Jieshou Li
Nanjing University
Internal medicineEndocrinologySurgeryPathologyRetrospective cohort studyProspective cohort studyImmunologyFistulaAcute pancreatitisSepsisDiseaseCrohn's diseaseIn patientIntestinal mucosaAnesthesiaMedicineParenteral nutritionAnastomosisBiologyGastroenterology
624Publications
58H-index
9,219Citations
Publications 627
Newest
#1Kai Wang (NU: Nanjing University)H-Index: 60
BACKGROUND Fluid overload (FO) after resuscitation is frequent and contributes to adverse outcomes among postinjury open abdomen (OA) patients. Bioelectrical impedance analysis (BIA) is a promising tool for monitoring fluid status and FO. Therefore, we sought to investigate the efficacy of BIA-directed fluid resuscitation among OA patients. METHODS A pragmatic, prospective, randomized, observer-blind, single-center trial was performed for all trauma patients requiring OA between January 2013 and...
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#1Xinyu Wang (NU: Nanjing University)H-Index: 2
#2Shilong Sun (NU: Nanjing University)H-Index: 3
Last. Jieshou Li (NU: Nanjing University)H-Index: 58
view all 10 authors...
Abstract Background Sepsis impairs the function of the intestinal barrier through neutrophil extracellular traps (NETs). Reactive oxygen species (ROS)-induced activation of mitogen-activated protein kinase (MAPK) is involved in NET formation. Ethyl pyruvate (EP), a potent and effective ROS scavenger, ameliorates sepsis-associated intestinal barrier dysfunction, but the detailed mechanism is unknown. The current study aimed to explore the eff ;ects of EP on sepsis-induced intestinal barrier dysfun...
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#1Jianbo Yang (NU: Nanjing University)H-Index: 8
#2Haifeng Sun (NU: Nanjing University)H-Index: 4
Last. Xinying Wang (NU: Nanjing University)H-Index: 17
view all 11 authors...
Summary Background & Aims The long-term usage of parenteral nutrition (PN) is associated with the increased incidence of pneumonia. Few studies have focused on the pathogenesis of PN-associated lung injury (PNLI). Previous studies have found that autophagy suppression may be an important mechanism for PN-associated complications. The present study aimed to investigate the effect of PN on lung barrier impairment and its association with autophagy. Methods We retrospectively identified intestinal ...
1 CitationsSource
#1Jianfeng Tu (NU: Nanjing University)H-Index: 8
#2Jingzhu Zhang (NU: Nanjing University)H-Index: 4
Last. Jieshou Li (NU: Nanjing University)H-Index: 58
view all 8 authors...
The present study aimed to determine whether a difference in pancreatic function and quality of life (QoL) is present between patients with infected pancreatitis necrosis (IPN) undergoing open necrosectomy (ON) and minimally invasive drainage (MID). The medical records of patients with IPN discharged from Jinling Hospital were retrospectively analyzed. Pancreatic function and QoL were compared between patients treated with ON and MID. Pancreatic endocrine and exocrine function were assessed usin...
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#1Wei Cheng (Nanjing University of Chinese Medicine)H-Index: 28
#2Kai Wang (Xuzhou Medical College)H-Index: 4
Last. Jieshou Li (NU: Nanjing University)H-Index: 58
view all 10 authors...
Glucagon-like peptide-2 (GLP-2), a key factor in intestinal rehabilitation therapy of short bowel syndrome (SBS), may require cell-to-cell communication to exert its biological functions. However, understanding of the mechanism remains elusive. Here, we report participation of exosomal miR-125a/b in GLP-2 mediated intestinal epithelial cells-myofibroblasts cross-talk in intestinal microenvironment. Methods: The effects of GLP-2 on the proliferation and apoptosis of intestinal epithelial cells in...
1 CitationsSource
#1Shuang Zhen (NU: Nanjing University)
#2Cheng Zhao (SZU: Shenzhen University)H-Index: 5
Last. Jieshou Li (NU: Nanjing University)H-Index: 58
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Gut microbiota play an important role in many diseases. However, few researches evaluated the effect of faecal bacteria transplantation in protecting gut barrier during colitis. In this study, we focused on the effect of faecal microbiota encapsulated alginate microsphere on dextran sulfate sodium (DSS) induced colitis mice. Bacteria are sensitive to gastric juice and digestive enzymes, which is the dilemma of utilizing microbiota. Through taking advantage of alginate, microspheres that could pr...
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#1Na Pu (NU: Nanjing University)H-Index: 2
#2Qi Yang (NU: Nanjing University)H-Index: 6
Last. Jieshou Li (NU: Nanjing University)H-Index: 58
view all 14 authors...
Abstract Background The etiology of hypertriglyceridemia (HTG) and, consequently HTG-induced acute pancreatitis (HTG-AP), is complex. Objective Herein, we explore a possible gene-environment interaction between APOA5 c.553G>T (p.185Gly>Cys, rs2075291), a common variant associated with altered triglyceride levels, and pregnancy in HTG-AP. Methods We enrolled 318 Chinese HTG-AP patients and divided them into three distinct groups: group 1, male patients (n =183); group 2, female patients whose dis...
1 CitationsSource
#1Xiaoyao Li (NU: Nanjing University)H-Index: 4
#2Na Pu (NU: Nanjing University)H-Index: 2
Last. Jieshou Li (NU: Nanjing University)H-Index: 58
view all 14 authors...
BACKGROUND: Hypertriglyceridemia (HTG) is a leading cause of acute pancreatitis. HTG can be caused by either primary (genetic) or secondary etiological factors, and there is increasing appreciation of the interplay between the two kinds of factors in causing severe HTG. OBJECTIVES: The main aim of this study was to identify the genetic basis of hypertriglyceridemia-induced acute pancreatitis (HTG-AP) in a Chinese family with three affected members (the proband, his mother and older sister). METH...
2 CitationsSource
#1Guanwei LiH-Index: 13
#2Huajian Ren (NU: Nanjing University)H-Index: 13
Last. Jieshou Li (NU: Nanjing University)H-Index: 58
view all 9 authors...
Abstract Follistatin-like protein 1 (FSTL1) is a pleiotropic cytokine involved in multiple processes including organ development, carcinogenesis, metastasis and so on. Some recent studies have suggested a possible role of FSTL1 in the inflammatory diseases. We for the first time tried to unravel its effect on the colitis, and explore the possible mechanisms. Here we found that FSTL1 was upregulated in active human and murine colitis. It facilitated proinflammatory M1 polarization of macrophages ...
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#1Chengnan Chu (NU: Nanjing University)H-Index: 2
#2Chao Yang (NU: Nanjing University)H-Index: 1
Last. Jieshou Li (NU: Nanjing University)H-Index: 58
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Abstract Background Early intravenous administration of tranexamic acid has been shown to protect the intestinal barrier after a model of trauma-hemorrhagic shock in the rat, but the potential mechanism remains unclear. Our previous studies have demonstrated that neutrophil extracellular traps contribute to the intestinal barrier dysfunction during sepsis and other critical conditions. Meanwhile, there are high levels of neutrophil infiltration in the intestine during trauma-hemorrhagic shock. H...
2 CitationsSource