Chih-Hsin Tang
China Medical University (Taiwan)
Internal medicineEndocrinologyCell migrationMolecular biologyKinaseChemistryIntegrinImmunologyChondrosarcomaMetastasisAngiogenesisCancer researchMAPK/ERK pathwaySignal transductionMedicineProtein kinase BPI3K/AKT/mTOR pathwayBiologyCell biologyCancer cell
410Publications
73H-index
10.9kCitations
Publications 427
Newest
#1Chin-Horng SuH-Index: 1
#2Chih-Yang Lin (China Medical University (Taiwan))H-Index: 17
Last. Chih-Hsin TangH-Index: 73
view all 9 authors...
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#1Hsiang-Ping Lee (China Medical University (Taiwan))H-Index: 8
#2Shan-Chi Liu (China Medical University (Taiwan))H-Index: 14
Last. Chih-Hsin TangH-Index: 73
view all 10 authors...
Abstract null null Osteoarthritis (OA) is characterized by the infiltration and adhesion of monocyte into the joint synovium. Vascular cell adhesion molecule 1 (VCAM-1) is a critical cell adhesion molecule that controls monocyte motility during OA progression. Cordycerebroside A, a cerebroside compound isolated from Cordyceps militaris, inhibits the production of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) in synovial macrophages, but has not yet been investigated in OA. ...
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#5Min Huan Wu (THU: Tunghai University)H-Index: 1
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#1Chien-Chung HuangH-Index: 11
#2Yat-Yin LawH-Index: 2
Last. Chih-Hsin TangH-Index: 73
view all 8 authors...
Rheumatoid arthritis (RA) is an erosive polyarthritis that can lead to severe joint destruction and painful disability if left untreated. Angiogenesis, a critical pathogenic mechanism in RA, attracts inflammatory leukocytes into the synovium, which promotes production of proinflammatory cytokines and destructive proteases. Adipokines, inflammatory mediators secreted by adipose tissue, also contribute to the pathophysiology of RA. The most abundant serum adipokine is adiponectin, which demonstrat...
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#1Ko-Hsiu Lu (CSMU: Chung Shan Medical University)H-Index: 22
#2Peace Wun-Ang LuH-Index: 1
Last. Shun-Fa Yang (CSMU: Chung Shan Medical University)H-Index: 68
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Osteoarthritis (OA), the most common arthritis worldwide, is a degenerative joint disease characterized by progressive cartilage breakdown, subchondral remodeling, and synovial inflammation. Although conventional pharmaceutical therapies aimed to prevent further cartilage loss and joint dysfunction, there are no ideal strategies that target the pathogenesis of OA. Melatonin exhibits a variety of regulatory properties by binding to specific receptors and downstream molecules and exerts a myriad o...
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#6Cheng-Ta Lai (Mackay Memorial Hospital)H-Index: 2
Chondrosarcoma is a malignant bone tumor with high metastatic potential. Lymphangiogenesis is a critical biological step in cancer metastasis. WNT1-inducible signaling pathway protein 3 (WISP-3) regulates angiogenesis and facilitates chondrosarcoma metastasis, but the role of WISP-3 in chondrosarcoma lymphangiogenesis is unclear. In this study, incubation of chondrosarcoma cells with WISP-3 increased the production of VEGF-C, an important lymphangiogenic factor. Conditioned medium from WISP-3-tr...
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#1Kun-Tsan Lee (NCHU: National Chung Hsing University)
#2Bo-Cheng Chen (China Medical University (Taiwan))H-Index: 2
Last. Kwong-Chung Tung (NCHU: National Chung Hsing University)H-Index: 21
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The progression of osteoarthritis (OA) is mediated by adipokines, one of which is nesfatin-1, which is responsible for the production of inflammatory cytokines. However, how this molecule may affect the synthesis of the proinflammatory cytokine interleukin 1 beta (IL-1β) in OA is unclear. Our analyses of records from the Gene Expression Omnibus (GEO) dataset and clinical specimens of synovial tissue revealed higher levels of nesfatin-1 and IL-1β in OA samples compared with normal healthy tissue....
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#1Guan Yu Chen (China Medical University (Taiwan))H-Index: 6
#2Yi-Cheng Pan (AS: Academia Sinica)H-Index: 1
Last. Wei Chien Huang (AU: Asia University (Taiwan))H-Index: 30
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Abstract null null Background and aim null Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters cells through the binding of the viral spike protein with human angiotensin-converting enzyme 2 (ACE2), resulting in the development of coronavirus disease 2019 (COVID-19). To date, few antiviral drugs are available that can effectively block viral infection. This study aimed to identify potential natural products from Taiwan Database of Extracts and Compounds (TDEC) that may prevent th...
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#1Chun-Hao Tsai (China Medical University (Taiwan))H-Index: 32
#2Chao-Ju Chen (China Medical University (Taiwan))H-Index: 1
Last. Chih-Hsin Tang (CMU: Carnegie Mellon University)H-Index: 73
view all 9 authors...
Angiogenesis is a critical process in the formation of new capillaries and a key participant in rheumatoid arthritis (RA) pathogenesis. The chemokine (C-X-C motif) ligand 13 (CXCL13) plays important roles in several cellular functions such as infiltration, migration, and motility. We report significantly higher levels of CXCL13 expression in collagen-induced arthritis (CIA) mice compared with controls and also in synovial fluid from RA patients compared with human osteoarthritis (OA) samples. RA...
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#1Khuong T L Nguyen (China Medical University (Taiwan))
Last. Chih Yen Tu (China Medical University (Taiwan))H-Index: 27
view all 10 authors...
Targeting protein kinase C (PKC) family was found to repress the migration and resistance of non-small cell lung cancer cells to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). However, none of the PKC inhibitors has been approved for anticancer therapy yet due to the limited efficacy in clinical trials, and the underlying mechanisms remain unclear. l-lactic acidosis, a common condition comprising high l-lactate concentration and acidic pH in the tumor microenvironment...
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