Andrew G. Nicholson
National Institutes of Health
CancerInternal medicineRadiologySurgeryPathologyOncologyImmunologyImmunohistochemistryBiopsyRespiratory diseaseLung cancerInterstitial lung diseaseCarcinomaLungIdiopathic pulmonary fibrosisAdenocarcinomaPulmonary fibrosisCancer researchMedicineBiology
Publications 485
#8Shir Kiong Lu (NIH: National Institutes of Health)H-Index: 1
Lung cancer is the most frequent cause of cancer death worldwide. It affects more men than women, and men generally have worse survival outcomes. We compared gene co-expression networks in affected and unaffected lung tissue from 126 consecutive patients with Stage IA-IV lung cancer undergoing surgery with curative intent. We observed marked degradation of a sex-associated transcription network in tumour tissue. This disturbance, detected in 27.7% of male tumours in the discovery dataset and 27....
#1Yu Zhi Zhang (NIH: National Institutes of Health)H-Index: 2
#2Cecilia Brambilla (NIH: National Institutes of Health)H-Index: 2
Last. Andrew G. Nicholson (NIH: National Institutes of Health)H-Index: 123
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Abstract null Significant progress in the diagnosis and classification of pleural mesothelioma has been made in the past 5 years. Novel biomarkers are now entering more widespread use following major advances in understanding the genomic landscape of the malignancy. As the diagnosis and management of mesothelioma becomes more multidisciplinary together with the increasing role of histopathology in providing additional prognostic information to guide downstream management, we review herein newly ...
#1Jefree J. Schulte (U of C: University of Chicago)H-Index: 6
#2David B. Chapel (U of C: University of Chicago)H-Index: 10
Last. Aliya N. Husain (U of C: University of Chicago)H-Index: 46
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OBJECTIVES Numerous studies on malignant mesothelioma (MM) highlight the prognostic importance of histologic subtype, nuclear grade, and necrosis. This study compares these parameters in paired biopsy and resection specimens of pleural MM. METHODS Histologic subtype, percentage of epithelioid morphology, nuclear grade, and the presence or absence of necrosis were compared in 429 paired biopsies and resection specimens of pleural MM from 19 institutions. RESULTS Histologic subtype was concordant ...
2 CitationsSource
#1A. Nastase (Imperial College London)H-Index: 1
#2A. Mandal (Imperial College London)H-Index: 9
Last. William O.C.M. Cookson (Imperial College London)H-Index: 91
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Abstract Background Malignant pleural mesothelioma (MPM) is an aggressive malignancy with limited effective therapies. Methods In order to identify therapeutic targets, we integrated SNP genotyping, sequencing and transcriptomics from tumours and low-passage patient-derived cells. Results Previously unrecognised losses of SUFU locus (10q24.32), observed in 21% of 118 tumours, resulted in disordered expression of transcripts from Hedgehog pathways and the T-cell synapse including VISTA. Co-deleti...
1 CitationsSource
#1Mari Mino-Kenudson (Harvard University)H-Index: 93
#2Nolwenn Le StangH-Index: 12
Last. Sylvie Lantuejoul (UGA: University of Grenoble)H-Index: 65
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Abstract Background PD-L1 immunohistochemistry (IHC) is required to determine eligibility for pembrolizumab monotherapy in advanced non-small cell lung cancer (NSCLC) worldwide and for several other indications depending on the country. Four assays have been approved/CE-IVD marked, but PD-L1 IHC seems diversely implemented across regions and laboratories with the application of laboratory-developed tests (LDTs). Method To assess practice of PD-L1 IHC and identify issues and disparities, the IASL...
#1Peter M. OdorH-Index: 10
#2S. BampoeH-Index: 11
Last. A. WickhamH-Index: 1
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There are no current descriptions of general anaesthesia characteristics for obstetric surgery, despite recent changes to patient baseline characteristics and airway management guidelines. This analysis of data from the direct reporting of awareness in maternity patients' (DREAMY) study of accidental awareness during obstetric anaesthesia aimed to describe practice for obstetric general anaesthesia in England and compare with earlier surveys and best-practice recommendations. Consenting patients...
10 CitationsSource
#1Sonja Klebe (Flinders University)H-Index: 32
#2Yukio Nakatani (Chiba University)H-Index: 40
Last. Anders Hjerpe (Karolinska University Hospital)H-Index: 53
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Diffuse malignant mesothelioma (MM) is an incurable tumour of the serosal membranes, which is often caused by exposure to asbestos and commonly diagnosed at advanced stage. Malignant mesothelioma in situ (MMIS) is now included as diagnostic category by the World Health Organization (WHO). However, our international survey of 34 pulmonary pathologists with an interest in MM diagnosis highlights inconsistency regarding how the diagnosis is being made by experts, despite published guidelines. Whils...
#1Rebecca Devaney (NUH: Nottingham University Hospitals NHS Trust)H-Index: 1
#2Timothy Simpson (University of Nottingham)
Last. Jayesh M. Bhatt (NUH: Nottingham University Hospitals NHS Trust)H-Index: 13
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#1Salma Abdelhady (Ain Shams University)
#2E M Fouda (Ain Shams University)H-Index: 5
Last. Heba M. Hamza (Ain Shams University)
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Background Childhood interstitial and diffuse lung diseases (chILD) encompass a broad spectrum of rare pulmonary disorders. In most developing middle eastern countries, chILD is still underdiagnosed. Objective: To describe and investigate patients diagnosed with chILD in a tertiary university hospital in Egypt. Methods We analyzed data of consecutive subjects ( Results 22 subjects were enrolled over 24 months. Median age at diagnosis was 7 years (range 3.5–14 years). The most common manifestatio...