee Kim (Yonsei University)
view all 16 authors...
Objective null Gastric cancer (GC) is a leading cause of cancer-related mortality. Although microbes besides Helicobacter pylori may also contribute to gastric carcinogenesis, wild-type germ-free (GF) mouse models investigating the role of human gastric microbiota in the process are not yet available. We aimed to evaluate the histopathological features of GF mouse stomachs transplanted with gastric microbiota from patients with different gastric disease states and their relationships with the mi...
1 CitationsSource
#1Yeeun Choi (Yonsei University)H-Index: 5
#2Min-Ji SongH-Index: 6
Last. Seung Hoi Koo (KU: Korea University)H-Index: 41
view all 13 authors...
Background & Aims null The liver is the major organ for metabolizing lipids, and malfunction of the liver leads to various diseases. Nonalcoholic fatty liver disease is rapidly becoming a major health concern worldwide and is characterized by abnormal retention of excess lipids in the liver. CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein that regulates higher-order chromatin organization and is involved in various gene regulation processes. Here, we sought to determine the...
Source
#1Se Yong Park (SNU: Seoul National University)
#2Kyu Sup AnH-Index: 2
Last. Yeo Sung Yoon (SNU: Seoul National University)H-Index: 25
view all 11 authors...
Background null Particulate matter (PM) is one of the principal causes of human respiratory disabilities resulting from air pollution. Animal models have been applied to discover preventive and therapeutic drugs for lung diseases caused by PM. However, the induced severity of lung injury in animal models using PM varies from study to study due to disparities in the preparation of PM, and the route and number of PM administrations. In this study, we established an in vivo model to evaluate PM-ind...
Source
#1Sang-Ho Jeong (Gyeongsang National University)H-Index: 19
#2Miyeong Park (Gyeongsang National University)H-Index: 2
Last. James R. Goldenring (Vandy: Vanderbilt University)H-Index: 83
view all 14 authors...
INTRODUCTION There have been few studies about gene differences between patients with diffuse-type gastric cancer and those with intestinal-type gastric cancer. The aim of this study was to compare the transcriptomes of signet ring cell gastric cancer (worst prognosis in diffuse-type) and well-differentiated gastric cancer (best prognosis in intestinal-type); NUDC was identified, and its prognostic role was studied. MATERIALS AND METHODS We performed next-generation sequencing with 5 well-differ...
Source
#1So Hee Hong (Catholic University of Korea)
#2Hanseul Oh (Korea Research Institute of Bioscience and Biotechnology)H-Index: 5
Last. Jung Joo Hong (Korea Research Institute of Bioscience and Biotechnology)H-Index: 21
view all 36 authors...
Since the emergence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), various vaccines are being developed, with most vaccine candidates focusing on the viral spike protein. Here, we developed a previously unknown subunit vaccine comprising the receptor binding domain (RBD) of the spike protein fused with the tetanus toxoid epitope P2 (RBD-P2) and tested its efficacy in rodents and nonhuman primates (NHPs). We also investigated whether the SARS-CoV-2 nucleocapsid protein (N) could...
1 CitationsSource
#1Ji Eun Lee (Kyung Hee University)H-Index: 12
#2Sungjin Ahn (SNU: Seoul National University)H-Index: 7
Last. Jae Sung Hwang (Kyung Hee University)H-Index: 21
view all 13 authors...
Melanoma is a disease with a high recurrence rate and poor prognosis; therefore, the need for targeted therapeutics is steadily increasing. Oligodendrocyte transcription factor2 (Olig2) is a basic helix-loop-helix transcription factor that is expressed in the central nervous system during embryonic development. Olig2 is overexpressed in various malignant cell lines such as lung carcinoma, glioma and melanoma. Olig2 is known as a key transcription factor that promotes tumor growth in malignant gl...
Source
#1Jee hyun Hwang (Ewha Womans University)H-Index: 1
#2Haengdueng Jeong (Yonsei University)H-Index: 6
Last. Kyung-Min Lim (Ewha Womans University)H-Index: 32
view all 5 authors...
Abstract Biocides are widely used in household products. Humans are exposed to biocides through dermal, inhalational, and oral routes. However, information on the dermal and inhalational toxicity of biocides is limited. We evaluated the effects of biocides on the skin and airways using the reconstructed human epidermis model KeraSkin™ and the airway model SoluAirway™. We determined the irritancy of 11 commonly used biocides (1,2-benzisothiazol-3(2H)-one [BIT], 2-phenoxyethanol [PE], zinc pyrithi...
1 CitationsSource
#1Ki Taek NamH-Index: 32
#3Seok Jin OhH-Index: 13
Source