Tanja Schlereth
University of Mainz
PathophysiologyEndocrinologyNociceptionPsychologyCalcitonin gene-related peptideNeuroscienceChemistryImmunologyAcetylcholineNeurogenic inflammationSympathetic nervous systemSubstance PInflammationAllodyniaSudomotorComplex regional pain syndromeSpinal cordAnesthesiaMicrodialysisMedicine
56Publications
22H-index
1,524Citations
Publications 55
Newest
Diabetic neuropathy (dNP) patients often suffer from severe neuropathic pain. It was suggested that alpha-1 adrenoceptor (α1-AR) hyperresponsiveness contributes to pain in dNP. The aim of our study was to quantify α1-AR expression using immunohistochemistry in skin biopsies of nine patients with painful diabetic neuropathy compared to 10 healthy controls. Additionally, the association between α1-AR expression and activation with spontaneous and sympathetically maintained pain (SMP) induced by in...
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ABSTRACT Matrix metalloproteinases (MMP)-2 and MMP-9 play important roles in inflammation as well as in pain processes. For this reason, we compared the concentrations of these enzymes in skin and serum of patients with complex regional pain syndrome (CRPS), other pain diseases and healthy subjects. We analyzed ipsi- and contralateral skin biopsies of 18 CRPS patients, as well as in 10 pain controls and 9 healthy subjects. Serum samples were analyzed from 20 CRPS, 17 pain controls and 17 healthy...
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#1Simone König (WWU: University of Münster)H-Index: 23
#2Malte Bayer (WWU: University of Münster)H-Index: 5
Last. Frank Birklein (University of Mainz)H-Index: 67
view all 10 authors...
: Complex regional pain syndrome (CRPS) develops after fracture. The acute CRPS phenotype resembles exaggerated inflammation, which is explained by local and systemic activation of a proinflammatory network including peptides and cytokines. Epidemiologic data suggest that inactivation of the peptidase angiotensin-converting enzyme in patients treated for hypertension increases the odds to develop CRPS. This hint leads us to investigate the serum protease network activity in patients with CRPS vs...
5 CitationsSource
#1Frank Birklein (University of Mainz)H-Index: 67
#2Alaa Ibrahim (University of Mainz)H-Index: 2
Last. Wade S. KingeryH-Index: 47
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Abstract Distal limb fracture is the most common cause of complex regional pain syndrome (CRPS), thus the rodent tibia fracture model (TFM) was developed to study CRPS pathogenesis. This comprehensive review summarizes the published TFM research and compares these experimental results with the CRPS literature. The TFM generated spontaneous and evoked pain behaviors, inflammatory symptoms (edema, warmth), and trophic changes (skin thickening, osteoporosis) resembling symptoms in early CRPS. Neuro...
16 CitationsSource
#1Matthias Wittayer (University of Mainz)H-Index: 1
#2Violeta Dimova (University of Mainz)H-Index: 3
Last. Tanja Schlereth (University of Mainz)H-Index: 22
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: Neglect-like symptoms (NLS) are frequently observed in complex regional pain syndrome (CRPS). The clinical meaning of NLS, however, is largely unknown. Therefore, this study sets out to assess the importance of NLS for patient outcome and to explore their clinical correlates. We assessed NLS in a group of 53 patients with CRPS and compared the results to 28 healthy volunteers. To define the origin of the NLS reports, we tested the subjective visual midline, performed a limb-laterality recognit...
18 CitationsSource
#1Wen-Wu Li (Stanford University)H-Index: 32
#2Tian-Zhi GuoH-Index: 28
Last. J. David Clark (Stanford University)H-Index: 53
view all 7 authors...
Both dysfunctional neuropeptide signaling and immune system activation are characteristic of complex regional pain syndrome (CRPS). Unknown is whether substance P (SP) or calcitonin gene-related peptide (CGRP) support autoantibody production and, consequently, nociceptive sensitization. These experiments involved the use of a well-characterized tibia fracture model of CRPS. Mice deficient in SP expression (Tac1−/−) and CGRP signaling (RAMP1−/−) were used to probe the neuropeptide dependence of p...
14 CitationsSource
#1Alison Llewellyn (United Hospitals)H-Index: 5
#2Candy McCabe (United Hospitals)H-Index: 21
Last. P Moskovitz (George Washington University Hospital)H-Index: 1
view all 23 authors...
Background: Complex Regional Pain Syndrome (CRPS) symptoms can significantly differ between patients, fluctuate over time, disappear or persist. This leads to problems in defining recovery and in evaluating the efficacy of therapeutic interventions. Objectives: To define recovery from the patients’ perspective and better understand their priorities for treatment approaches. Methods: Establishing an international consortium, we used a 2-Round Delphi-based study in eight countries across Europe an...
13 CitationsSource
Ziel dieser Studie war der Vergleich der Zufriedenheit und des Behandlungserfolgs bei Schmerzpatienten, die interdisziplinar (anasthesiologisch, psychosomatisch, neurologisch, orthopadisch) oder rein neurologisch betreut wurden. Methoden Es wurden 183 Patienten ausgewahlt, die in unserer neurologischen Ambulanz und in unserem interdisziplinaren Schmerztherapiezentrum (IST) behandelt wurden. Davon wurden 142 Patienten mit Polyneuropathie, Kopfschmerz oder muskuloskelettalen Schmerzen in die endgu...
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#1Simone König (WWU: University of Münster)H-Index: 23
#2Tanja SchlerethH-Index: 22
Last. Frank BirkleinH-Index: 67
view all 3 authors...
ABSTRACTIntroduction: Complex Regional Pain Syndrome (CRPS) is a rare, but often disabling pain disease. Biomarkers are lacking, but several inflammatory substances have been associated with the pathophysiology. This review outlines the current knowledge with respect to target biomolecules and the analytical tools available to measure them.Areas covered: Targets include cytokines, neuropeptides and resolvins; analysis strategies are thus needed for different classes of substances such as protein...
8 CitationsSource
#1R. Norman Harden (LUMC: Leiden University Medical Center)H-Index: 37
#2Christian Maihöfner (FAU: University of Erlangen-Nuremberg)H-Index: 53
Last. Stephen Bruehl (Vandy: Vanderbilt University)H-Index: 56
view all 22 authors...
Clinical diagnosis of complex regional pain syndrome (CRPS) is a dichotomous (yes/no) categorization, a format necessary for clinical decision making. Such dichotomous diagnostic categories do not convey an individual's subtle gradations in the severity of the condition over time and have poor statistical power when used as an outcome measure in research. This prospective, international, multicenter study slightly modified and further evaluated the validity of the CRPS Severity Score (CSS), a co...
32 CitationsSource