Ian J. Douglas
University of London
EpidemiologyInternal medicineSurgeryDemographyRate ratioCode (cryptography)Intensive care medicinePediatricsProgramming languageCohort studyHazard ratioPopulationRead codesIn patientComputer scienceIncidence (epidemiology)Confidence intervalProportional hazards modelMedicineCohort
Publications 253
#1A.R. Green (University of Oxford)H-Index: 34
#2Helen J Curtis (University of Oxford)H-Index: 19
Last. Ben Goldacre (University of Oxford)H-Index: 39
view all 41 authors...
BackgroundWhile the vaccines against COVID-19 are considered to be highly effective, COVID-19 vaccine breakthrough is likely and a small number of people will still fall ill, be hospitalised, or die from COVID-19, despite being fully vaccinated. With the continued increase in numbers of positive SARS-CoV-2 tests, describing the characters of individuals who have experienced a COVID-19 vaccine breakthrough could be hugely important in helping to determine who may be at greatest risk. null MethodW...
#2Helen J Curtis (University of Oxford)H-Index: 19
#3Brian MacKenna (University of Oxford)H-Index: 13
Last. Peter Inglesby (University of Oxford)H-Index: 12
view all 31 authors...
Background null Early in the COVID-19 pandemic, the National Health Service (NHS) recommended that appropriate patients anticoagulated with warfarin should be switched to direct-acting oral anticoagulants (DOACs), requiring less frequent blood testing. Subsequently, a national safety alert was issued regarding patients being inappropriately coprescribed two anticoagulants following a medication change and associated monitoring. null Objective null To describe which people were switched from warf...
BACKGROUND Thromboembolism has been reported as a consequence of severe COVID-19. Although warfarin is a commonly used anticoagulant, it acts by antagonising vitamin K, which is low in patients with severe COVID-19. To date, the clinical evidence on the impact of regular use of warfarin on COVID-19-related thromboembolism is lacking. METHODS On behalf of NHS England, we conducted a population-based cohort study investigating the association between warfarin and COVID-19 outcomes compared with di...
#1William J Hulme (University of Oxford)H-Index: 11
#2Elizabeth Williamson (Lond: University of London)H-Index: 9
Last. Ben Goldacre (University of Oxford)H-Index: 39
view all 41 authors...
Background: The UK COVID-19 vaccination programme delivered both the BNT162b2 mRNA (Pfizer-BioNTech) and the ChAdOx1 (Oxford-AstraZeneca) vaccines during overlapping periods, providing a rare opportunity to emulate a trial that directly compares both vaccines using routinely-collected NHS data. Frontline Health and Social Care workers comprise a useful population to assess comparative effectiveness due to early vaccine eligibility and relatively high post-vaccination transmission risk due to occ...
#1Marc F Österdahl ('KCL': King's College London)
#2Sarah-Jo Sinnott (Lond: University of London)H-Index: 10
Last. Angel Wong (Lond: University of London)H-Index: 3
view all 6 authors...
Abstract null Background null Treatment for hypertension improves cardiovascular outcomes. Frailty is common in people treated for hypertension, and associated with increases in adverse drug effects, potentially including falls resulting in fractures. We aimed to determine the association between baseline frailty and fractures in patients initiated on antihypertensive treatment. null Methods null We conducted a retrospective cohort study using United Kingdom primary care data, including new-user...
#1Patrick Bidulka (Lond: University of London)H-Index: 3
#2Stephen O'Neill (Lond: University of London)H-Index: 11
Last. Laurie A. Tomlinson (Lond: University of London)H-Index: 28
view all 13 authors...
Introduction null For people with type 2 diabetes mellitus (T2DM) who require an antidiabetic drug as an add-on to metformin, there is controversy about whether newer drug classes such as dipeptidyl peptidase-4 inhibitors (DPP4i) or sodium-glucose co-transporter-2 inhibitors (SGLT2i) reduce the risk of long-term complications compared with sulfonylureas (SU). There is widespread variation across National Health Service Clinical Commissioning Groups (CCGs) in drug choice for second-line treatment...
#1Helen J Curtis (University of Oxford)H-Index: 19
#2Brian MacKenna (University of Oxford)H-Index: 13
Last. Ben Goldacre (University of Oxford)H-Index: 39
view all 35 authors...
Background null The COVID-19 pandemic has disrupted healthcare activity globally. The NHS in England stopped most non-urgent work by March 2020, but later recommended that services should be restored to near-normal levels before winter where possible. The authors are developing the OpenSAFELY NHS Service Restoration Observatory , using data to describe changes in service activity during COVID-19, and reviewing signals for action with commissioners, researchers and clinicians. Here we report phas...
#1Helen J Curtis (University of Oxford)H-Index: 19
#2Peter Inglesby (University of Oxford)H-Index: 12
Last. Ben Goldacre (University of Oxford)H-Index: 39
view all 45 authors...
BACKGROUND: On 8 December 2020 NHS England administered the first COVID-19 vaccination. AIM: To describe trends and variation in vaccine coverage in different clinical and demographic groups in the first 100 days of the vaccine rollout. DESIGN AND SETTING: With the approval of NHS England, a cohort study was conducted of 57.9 million patient records in general practice in England, in situ and within the infrastructure of the electronic health record software vendors EMIS and TPP using OpenSAFELY...
#1Brian MacKenna (University of Oxford)H-Index: 13
#2Nicholas A. Kennedy (University of Exeter)H-Index: 42
Last. Jeremy P Brown (Lond: University of London)H-Index: 15
view all 48 authors...
ABSTRACT null Background null It is unclear if people with immune-mediated inflammatory diseases (IMIDs) (joint, bowel and skin) and on immune modifying therapy have increased risk of serious COVID-19 outcomes. null Methods null With the approval of NHS England we conducted a cohort study, using OpenSAFELY, analysing routinely-collected primary care data linked to hospital admission, death and previously unavailable hospital prescription data. We used Cox regression (adjusting for confounders) t...
#1Daniel Grint (Lond: University of London)H-Index: 16
#2Kevin Wing (Lond: University of London)H-Index: 16
Last. Alex J Walker (University of Oxford)H-Index: 23
view all 37 authors...
BACKGROUND: The SARS-CoV-2 alpha variant (B.1.1.7) is associated with higher transmissibility than wild type virus, becoming the dominant variant in England by January 2021. We aimed to describe the severity of the alpha variant in terms of the pathway of disease from testing positive to hospital admission and death. METHODS: With the approval of NHS England, we linked individual-level data from primary care with SARS-CoV-2 community testing, hospital admission, and ONS all-cause death data. We ...
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