Kenta Masuda
University of Oxford
GeneCancerInternal medicineGermline mutationOncologyDNA methylationLynch syndromeEndometrial cancerCarcinomaMetastasisMicrosatellite instabilityOvarian cancerOncogeneGynecologyEpigeneticsCancer researchBreast cancerGeneticsCarcinogenesisBioinformaticsDNA mismatch repairMedicineBiologyCancer cell
74Publications
22H-index
990Citations
Publications 72
Newest
#1Mara ArtibaniH-Index: 7
#2Kenta Masuda (University of Oxford)H-Index: 22
Last. Ahmed Ashour AhmedH-Index: 28
view all 31 authors...
Similar to tumor initiating cells (TICs), minimal residual disease (MRD) is capable of re-initiating tumors and causing recurrence. However, the molecular characteristics of solid tumor MRD cells and drivers of their survival have remained elusive. Here we performed dense multi-region transcriptomics analysis of paired biopsies from 17 ovarian cancer patients before and after chemotherapy. We reveal that while MRD cells share important molecular signatures with TICs, they are also characterized ...
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Abstract null null Locally advanced cervical cancer occasionally induces pyometra, but there have been no reports of meningitis where pyometra is the cause of infection. Here, we report a case of Listeria monocytogenes meningitis related to pyometra during concurrent chemoradiotherapy (CCRT) in a cervical cancer patient. The patient, a 77-year-old woman, was diagnosed with Stage IIB (FIGO 2018) cervical adenocarcinoma, and CCRT was initiated. Pyometra was exacerbated during CCRT, and after her f...
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#1Yusuke Kobayashi (Keio: Keio University)H-Index: 23
#2Akira Hirasawa (Okayama University)H-Index: 20
Last. Daisuke Aoki (Keio: Keio University)H-Index: 58
view all 12 authors...
Background Risk-reducing salpingo-oophorectomy is performed for the primary prevention of ovarian cancer in patients with hereditary breast-ovarian cancer syndrome. We performed risk-reducing salpingo-oophorectomy for the first time in Japan in 2008, and we experienced 20 cases of risk-reducing salpingo-oophorectomy through 2019. In the past, the use of risk-reducing salpingo-oophorectomy in Japan was restricted because it was not covered by a Japanese National Health Insurance. Since April 2020...
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#1Yusuke Kobayashi (Keio: Keio University)H-Index: 23
#2Takashi Takeda (Keio: Keio University)H-Index: 7
Last. Daisuke Aoki (Keio: Keio University)H-Index: 58
view all 15 authors...
Abstract Patients with Cowden syndrome exhibit mucocutaneous lesions, hamartomatous polyposis of the gastrointestinal tract, and macrocephaly, often complicated by malignant tumors, such as breast, thyroid, and uterine cancers. Autism spectrum and epilepsy have been known as neuropsychiatric symptoms associated with Cowden syndrome; however, to the best of our knowledge, there is no report on cases complicated by schizophrenia. Here, we report a first case of Cowden syndrome complicated by schiz...
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#1Tomoko Kaneyasu (JFCR: Japanese Foundation for Cancer Research)H-Index: 1
#2Seiichi Mori (JFCR: Japanese Foundation for Cancer Research)H-Index: 33
Last. Seigo Nakamura (Showa University)H-Index: 28
view all 33 authors...
Panel sequencing of susceptibility genes for hereditary breast and ovarian cancer (HBOC) syndrome has uncovered numerous germline variants; however, their pathogenic relevance and ethnic diversity remain unclear. Here, we examined the prevalence of germline variants among 568 Japanese patients with BRCA1/2-wildtype HBOC syndrome and a strong family history. Pathogenic or likely pathogenic variants were identified on 12 causal genes for 37 cases (6.5%), with recurrence for 4 SNVs/indels and 1 CNV...
5 CitationsSource
#1Zhiyuan Hu (University of Oxford)H-Index: 4
#2Mara Artibani (University of Oxford)H-Index: 7
Last. Ahmed Ashour Ahmed (University of Oxford)H-Index: 28
view all 27 authors...
Summary The inter-differentiation between cell states promotes cancer cell survival under stress and fosters non-genetic heterogeneity (NGH). NGH is, therefore, a surrogate of tumor resilience but its quantification is confounded by genetic heterogeneity. Here we show that NGH in serous ovarian cancer (SOC) can be accurately measured when informed by the molecular signatures of the normal fallopian tube epithelium (FTE) cells, the cells of origin of SOC. Surveying the transcriptomes of ∼6,000 FT...
34 CitationsSource
#1Takeshi Motohara (University of Oxford)H-Index: 13
#2Kenta Masuda (University of Oxford)H-Index: 22
Last. Ahmed Ashour Ahmed (University of Oxford)H-Index: 28
view all 15 authors...
Metastasis is a complex multistep process that involves critical interactions between cancer cells and a variety of stromal components in the tumor microenvironment, which profoundly influence the different aspects of the metastatic cascade and organ tropism of disseminating cancer cells. Ovarian cancer is the most lethal gynecological malignancy and is characterized by peritoneal disseminated metastasis. Evidence has demonstrated that ovarian cancer possesses specific metastatic tropism for the...
49 CitationsSource
#1Kiyoko Umene (Keio: Keio University)H-Index: 17
#2Kouji Banno (Keio: Keio University)H-Index: 28
Last. Daisuke Aoki (Keio: Keio University)H-Index: 58
view all 14 authors...
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#1Yiyan Zheng (University of Oxford)H-Index: 5
#2R. Sethi (SGC: Structural Genomics Consortium)H-Index: 5
Last. Ahmed Ashour Ahmed (University of Oxford)H-Index: 28
view all 31 authors...
Though used widely in cancer therapy, paclitaxel only elicits a response in a fraction of patients. A strong determinant of paclitaxel tumor response is the state of microtubule dynamic instability. However, whether the manipulation of this physiological process can be controlled to enhance paclitaxel response has not been tested. Here, we show a previously unrecognized role of the microtubule-associated protein CRMP2 in inducing microtubule bundling through its carboxy terminus. This activity i...
27 CitationsSource
#1Ryuichiro Okawa (Keio: Keio University)H-Index: 2
#2Kouji Banno (Keio: Keio University)H-Index: 28
Last. Daisuke Aoki (Keio: Keio University)H-Index: 58
view all 15 authors...
: Epigenetic regulatory mechanisms are a current focus in studies investigating cancer. Chromatin remodeling alters chromatin structure and regulates gene expression, and aberrant chromatin remodeling is involved in carcinogenesis. AT-rich interactive domain-containing protein 1A (ARID1A) and SWItch/sucrose non-fermentable-related, matrix-associated, actin-dependent regulator of chromatin, subfamily a, member 4 are remodeling factors that are mutated in numerous types of cancer. In gynecological...
3 CitationsSource