Ronald Klein
University of Wisconsin-Madison
OphthalmologyOptometryInternal medicineEndocrinologySurgeryOdds ratioCardiologyCohort studyEye diseaseMacular degenerationRetinopathyDiabetic retinopathyRetinalPopulationIncidence (epidemiology)Risk factorDiabetes mellitusMedicineBlood pressureBiology
Publications 1503
#1Josyf C. Mychaleckyj (UVA: University of Virginia)H-Index: 37
#2Erkka ValoH-Index: 10
Last. Suna Onengut-Gumuscu (UVA: University of Virginia)H-Index: 29
view all 36 authors...
Background null Rare variants in gene coding regions likely have a greater impact on disease-related phenotypes than common variants through disruption of their encoded protein. We searched for rare variants associated with onset of end stage kidney disease (ESKD) in individuals with type 1 diabetes at advanced kidney disease stage. null Methods null Gene-based exome array analysis of 15,449 genes in 5 large incidence cohorts of individuals with type 1 diabetes and proteinuria were analyzed for ...
#1Joseph G. Timmons (Glas.: University of Glasgow)H-Index: 2
#1JG Timmons (Glas.: University of Glasgow)
Last. John R. Petrie (Glas.: University of Glasgow)H-Index: 58
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Aim To determine whether metformin's effects on carotid artery intima-media thickness (cIMT) in type 1 diabetes differ according to smoking status. Methods Regression model effect estimates for the effect of metformin versus placebo (double-blind) on carotid IMT were calculated as a subgroup analysis of the REMOVAL trial. Results In 428 randomized participants (227 never-smokers, 201 ever-smokers), averaged mean carotid IMT progression (per year) was reduced by metformin versus placebo in never-...
#2Ronald KleinH-Index: 215
#1Bahram Khazai (UM: University of Miami)H-Index: 4
#2Fatemeh Adabifirouzjaei (UCSD: University of California, San Diego)
Last. Matthew J. Budoff (Los Angeles Biomedical Research Institute)H-Index: 138
view all 15 authors...
Retinopathy is a microvascular complication of diabetes mellitus (DM); however, it is also increasingly recognized in persons without DM. The microvascular diseases may play a prominent role in coronary heart disease (CHD) development in individuals with DM. We performed the study to evaluate the relation between non-DM retinopathy and CHD and also the association between baseline retinopathy and incidence and progression of CHD in individuals with and without DM. We included 5709 subjects with ...
#1Michael P. Bancks (Wake Forest University)H-Index: 13
#2Mercedes R. Carnethon (NU: Northwestern University)H-Index: 77
Last. Alain G. Bertoni (Wake Forest University)H-Index: 78
view all 8 authors...
Abstract Aims To characterize diabetes subgroups among a multi-ethnic cohort and assess risk for incident complications. Methods We included 1587 participants from the Multi-Ethnic Study of Atherosclerosis with diabetes. We characterized eight diabetes subgroups according to absolute thresholds for disease characteristics: age at diabetes diagnosis (≤45 years), fasting glucose (FG ≥7.7 mmol/L; ≥140 mg/dL), and waist circumference (women ≥105 cm; men ≥110 cm). We estimated risk for mortality, inc...
#1Ning Cheung (NUS: National University of Singapore)H-Index: 8
#2Miao Li CheeH-Index: 11
Last. Tien Yin Wong (NUS: National University of Singapore)H-Index: 178
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Aim To provide contemporary longitudinal data on the incidence and progression of diabetic retinopathy (DR) in a multi-ethnic population of whites, African Americans, Chinese and Hispanics in the United States. Methods A prospective, multi-region, multi-ethnic population-based cohort study that included 498 participants with diabetes, aged 45–84 years at baseline, from the Multi-Ethnic Study of Atherosclerosis with retinal images obtained twice, on average 8 years apart. Presence and severity of...
#1Adam J. Paulsen (UW: University of Wisconsin-Madison)H-Index: 6
#2Alex Pinto (UW: University of Wisconsin-Madison)H-Index: 10
Last. Karen J. Cruickshanks (UW: University of Wisconsin-Madison)H-Index: 85
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To determine if incidence of contrast sensitivity (CS) impairment differs by generation and identify factors to explain these differences. The Beaver Dam Eye Study (BDES) and Beaver Dam Offspring S...
#1Weng Kit LyeH-Index: 11
#2Euan N Paterson ('QUB': Queen's University Belfast)H-Index: 3
Last. Gareth J. McKay ('QUB': Queen's University Belfast)H-Index: 26
view all 23 authors...
Previously, variation in retinal vascular caliber has been reported in association with chronic kidney disease (CKD) but findings remain inconsistent. To help clarify this we conducted individual participant data meta-analysis and aggregate data meta-analysis on summary estimates to evaluate cross-sectional associations between retinal vascular caliber and CKD. A systematic review was performed using Medline and EMBASE for articles published until October 2018. The aggregate analysis used a two-...
1 CitationsSource
#1Shruti Dighe (SUNY: State University of New York System)H-Index: 1
#2Jiwei Zhao (SUNY: State University of New York System)H-Index: 11
Last. Amy E. Millen (SUNY: State University of New York System)H-Index: 35
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Background Age-related macular degeneration (AMD) is the leading cause of irreversible vision loss among the elderly. Objective This study aimed to determine the association between dietary patterns and food groups (used to make them) with the 18-year incidence of AMD. Methods ARIC (Atherosclerosis Risk in Communities) participants who showed change in AMD lesions between retinal photographs taken at visit 3 and visit 5 were graded side by side to determine incident AMD (any=144; early=117; late...
3 CitationsSource