Anders Bergh
Umeå University
CancerInternal medicineMicrocirculationEndocrinologyPathologyOncologyImmunohistochemistryProstateLeydig cellMetastasisTesticleCastrationProstate cancerAngiogenesisAdenocarcinomaCancer researchTestosteroneMedicineBiologyPCA3
381Publications
74H-index
13kCitations
Publications 378
Newest
#1Erik Bovinder Ylitalo (Umeå University)H-Index: 5
#2Elin Thysell (Umeå University)H-Index: 14
Last. Sofie Degerman (Umeå University)H-Index: 12
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BACKGROUND Patients with metastatic prostate cancer (PC) are treated with androgen deprivation therapy (ADT) that initially reduces metastasis growth, but after some time lethal castration-resistant PC (CRPC) develops. A better understanding of the tumor biology in bone metastases is needed to guide further treatment developments. Subgroups of PC bone metastases based on transcriptome profiling have been previously identified by our research team, and specifically, heterogeneities related to and...
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#1Anna-Maja Åberg (Umeå University)H-Index: 8
Last. Marie LundholmH-Index: 13
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Increasing evidence indicates calcium-binding S100 protein involvement in inflammation and tumor progression. In this prospective study, we evaluated the mRNA levels of two members of this family, S100A9 and S100A12, in peripheral blood mononuclear cells (PBMCs) in a cohort of 121 prostate cancer patients using RT-PCR. Furthermore, monocyte count was determined by flow cytometry. By stratifying patients into different risk groups, according to TNM stage, Gleason score and PSA concentration at di...
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#1Kristina Sandgren (Umeå University)H-Index: 2
#2Erik Nilsson (Umeå University)H-Index: 30
Last. Tufve Nyholm (Umeå University)H-Index: 22
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Abstract Background and purpose The diagnostic accuracy of new imaging techniques requires validation, preferably by histopathological verification. The aim of this study was to develop and present a registration procedure between histopathology and in-vivo magnetic resonance imaging (MRI) of the prostate, to estimate its uncertainty and to evaluate the benefit of adding a contour-correcting registration. Materials and methods For twenty-five prostate cancer patients, planned for radical prostat...
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#1Olof Lindahl (Umeå University)H-Index: 18
#2Tomas Bäcklund (Umeå University)H-Index: 8
Last. Anders Bergh (Umeå University)H-Index: 74
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Prostate cancer surgery risks erectile problems and incontinence for the patient. An instrument for guiding surgeons to avoid nerve bundle damage and ensure complete cancer removal is desirable. We present a tactile resonance sensor made of PZT ceramics, mounted in a 3D motorized translation stage for scanning and measuring tissue stiffness for detecting cancer in human prostate. The sensor may be used during surgery for guidance, scanning the prostate surface for the presence of cancer, indicat...
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#1Sofia Halin Bergström (Umeå University)H-Index: 8
#2Stina Häggström Rudolfsson (Umeå University)H-Index: 16
Last. Anders Bergh (Umeå University)H-Index: 74
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Prostate cancer is a multifocal disease, but if and how individual prostate tumours influence each other is largely unknown. We therefore explored signs of direct or indirect tumour-tumour interactions in experimental models and patient samples. Low-metastatic AT1 and high-metastatic MatLyLu (MLL) Dunning rat prostate cancer cells were injected into separate lobes of the ventral prostate of immunocompetent rats. AT1 tumours growing in the same prostate as MLL tumours had increased tumour size an...
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#1Kristina SandgrenH-Index: 2
#2Joakim JonssonH-Index: 14
Last. Tufve NyholmH-Index: 22
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#1Noopur Thakur (Ludwig Institute for Cancer Research)H-Index: 10
#2Anahita Hamidi (Ludwig Institute for Cancer Research)H-Index: 5
Last. Maréne Landström (Umeå University)H-Index: 29
view all 7 authors...
Summary Transforming growth factor β (TGF-β) enhances migration and invasion of cancer cells, causing life-threatening metastasis. Smad7 expression is induced by TGF-β to control TGF-β signaling in a negative feedback manner. Here we report an additional function of Smad7, i.e., to enhance TGF-β induction of c-Jun and HDAC6 via binding to their regulatory regions, promoting migration and invasion of prostate cancer cells. Lysine 102 in Smad7 is crucial for binding to specific consensus sites in ...
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#1Ilona Dudka (Umeå University)H-Index: 2
#2Elin Thysell (Umeå University)H-Index: 14
Last. Gerhard Gröbner (Umeå University)H-Index: 26
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BACKGROUND: Prostate cancer (PC) can display very heterogeneous phenotypes ranging from indolent asymptomatic to aggressive lethal forms. Understanding how these PC subtypes vary in their striving for energy and anabolic molecules is of fundamental importance for developing more effective therapies and diagnostics. Here, we carried out an extensive analysis of prostate tissue samples to reveal metabolic alterations during PC development and disease progression and furthermore between TMPRSS2-ERG...
5 CitationsSource
#1Erik Bovinder Ylitalo (Umeå University)H-Index: 5
#2Elin Thysell (Umeå University)H-Index: 14
Last. Pernilla Wikström (Umeå University)H-Index: 37
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BACKGROUND: Taxane treatment may be a suitable therapeutic option for patients with castration-resistant prostate cancer and high expression of constitutively active androgen receptor variants (AR-Vs). The aim of the study was to compare the effects of cabazitaxel and androgen deprivation treatments in a prostate tumor xenograft model expressing high levels of constitutively active AR-V7. Furthermore, mechanisms behind acquired cabazitaxel resistance were explored. METHODS: Mice were subcutaneou...
4 CitationsSource
#1Robert Rosenblatt (KI: Karolinska Institutet)H-Index: 9
#2Gabriella Lorentzi (Umeå University)H-Index: 1
Last. Amir Sherif (Umeå University)H-Index: 26
view all 11 authors...
AbstractObjective: To evaluate the extent and plausible effects of blood transfusions given during cisplatin-based neoadjuvant chemotherapy (NAC) on overall survival in patients with muscle-invasiv...
2 CitationsSource