Ian R. Ellis
University of Dundee
CancerInternal medicineCell migrationPathologyCellMolecular biologyMatrix (biology)FetusChemistryExtracellular matrixImmunologyWound healingFibroblastType I collagenFibroblast migrationCancer researchGene isoformBiochemistryMedicineProtein kinase BCell cultureFibronectinBiologyCell biology
61Publications
19H-index
1,214Citations
Publications 60
Newest
#1Huda Alkhadar (Dund.: University of Dundee)H-Index: 2
#2Michaelina Macluskey (Dund.: University of Dundee)H-Index: 14
Last. Ian R. Ellis (Dund.: University of Dundee)H-Index: 19
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Background null Perineural invasion (PNI) has been associated with poor prognosis in oral squamous cell carcinoma (OSCC). Nerve growth factor (NGF) and its receptor tyrosine kinase A (TrkA) may play a role in PNI in OSCC. null null null Objective null To characterize the incidence and prognostic correlation of PNI in OSCC and to determine whether NGF and TrkA expressions could be used as biological markers for PNI in OSCC. null null null Methods null A retrospective review of pathology reports o...
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#1Ian R. Ellis (Dund.: University of Dundee)H-Index: 19
The link between the migration of cancer cells and the spread of cancers has been established for many years. Tumour invasion and metastasis was labelled as one of the original Hallmarks of Cancer in the seminal paper [...]
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#1Huda Alkhadar (Dund.: University of Dundee)H-Index: 2
#2Michaelina Macluskey (Dund.: University of Dundee)H-Index: 14
Last. Alexander Gardner (Dund.: University of Dundee)H-Index: 6
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Background/aim Machine learning analyses of cancer outcomes for oral cancer remain sparse compared to other types of cancer like breast or lung. The purpose of the present study was to compare the performance of machine learning algorithms in the prediction of global, recurrence-free five-year survival in oral cancer patients based on clinical and histopathological data. Methods Data was gathered retrospectively from 416 patients with oral squamous cell carcinoma. The dataset was divided into tr...
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#1Anem Iftikhar (Dund.: University of Dundee)H-Index: 1
#2Mohammad Islam (Dund.: University of Dundee)H-Index: 3
Last. Ian R. Ellis (Dund.: University of Dundee)H-Index: 19
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A single head and neck Cancer (HNC) is a globally growing challenge associated with significant morbidity and mortality. The diagnosis itself can affect the patients profoundly let alone the complex and disfiguring treatment. The highly important functions of structures of the head and neck such as mastication, speech, aesthetics, identity and social interactions make a cancer diagnosis in this region even more psychologically traumatic. The emotional distress engendered as a result of functiona...
1 CitationsSource
#1Huda Alkhadar (Dund.: University of Dundee)H-Index: 2
#2Michaelina Macluskey (Dund.: University of Dundee)H-Index: 14
Last. Ian R. Ellis (Dund.: University of Dundee)H-Index: 19
view all 4 authors...
BACKGROUND The objective of this study was to characterize the incidence and prognostic correlation of perineural invasion in oral squamous cell carcinoma and determine whether nerve growth factor and its receptor tyrosine Kinase A expression could be used as biological markers for perineural invasion. METHODS A retrospective review of pathology reports of 430 patients with oral squamous cell carcinoma who were treated from 1992 to 2014 in Tayside, Scotland was carried out. The expression of ner...
1 CitationsSource
#1Huda AlkhadarH-Index: 2
Last. Alexander GardnerH-Index: 6
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#1Hanan Ahmed (Dund.: University of Dundee)
#2Arpa Ghoshal (Dund.: University of Dundee)
Last. Mohammad Islam (Dund.: University of Dundee)H-Index: 3
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The signalling pathways involved in metastasis of oral adenoid cancer cells (TYS) in response to cancer-associated fibroblasts (COM D24) and normal oral mucosal fibroblasts (MM1) was examined. Metastatic cell behaviour was observed by cell-scatter, 3-D-collagen gel migration, and 3-D-spheroid invasion assays. Akt (v-Akt murine thymoma viral oncogene), MAPK(Mitogen activated protein kinase), EGFR (Epidermal growth factor receptor), TGFβRI (Transforming growth factor beta receptor 1), and CXCR4 (C...
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Last. Mohammad Tanvir IslamH-Index: 2
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#1Huda Alkhadar (Dund.: University of Dundee)H-Index: 2
#2Michaelina Macluskey (Dund.: University of Dundee)H-Index: 14
Last. Ian R. Ellis (Dund.: University of Dundee)H-Index: 19
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OBJECTIVES: The aims of this study were to investigate the role of nerve growth factor on perineural invasion in oral and salivary gland tumour cell lines and whether there is an involvement of PI3K/Akt pathway. MATERIALS AND METHODS: Four cell lines were investigated: HSG and TYS (salivary gland tumours), SAS-H1 (oral squamous cell carcinoma) and HaCaT (human skin keratinocyte). Initially, Boyden chamber assay was done to examine the effect of different concentration of nerve growth factor on c...
3 CitationsSource
#1Arwa AlghamdiH-Index: 1
#2Basher ShalgmH-Index: 1
Last. Sarah J. JonesH-Index: 9
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Introduction: TGF?1 activates both SMAD and non-SMAD dependent signalling pathways but their role in oral cancer cell migration and metastasis is little known. The aim of this research was to investigate the role of TGF?1-induced signalling pathways in oral cancer cell migration and to establish whether the inhibition of the associated pathway may be a suitable target for chemotherapeutic drug design to control oral cancer cell metastasis. Materials and Methods: SDS-PAGE and Western blot techniq...
1 CitationsSource