Oleg Kim
University of Pennsylvania
Ultimate tensile strengthOpticsBiophysicsInternal medicineShear flowBiomedical engineeringComposite materialContraction (grammar)CardiologyCompression (physics)Permeability (earth sciences)ChemistryViscoelasticityMaterials scienceIntegrinRheologyEmbolizationThrombinBlood vesselPeritoneal cavityHemostasisMetastasisMechanobiologyOvarian cancerThrombosisThrombusPlatelet activationCancer researchFibrinMechanicsMedicineBiologyPlatelet
72Publications
18H-index
898Citations
Publications 51
Newest
#1Karen P. Fong (UPenn: University of Pennsylvania)H-Index: 7
#2Ismail A. Ahmed (UPenn: University of Pennsylvania)H-Index: 7
Last. Joel S. Bennett (UPenn: University of Pennsylvania)H-Index: 62
view all 10 authors...
The fluorescent reporters commonly used to visualize proteins can perturb both protein structure and function. Recently, we found that 4-cyanotryptophan (4CN-Trp), a blue fluorescent amino acid, is suitable for one-photon imaging applications. Here, we demonstrate its utility in two-photon fluorescence microscopy by using it to image integrins on cell surfaces. Specifically, we used solid-phase peptide synthesis to generate CHAMP peptides labeled with 4-cyanoindole (4CNI) at their N-termini to i...
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#1Oleg Kim (UPenn: University of Pennsylvania)H-Index: 18
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#1Yuliya Klymenko (IU: Indiana University)H-Index: 8
#2Brandi Bos (ND: University of Notre Dame)H-Index: 1
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 8 authors...
Epithelial ovarian cancer (EOC) metastasis occurs by exfoliation of cells and multicellular aggregates (MCAs) from the tumor into the peritoneal cavity, adhesion to and retraction of peritoneal mesothelial cells and subsequent anchoring. Elevated levels of lysophosphatidic acid (LPA) have been linked to aberrant cell proliferation, oncogenesis, and metastasis. LPA disrupts junctional integrity and epithelial cohesion in vitro however, the fate of free-floating cells/MCAs and the response of host...
1 CitationsSource
#1Yuliya Klymenko (IU: Indiana University)H-Index: 8
#2Brandi Bos (ND: University of Notre Dame)H-Index: 1
Last. M. Sharon Stack (ND: University of Notre Dame)H-Index: 17
view all 8 authors...
Epithelial ovarian cancer (EOC) metastasis occurs by exfoliation of cells and multicellular aggregates (MCAs) from the tumor into the peritoneal cavity, adhesion to and retraction of peritoneal mesothelial cells and subsequent anchoring. Elevated levels of lysophosphatidic acid (LPA) have been linked to aberrant cell proliferation, oncogenesis, and metastasis. LPA disrupts junctional integrity and epithelial cohesion in vitro however, the fate of free-floating cells/MCAs and the response of host...
#1Oleg Kim (UCR: University of California, Riverside)H-Index: 18
#2Tatiana A. Nevzorova (Kazan: Kazan Federal University)H-Index: 4
Last. John W. Weisel (UPenn: University of Pennsylvania)H-Index: 81
view all 12 authors...
Platelets play a key role in formation of hemostatic clots and obstructive thrombi as well as in other biological processes. In response to physiological stimulants, including thrombin, platelets change their morphology, express adhesive molecules, undergo aggregation, and secrete bioactive substances, but their subsequent fate is largely unknown. Here we examine late-stage structural, metabolic, and functional consequences of thrombin-induced platelet activation. Using a combination of confocal...
11 CitationsSource
#1Samuel Britton (UCR: University of California, Riverside)H-Index: 1
#2Oleg Kim (UPenn: University of Pennsylvania)H-Index: 18
Last. Mark Alber (UCR: University of California, Riverside)H-Index: 41
view all 7 authors...
Abstract Fibrin is a viscoelastic proteinaceous polymer that determines the deformability and integrity of blood clots and fibrin-based biomaterials in response to biomechanical forces. Here, a previously unnoticed structural mechanism of fibrin clots' mechanical response to external tensile loads is tested using high-resolution confocal microscopy and recently developed three-dimensional computational model. This mechanism, underlying local strain-stiffening of individual fibers as well as glob...
6 CitationsSource
#1Mark AlberH-Index: 41
#2Shixin XuH-Index: 8
Last. John W. WeiselH-Index: 81
view all 7 authors...
1 CitationsSource
#1Oleg KimH-Index: 18
#2Rustem I. LitvinovH-Index: 37
Last. John W. WeiselH-Index: 81
view all 4 authors...
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#1Rustem I. Litvinov (Kazan: Kazan Federal University)H-Index: 37
#2Karen Pei Yi Fong (UPenn: University of Pennsylvania)
Last. Joel S. Bennett (UPenn: University of Pennsylvania)H-Index: 62
view all 10 authors...
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#1Oleg Kim (UPenn: University of Pennsylvania)H-Index: 18
#2Tatiana A. Nevzorova (Kazan: Kazan Federal University)H-Index: 4
Last. John W. Weisel (UPenn: University of Pennsylvania)H-Index: 81
view all 9 authors...
Introduction: Platelets play a key role in formation of protective hemostatic blood clots and pathological obstructive thrombi. Under (patho)physiological conditions, chemically activated platelets change their morphology, express adhesive molecules, undergo aggregation, secrete procoagulant substances, and induce mechanical contraction (retraction) of the blood clots. Despite the vital importance of these platelet functions, the subsequent fate of activated platelets is largely unknown. We hypo...
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