Jingguo Li
Zhengzhou University
MicelleBiophysicsMolecular biologyNanocarriersChemistryApoptosisMaterials scienceIn vitroIn vivoSmall interfering RNARetinoblastomaCelastrolDrug deliveryTissue engineeringCancer researchTransfectionScaffoldNanofiberCancer cellPharmacology
49Publications
17H-index
917Citations
Publications 45
Newest
#1Zhanrong Li (Zhengzhou University)H-Index: 7
#2Xingcai Zhang (MIT: Massachusetts Institute of Technology)H-Index: 23
Last. Jingguo Li (Zhengzhou University)H-Index: 17
view all 12 authors...
Abstract Effective osteogenesis remains a challenge in the treatment of bone defects. The emergence of artificial bone scaffolds provides an attractive solution. In this work, a new biomineralization strategy is proposed to facilitate osteogenesis through sustaining supply of nutrients including phosphorus (P), calcium (Ca), and silicon (Si). We developed black phosphorus (BP)-based, three-dimensional nanocomposite fibrous scaffolds via microfluidic technology to provide a wealth of essential io...
1 CitationsSource
#1Liuqi Shi (Zhengzhou University)H-Index: 2
#2Huayang Feng (Zhengzhou University)H-Index: 4
Last. Jingguo Li (Zhengzhou University)H-Index: 17
view all 6 authors...
Due to the complex physiological characteristics of tumors, chemotherapy or gene therapy alone cannot completely kill tumor cells. Therefore, combining chemotherapy with gene therapy for combination therapy is the key to solving this problem. However, there are still significant challenges in how to simultaneously deliver and rapidly release the drugs and siRNA into cancer cells. In this work, a triblock copolymer was synthesized to co-deliver siRNA and paclitaxel to tumor cells. This system has...
Source
#1Fan YangH-Index: 1
#2Zhihua GuoH-Index: 3
Last. Jingguo LiH-Index: 17
view all 7 authors...
Retinoblastoma (RB) makes up about 3% of all childhood malignancies. Chemotherapy is commonly applied for RB treatment, while the clinical effectiveness varies significantly due to the cancer therapeutic resistances. Hypoxic tumor microenvironment, a hallmark of all tumors, is strongly associated with malignant progress and therapeutic resistances. The hypoxia mainly promotes the angiogenesis by upregulating pro-angiogenetic pathways. In this work, polymeric micelles are used as the carrier to d...
Source
#1Lemei AnH-Index: 1
#2Zhanrong Li (Zhengzhou University)H-Index: 7
Last. Jingguo Li (Zhengzhou University)H-Index: 17
view all 8 authors...
Rheumatoid arthritis (RA) is a systemic inflammatory disorder which can cause bone and cartilage damage leading to disability, yet the treatment remains unsatisfactory nowadays. Celastrol (Cel) has...
3 CitationsSource
#1Huayang FengH-Index: 4
#2Dandan ChuH-Index: 4
Last. Jingguo Li (Zhengzhou University)H-Index: 17
view all 7 authors...
1 CitationsSource
#1Zhihua Guo (Zhengzhou University)H-Index: 3
#2Liuqi Shi (Zhengzhou University)H-Index: 2
Last. Jingguo Li (Zhengzhou University)H-Index: 17
view all 8 authors...
Abstract Celastrol, a Chinese herbal medicine, has exhibited anticancer activity in many types of cancer cells. However, the further clinical application of celastrol is restricted by its poor water solubility and serious side effects. Furthermore, the apoptosis mechanism of tumor cells induced by celastrol has not been exhausted yet. In this study, we developed a reduction sensitive polymeric vector for tumor-targeted celastrol delivery. And our researches indicated that the celastrol could be ...
3 CitationsSource
#1Zhengqi Dong (Peking Union Medical College)H-Index: 3
#2Xiangtao Wang (Peking Union Medical College)H-Index: 12
Last. Yifei Guo (Peking Union Medical College)H-Index: 14
view all 9 authors...
To study the structural influence, hybrid amphiphilic copolymer (G2C18) and linear amphiphilic copolymer (PEG45C18) were utilized to prepare docetaxel (DTX)-loaded nanoparticles through an antisolvent precipitation method. The different architectures of the hydrophilic portion affected the particle sizes significantly, and then induced the different antitumor activity. Compared with DTX/PEG45C18 nanoparticles, the antitumor efficacy of DTX/G2C18 nanoparticles was significantly enhanced, the IC50...
1 CitationsSource
#1Zhanrong Li (Zhengzhou University)H-Index: 7
#2Zhihua Guo (Zhengzhou University)H-Index: 3
Last. Jingguo Li (Zhengzhou University)H-Index: 17
view all 7 authors...
Celastrol, a Chinese herbal medicine, has already shown an inhibition effect on retinoblastoma growth activity in our previous research, but its mechanism is not well understood. Angiogenes...
6 CitationsSource
#1Fengqi Han (Zhengzhou University)H-Index: 3
#2Shupei Lv (Zhengzhou University)H-Index: 1
Last. Jingguo Li (Zhengzhou University)H-Index: 17
view all 10 authors...
Two-dimensional (2D) nanomaterials have raised significant interest in not only energy and environmental fields but also biomedical areas. Among these materials, one type that has many interesting properties and possesses numerous exciting applications is graphene oxide (GO)-based 2D materials. However, their poor stability in aqueous solutions and weak bioactivities limit their use in biomedical applications, especially antimicrobial fields. In this study, GO was functionalized with hydrophilic...
11 CitationsSource
#1Yan Zheng (Zhengzhou University)H-Index: 1
#2Zhan-Rong LiH-Index: 1
Last. Shuangyin Han (Zhengzhou University)H-Index: 3
view all 8 authors...
CAR-T cell-based immunotherapy has shown great promise in clinical trials for the treatment of hematological malignancies. The majority of these trials utilize retroviral and lentiviral vectors to introduce CAR transgene. In spite of its satisfactory efficiency, the concerns about the potential carcinogenicity and complicated synthesis procedure restrict widespread clinical applications of viral vectors. Recent studies show that transposon-based gene transfer is a safer and simpler non-viral app...
5 Citations