Jose Luis Calleja
Autonomous University of Madrid
Internal medicineSurgeryViral loadVirologyRandomized controlled trialAdverse effectImmunologyHepatitis C virusHepatitis CLiver diseaseCirrhosisHepatocellular carcinomaSofosbuvirPortal hypertensionLiver transplantationRibavirinPopulationPortal venous pressureMedicineGastroenterology
194Publications
40H-index
5,901Citations
Publications 191
Newest
#1Juan TurnesH-Index: 21
#2Diego Rincón (Hospital General Universitario Gregorio Marañón)H-Index: 26
Last. Marta CalvoH-Index: 24
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BACKGROUND AND OBJECTIVE The emergence of highly tolerable, effective, and shorter duration direct-acting antivirals (DAAs) regimens offers the opportunity to simplify hepatitis C virus management but medical costs are unknown. Thus, we aimed to determine the direct medical costs associated with a combo-simplified strategy (one-step diagnosis and low monitoring) to manage HCV infection within an 8-week glecaprevir/pibrentasvir (GLE/PIB) regimen in clinical practice in Spain. PATIENTS AND METHODS...
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BACKGROUND AND AIMS Transient elastography (TE) to estimate liver stiffness has proved to be very useful in the diagnosis of chronic liver disease. Here, we intend to evaluate its use in a large Spanish cohort. METHOD Nested study within the PREVHEP-ETHON (Epidemiological sTudy of Hepatic infectiONs; NCT02749864) population-based, cross-sectional study performed between July 2015 and April 2017. An epidemiological questionnaire, laboratory tests and TE and anthropometric measurements were obtain...
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#1Marta Hernández-Conde (ISCIII: Carlos III Health Institute)H-Index: 3
#2Elba Llop (ISCIII: Carlos III Health Institute)H-Index: 18
Last. Jose Luis CallejaH-Index: 40
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INTRODUCTION The effect of branched-chain amino acid (BCAA) supplementation on muscle mass in patients with cirrhosis and sarcopenia is unknown. METHODS This is a pilot, prospective, randomized, and double-blind study of a cohort of 32 patients with cirrhosis and sarcopenia diagnosed by computed tomography scan who underwent a nutritional and physical activity intervention for 12 weeks. They were divided into 2 groups (placebo: 17 patients; BCAA: 15 patients). The study protocol was registered a...
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#1Càndid Villanueva (Autonomous University of Barcelona)H-Index: 33
#2Agustín Albillos (University of Alcalá)H-Index: 55
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ABSTRACT BACKGROUND & AIMS Prognosis of compensated cirrhosis is good until decompensation. In decompensated cirrhosis, bacterial infections (BIs) are common and increase the risk of death. The incidence and prognostic implications of BIs in compensated cirrhosis are less characterized. This study aimed to assess whether BIs influence the risk of decompensation and survival in patients with compensated cirrhosis. METHODS This is a cohort study nested to the PREDESCI, a double-blind, multicenter ...
1 CitationsSource
#1George V. Papatheodoridis (UoA: National and Kapodistrian University of Athens)H-Index: 78
#2George N. DalekosH-Index: 31
Last. Pietro Lampertico (University of Milan)H-Index: 58
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ABSTRACT Background & Aims Recently, several risk scores for prediction of hepatocellular carcinoma (HCC) were developed in cohorts of treated Asian patients with chronic hepatitis B (CHB), but they have not been assessed in non-Asian patients. We evaluated the predictability and comparative utility of our PAGE-B and recent Asian HCC risk scores in nucleos(t)ide analogue (NA) treated adult Caucasian CHB patients, with or without well documented compensated cirrhosis but not previous diagnosis of...
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#1Javier Martínez (University of Alcalá)H-Index: 30
#2Virginia Hernández-Gea (University of Barcelona)H-Index: 27
Last. Baveno CooperationH-Index: 1
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BACKGROUND AND AIMS Antibiotic prophylaxis reduces the risk of infection and mortality in cirrhotic patients with acute variceal bleeding (AVB). This study examines the incidence and risk factors of bacterial infections during hospitalization in patients with AVB on antibiotic prophylaxis. METHODS Post-hoc analysis of the database of an international, multicenter, observational study designed to examine the role of preemptive TIPS in patients with cirrhosis and AVB. Data collected on patients wi...
1 CitationsSource
#1Victor Sapena (University of Barcelona)H-Index: 4
#2Marco Enea (University of Palermo)H-Index: 17
Last. Maria Reig (University of Barcelona)H-Index: 33
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OBJECTIVE The benefit of direct-acting antivirals (DAAs) against HCV following successful treatment of hepatocellular carcinoma (HCC) remains controversial. This meta-analysis of individual patient data assessed HCC recurrence risk following DAA administration. DESIGN We pooled the data of 977 consecutive patients from 21 studies of HCV-related cirrhosis and HCC, who achieved complete radiological response after surgical/locoregional treatments and received DAAs (DAA group). Recurrence or death ...
2 CitationsSource
#1Paula IruzubietaH-Index: 13
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Background & Aims Mitochondria are the major organelles for the formation of reactive oxygen species (ROS) in the cell, and mitochondrial dysfunction has been described as a key factor in the pathogenesis of cholestatic liver disease. The methylation-controlled J-protein (MCJ) is a mitochondrial protein that interacts with and represses the function of complex I of the electron transport chain. The relevance of MCJ in the pathology of cholestasis has not yet been explored. Methods We studied the...
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#1Javier Crespo (UC: University of Cantabria)H-Index: 43
#2Pablo LázaroH-Index: 29
Last. Federico GarcíaH-Index: 35
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BACKGROUND Reflex testing is necessary to achieve the objectives of hepatitis C elimination. However, in 2017 only 31% of Spanish hospitals performed reflex test. As a consequence of that finding, reflex testing was recommended by scientific societies involved in the diagnosis and treatment of hepatitis C. OBJECTIVE To evaluate the degree of implementation of reflex testing in 2019 and to know the implementation of rapid diagnostic and/or dried blood spot testing (RDT and / or DBS) in Spanish ho...
6 CitationsSource
#1Jordi RimolaH-Index: 43
Last. Maria ReigH-Index: 33
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Abstract Background and Aims Immune-checkpoint inhibitors are effective in many advanced tumors. However, there is scarce information regarding the radiological response to these agents in hepatocellular carcinoma outside clinical trials. We aimed to describe the radiological response in a retrospective cohort of hepatocellular carcinoma patients treated with nivolumab and to analyze the radiological evolution according to tumor response at first posttreatment radiological assessment. Methods We...
2 CitationsSource