Devika B. Chithrani
University of Victoria
Colloidal goldCancerQuantum dotBiophysicsCellNanomedicineNanoparticleNanotechnologyChemical beam epitaxyChemistryMaterials scienceHeLaDrug deliveryNano-OptoelectronicsCancer researchRadiation therapyMedicineIntracellularCancer cell
50Publications
16H-index
1,411Citations
Publications 49
Newest
About half of cancer patients (50%) receive radiotherapy (RT) for the treatment of local tumors. However, one of the main obstacles in RT is the close proximity of adjacent organs at risk, resulting in treatment doses being limited by significant tissue toxicity, hence preventing the necessary dose escalation that would guarantee local control. Effective local cancer therapy is needed to avoid progression of tumors and to decrease the development of systemic metastases which may further increase...
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#1Kyle BrommaH-Index: 5
Last. Devika B. ChithraniH-Index: 16
view all 6 authors...
Radiotherapy and chemotherapy are the gold standard for treating patients with cancer in the clinic but, despite modern advances, are limited by normal tissue toxicity. The use of nanomaterials, such as gold nanoparticles (GNPs), to improve radiosensitivity and act as drug delivery systems can mitigate toxicity while increasing deposited tumor dose. To expedite a quicker clinical translation, three-dimensional (3D) tumor spheroid models that can better approximate the tumor environment compared ...
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#1Abdulaziz Alhussan (UVic: University of Victoria)
#2Kyle Bromma (UVic: University of Victoria)H-Index: 5
Last. Devika B. Chithrani (UVic: University of Victoria)H-Index: 16
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Pancreatic cancer is one of the deadliest with a 5-year survival of 6 to 9%. Nanotechnology offers paradigm-changing opportunity to treat such cancers. Successful integration of nanotechnology into the current paradigm of cancer therapy requires proper understanding of the interface between nanoparticles (NPs) and cancer cells, as well as other key components within the tumor microenvironment (TME), such as normal fibroblasts (FBs) and cancer-associated FBs (CAFs). So far, much focus has been on...
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According to the global cancer observatory (GLOBOCAN), there are approximately 18 million new cancer cases per year worldwide. Cancer therapies are largely limited to surgery, radiotherapy, and chemotherapy. In radiotherapy and chemotherapy, the maximum tolerated dose is presently being used to treat cancer patients. The integrated development of innovative nanoparticle (NP) based approaches will be a key to address one of the main issues in both radiotherapy and chemotherapy: normal tissue toxi...
5 CitationsSource
#1Kyle Bromma (UVic: University of Victoria)H-Index: 5
#2Aaron Bannister (UVic: University of Victoria)H-Index: 2
Last. Devika B. Chithrani (UVic: University of Victoria)H-Index: 16
view all 5 authors...
2 CitationsSource
#1Kyle Bromma (UVic: University of Victoria)H-Index: 5
#2Leah Cicon (UVic: University of Victoria)H-Index: 2
Last. Devika B. ChithraniH-Index: 16
view all 4 authors...
One of the major issues in cancer radiotherapy (RT) is normal tissue toxicity. Introduction of radiosensitizers like gold nanoparticles (GNPs) into cancer cells to enhance the local RT dose has been tested successfully. However, it is not known how GNPs interact with other stromal cells such as normal fibroblasts (FBs) and cancer associated fibroblasts (CAFs) within the tumour microenvironment. It is known that FBs turn into CAFs to promote tumour growth. Hence, we used FBs and CAFs along with H...
5 CitationsSource
#1Aaron Bannister (UVic: University of Victoria)H-Index: 2
#2Dushanthi Dissanayake (UVic: University of Victoria)
Last. Devika B. Chithrani (UVic: University of Victoria)H-Index: 16
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Nanoparticles (NPs) have shown promise in both radiotherapy and chemotherapy. NPs are mainly transported along cellular microtubules (MTs). Docetaxel (DTX) is a commonly used chemotherapeutic drug that can manipulate the cellular MT network to maximize its clinical benefit. However, the effect of DTX on NP behaviour has not yet been fully elucidated. We used gold NPs of diameters 15 and 50 nm at a concentration of 0.2 nM to investigate the size dependence of NP behaviour. Meanwhile, DTX concentr...
1 CitationsSource
#1Jan Schuemann (Harvard University)H-Index: 22
#2Alexander F. Bagley (University of Texas MD Anderson Cancer Center)H-Index: 3
Last. Sunil Krishnan (Mayo Clinic)H-Index: 63
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This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z=22, to Bismuth, Z=83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are bein...
14 CitationsSource
#1Aaron Bannister (UVic: University of Victoria)H-Index: 2
#2Kyle Bromma (UVic: University of Victoria)H-Index: 5
Last. Devika B. ChithraniH-Index: 16
view all 9 authors...
Objective:One of the major issues in current radiotherapy (RT) is the normal tissue toxicity. A smart combination of agents within the tumor would allow lowering the RT dose required while minimizi...
8 CitationsSource
#1Kristy Rieck (UVic: University of Victoria)H-Index: 2
#2Kyle Bromma (UVic: University of Victoria)H-Index: 5
Last. Devika B. Chithrani (UVic: University of Victoria)H-Index: 16
view all 6 authors...
Objective: The incorporation of high atomic number materials such as gold nanoparticles (GNPs) into tumor cells is being tested to enhance the local radiotherapy (RT) dose. It is also known that th...
5 CitationsSource