Robert G. Hahn
Karolinska Institutet
PharmacokineticsInternal medicineUrologyEndocrinologySurgeryAbsorption (skin)HemodynamicsChemistryVolume (thermodynamics)ProstateSalineUrineEthanolTransurethral resection of the prostateSpecific adsorptionAnesthesiaSodiumMedicineComplicationBlood pressure
398Publications
54H-index
6,904Citations
Publications 401
Newest
#1Michaela Gunnström (Linköping University)
#2Joachim Zdolsek (Linköping University)H-Index: 12
Last. Robert G. HahnH-Index: 54
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BACKGROUND Intraoperative administration of crystalloid for plasma volume expansion may be reduced by use of hyperoncotic albumin. However, the degree of plasma volume expansion with administration of 20% albumin is poorly quantitated. We estimated the amount of volume expansion attributable to 20% albumin administration in patients undergoing surgery for more than 5 hours. METHODS Twenty percent albumin was delivered at 3 mL/kg by intravenous infusion during 30 minutes to 15 patients (mean ± st...
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#1Robert G. Hahn (KI: Karolinska Institutet)H-Index: 54
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OBJECTIVES Systemic absorption of the irrigating fluid used to flush the operating site is a potentially serious complication in several types of endoscopic operations. To increase safety, many surgeons have changed from a monopolar to a bipolar resection technique because 0.9% saline can then be used instead of electrolyte-free fluid for irrigation. The present study examines whether the tendency for excessive plasma volume expansion is greater with saline than with electrolyte-free fluid. METH...
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#1Lukas M. Löffel (University of Bern)H-Index: 5
#2Robert G. Hahn (KI: Karolinska Institutet)H-Index: 54
Last. Patrick Y. Wuethrich (University of Bern)H-Index: 13
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Background The intraoperative effect of 20% albumin on plasma volume during surgery involving major blood loss has not been explored extensively due to methodological difficulties. Crystalloids poorly expand the plasma volume, and using a colloid might then be a way to avoid fluid overload. As doubts have been raised about synthetic colloids, albumin solutions are currently used more extensively. This study presents a methodological development showing how plasma volume expansion can be studied ...
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#1Dominique Engel (University of Bern)H-Index: 2
#2Lukas M. Löffel (University of Bern)H-Index: 5
Last. Robert G. Hahn (KI: Karolinska Institutet)H-Index: 54
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Background. Postoperative elevation of plasma creatinine is a frequent complication to major surgery. A rise by 50% fulfils the criterion for Acute Kidney Injury. We studied the relationship between concentrated urine before surgery, which is a sign of dehydration or chronically low intake of water, and the perioperative change in plasma creatinine. Methods. The creatinine concentration was measured in plasma and urine just before and at 6 h, 1 day, and 2 days after major abdominal surgery in a ...
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#1Fumitaka Yanase (Austin Hospital)H-Index: 1
#2Shervin Tosif (Austin Hospital)H-Index: 2
Last. Bernhard Riedel (Peter MacCallum Cancer Centre)H-Index: 22
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Background null The endothelial glycocalyx, a carbohydrate-rich layer coating all endothelial surfaces, plays a fundamental role in the function of microcirculation. The primary aim of this study was to evaluate the feasibility of using dexamethasone and albumin to protect the endothelial glycocalyx in patients undergoing abdominal surgery. Secondary and exploratory outcomes included efficacy and safety. null Methods null We conducted a multicenter, open-label, blinded end point, phase 2, random...
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#1Robert G. Hahn (KI: Karolinska Institutet)H-Index: 54
#2Dan DrobinH-Index: 12
BACKGROUND Crystalloid fluid infused during the induction of spinal anesthesia is involved in a complex set of physiological responses, including vasodilatation, reactive vasoconstriction, and changes in mean arterial pressure (MAP). The present evaluation compares the modeled capillary leakage in anesthetized versus non-anesthetized body regions. METHODS Ten female volunteers (mean age, 29 years) received 25 mL/kg of Ringer´s acetate over 60 min during experimental spinal anesthesia. Blood hemo...
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#1Robert G. Hahn (KI: Karolinska Institutet)H-Index: 54
#2Marc Giménez-Milà (University of Barcelona)H-Index: 6
OBJECTIVES To report our data on the total body water (TBW), intracellular volume (ICV), extracellular volume (ECV), and fat-free mass (FFM) from studies using whole-body bioimpedance (BIA) with the aim of contrasting them to commonly cited reference values. METHODS Data were retrospectively retrieved from three single-center studies of adult healthy male volunteers and one study of women scheduled for abdominal hysterectomy where multifrequency BIA had been applied to obtain measurements of TBW...
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#1Robert G. Hahn (KI: Karolinska Institutet)H-Index: 54
#2Patrick Y. Wuethrich (University of Bern)H-Index: 13
Last. Joachim Zdolsek (Linköping University)H-Index: 12
view all 3 authors...
BACKGROUND Trends in non-invasive measurements of blood hemoglobin (Hb) may be useful for identifying the need for transfusion in the perioperative period. METHODS Crystalloid fluid (5-20 mL/kg) was administered intravenously or by mouth to 30 volunteers and 33 surgical patients in five non-randomized clinical studies where Hb was measured on 915 occasions by non-invasive (Radical-7™) and invasive methodology. The hemodilution curves were compared by volume kinetic analysis and linear regression...
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#1Robert G. HahnH-Index: 54
#2Randal O. Dull (UA: University of Arizona)H-Index: 5
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