Ling-Yi Kong
China Pharmaceutical University
CytotoxicityCircular dichroismOrganic chemistryChemistryApoptosisGlycosideTwo-dimensional nuclear magnetic resonance spectroscopyIn vitroAbsolute configurationMoietyIC50Ring (chemistry)Ic50 valuesChromatographyCancer researchBiochemistryStereochemistryMedicineBiologyPharmacology
692Publications
58H-index
9,667Citations
Publications 665
Newest
#1Li LiH-Index: 2
#2Shan LiH-Index: 1
Last. Jun LuoH-Index: 22
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#1Yunpeng Sun (CPU: China Pharmaceutical University)
#2Letian Cui (CPU: China Pharmaceutical University)H-Index: 1
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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Abstract null null Mufolinin A (1), a ring A-seco rearranged limonoid with an unprecedented ethyl at C-10 and novel 6/6/6/5 fused-ring skeleton, together with three new potential precursors (ring A-seco limonoids, 2–4) were isolated from Munronia unifoliolata. Their structures and absolute configurations were confirmed by nuclear magnetic resonance (NMR), high resolution electrospray ionization mass spectroscopy (HRESIMS), X-ray crystallography, electronic circular dichroism (ECD) calculations a...
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#1Chen Chen (CPU: China Pharmaceutical University)H-Index: 6
#2Tianyu Zhu (CPU: China Pharmaceutical University)H-Index: 5
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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Abstract null null The first rate-limiting enzyme of the serine synthesis pathway (SSP), phosphoglycerate dehydrogenase (PHGDH), is hyperactive in multiple tumors, which leads to the activation of SSP and promotes tumorigenesis. However, only a few inhibitors of PHGDH have been discovered to date, especially the covalent inhibitors of PHGDH. Here, we identified withangulatin A (WA), a natural small molecule, as a novel covalent inhibitor of PHGDH. Affinity-based protein profiling identified that...
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#1Chen Chen (CPU: China Pharmaceutical University)H-Index: 6
#2Xiao-Qin Liu (CPU: China Pharmaceutical University)H-Index: 2
Last. Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 28
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Abstract null null Increasing evidence have reported that NLRP3 inflammasome has a crucial role in various kinds of immunological diseases including colitis. However, there have only a few drug candidates directly targeting inflammasomes for the therapy of colitis. Here, we first reported that Tubocapsanolide A (TA), a natural small molecule, as a novel inhibitor of NLRP3 inflammasome for the treatment of colitis. TA inhibited the activation of NLRP3 inflammasome and suppressed the secretion of ...
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#1Dong-Rong Zhu (CPU: China Pharmaceutical University)H-Index: 5
#2Chen Chen (CPU: China Pharmaceutical University)H-Index: 6
Last. Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 28
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Abstract null null Introduction null Previously, we have reported a withanolide-type steroid, named tubocapsenolide A (TA), which shows potent anti-proliferative activity in several cancer cell lines. However, its inhibitory effect on the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathway and therapeutic potential on osteosarcoma have not been reported. null null null Objectives null In the present study, we aimed to investigate the effect and molecular mechanism...
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#1Hua-Rong Zhao (CPU: China Pharmaceutical University)
#2Xiao-Qin Liu (CPU: China Pharmaceutical University)H-Index: 2
Last. Jian-Guang Luo (CPU: China Pharmaceutical University)H-Index: 28
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Abstract Four new highly oxidized sesquiterpene lactones, Argyoxynolides A–D, along with two known analogs were isolated from the leaves of Artemisia argyi H.Lev. & Vaniot. Their structures were characterized utilizing extensive spectroscopic methods. All isolates were evaluated for the LPS-induced nitric oxide (NO) production inhibitory activity and one compound exhibited activity with IC50 = 37.95 ± 4.39 μM.
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#1Yuhao Ren (CPU: China Pharmaceutical University)H-Index: 3
#2Shanshan Li (CPU: China Pharmaceutical University)H-Index: 44
Last. Wenying Yu (CPU: China Pharmaceutical University)H-Index: 15
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Nowadays, simultaneous inhibition of multiple targets through drug combination is an important anticancer strategy owing to the complex mechanism behind tumorigenesis. Recent studies have demonstrated that the inhibition of histone deacetylases (HDACs) will lead to compensated activation of a notorious cancer-related drug target, signal transducer and activator of transcription 3 (STAT3), in breast cancer through a cascade, which probably limits the anti-proliferation effect of HDAC inhibitors i...
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#1Yun-Ge Bu (CPU: China Pharmaceutical University)H-Index: 1
#2Wen-Yan Zhang (CPU: China Pharmaceutical University)H-Index: 2
Last. Ling-Yi Kong (CPU: China Pharmaceutical University)H-Index: 58
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A new andirobin-type limonoid with modified furan ring, khaysenelide K (1), together with a known analogue (2), was isolated from the stem barks of Khaya senegalensis. The structure and absolute co...
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#1Zhirong Cui (CPU: China Pharmaceutical University)H-Index: 3
#2Yi Li (Nanjing Normal University)H-Index: 4
Last. Jun Luo (CPU: China Pharmaceutical University)H-Index: 22
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INTRODUCTION Melia toosendan Sieb. et Zucc. has been used as a Chinese folk medicine for roundworm treatment since ancient times. Many diverse limonoids have been isolated from Meliaceae plants, but it remains difficult to isolate and identify other limonoids because of their small natural concentrations. OBJECTIVE This study was performed to overcome the difficulties associated with fast and accurate identification of limonoids and establish a reliable and sensitive method for the analysis of m...
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