Yujiro Takai
Toho University
Internal medicineRadiologySurgeryPathologyOncologyLung cancerChemotherapyExacerbationLungIdiopathic pulmonary fibrosisEpidermal growth factor receptorGefitinibAdenocarcinomaNon small cellInterstitial pneumoniaIn patientEgfr mutationCancer researchCirculating tumor cellMedicineGastroenterology
89Publications
12H-index
730Citations
Publications 91
Newest
#1Susumu SakamotoH-Index: 20
#2Hiroshige ShimizuH-Index: 6
Last. Kazutoshi IsobeH-Index: 13
view all 9 authors...
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#1Yoko Azuma (Toho University)H-Index: 5
#2Atsushi Sano (Toho University)H-Index: 6
Last. Akira Iyoda (Toho University)H-Index: 32
view all 10 authors...
BACKGROUND Chronic obstructive pulmonary disease (COPD) is an important risk factor for postoperative complications and mortality. To determine the effects of perioperative combination therapy, using a long-acting muscarinic antagonist (LAMA) and a long-acting β2 agonist (LABA), on preoperative lung function, postoperative morbidity and mortality, and long-term outcome in COPD patients. METHODS Between January 2005 and October 2019, 130 consecutive patients with newly diagnosed COPD underwent su...
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#1Susumu Sakamoto (Toho University)H-Index: 20
#2Marie Furukawa (Toho University)H-Index: 1
Last. Sakae Homma (Toho University)H-Index: 32
view all 14 authors...
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#1Kazutoshi Isobe (Toho University)H-Index: 13
#2Takahiro Yoshizawa (Toho University)H-Index: 2
Last. Kazuma Kishi (Toho University)H-Index: 23
view all 14 authors...
Background The response rate for osimertinib is high among patients with untreated epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC). However, there exist no biomarkers to predict the efficacy of the same. This study investigated whether BIM-γ mRNA expression in circulating tumor cells (CTCs) predicts poor outcomes for osimertinib treatment in patients with EGFR mutation-positive NSCLC. Methods Patients with advanced EGFR-tyrosine kinase inhibitor-untre...
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#1Akira Iyoda (Toho University)H-Index: 32
#2Yoko Azuma (Toho University)H-Index: 5
Last. Keigo TakagiH-Index: 11
view all 10 authors...
OBJECTIVES Silicone airway stents are used to manage central airway stenosis or obstruction, although their impact on long-term survival remains unknown in patients with central airway stenosis or obstruction due to thoracic malignancy. In this study, we retrospectively analyzed the impact of silicone stents on survival. METHODS We retrospectively analyzed clinical data of 106 patients with central airway stenosis or obstruction due to thoracic malignancy treated by stenting at Toho University O...
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#1Kazunori Isobe (Toho University)H-Index: 2
#2Hiroshi KobayashiH-Index: 4
Last. Kazuma KishiH-Index: 23
view all 8 authors...
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#1Susumu Sakamoto (Toho University)H-Index: 20
#2Marie Furukawa (Toho University)H-Index: 1
Last. Sakae Homma (Toho University)H-Index: 32
view all 14 authors...
Abstract Background Ultrasonic humidifier lung is a rare form of hypersensitivity pneumonitis (HP), and its clinical and radiological features are unclear. This study examined the clinical and radiological characteristics of humidifier lung. Methods Data from 18 patients with humidifier lung (mean age, 67.3 years) diagnosed during October 2012 through April 2018 were retrospectively reviewed. We compared clinical, laboratory, and CT findings and bronchoalveolar lavage fluid (BALF) characteristic...
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#1Yuta Nakano (Toho University)H-Index: 2
#2Kazutoshi Isobe (Toho University)H-Index: 13
Last. Kazuma Kishi (Toho University)H-Index: 23
view all 12 authors...
Long noncoding RNAs (lncRNAs) have been reported to be involved in the physiological and pathological processes of tumor pathogenesis, including epithelialmesenchymal transition (EMT). However, epidermal growth factor receptor (EGFR)tyrosine kinase inhibitor (TKI) resistance is a major challenge in the treatment of advanced and recurrent EGFRmutant lung adenocarcinoma. An increased understanding of the underlying mechanisms would aid in the development of effective therapeutic strategies against...
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#1Kazutoshi Isobe (Toho University)H-Index: 13
#2Takuma Issiki (Toho University)H-Index: 1
Last. Sakae Homma (Toho University)H-Index: 32
view all 7 authors...
Background: Reactive oxygen species (ROS) can play a role in the pathogenesis of Idiopathic Pulmonary Fibrosis (IPF) by contributing to epithelial damage. Bcl-2-like 11 ( BIM ) is involved in the generation of ROS via forkhead box O3 (FOXO3), and a BIM deletion polymorphism related to apoptosis has been reported to be specific to Asians. Here we examine the clinical features of IPF in patients with BIM deletion polymorphism. Methods: In this single-center retrospective study, we reviewed the med...
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#1Kazutoshi Isobe (Toho University)H-Index: 13
#2Yuta Nakano (Toho University)H-Index: 2
Last. Sakae Homma (Toho University)H-Index: 32
view all 11 authors...
e20529Background: Long noncoding RNA (lncRNA) is longer than 200 nucleotides and does not encode proteins. The IncRNA LINC00460 was reported to be involved in physiological and pathological process...
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