Subhash C. Chauhan
University of Texas at Austin
PhysicsCancerInternal medicinePathologyChemistryApoptosisImmunologyOrmeloxifeneCervical cancerCurcuminMetastasisDrug deliveryProstate cancerPancreatic cancerCell cycleCancer researchCell growthMedicineBiologyCancer cellPharmacology
277Publications
49H-index
6,392Citations
Publications 255
Newest
#1Partha Laskar (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 5
#2Murali M. Yallapu (University of Texas at Austin)H-Index: 34
Last. Subhash C. Chauhan (University of Texas at Austin)H-Index: 5
view all 3 authors...
The outbreak of novel coronavirus disease (2019-nCoV or COVID-19) is responsible for severe health emergency throughout the world. The attack of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is found to be responsible for COVID-19. The World Health Organization has declared the ongoing global public health emergency as a pandemic. The whole world fights against this invincible enemy in various capacities to restore economy, lifestyle, and safe life. Enormous amount of scientific r...
6 CitationsSource
#1Elham Hatami (UTHSC: University of Tennessee Health Science Center)H-Index: 6
#2Meena Jaggi (UTHSC: University of Tennessee Health Science Center)H-Index: 36
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 3
view all 4 authors...
Abstract The United State Food and Drug Administration has permitted number of therapeutic agents for cancer treatment. Most of them are expensive and have some degree of systemic toxicity which makes overbearing in clinical settings. Although advanced research continuously applied in cancer therapeutics, but drug resistance, metastasis, and recurrence remain unanswerable These accounts to an urgent clinical need to discover natural compounds with precisely safe and highly efficient for the canc...
5 CitationsSource
#1Anupam Dhasmana (University of Texas at Austin)H-Index: 7
#2Swati Uniyal (Gautam Buddha University)H-Index: 3
Last. Subhash C. Chauhan (University of Texas at Austin)H-Index: 5
view all 11 authors...
Curcumin is an important bioactive component of turmeric and also one of the important natural products, which has been investigated extensively. The precise mode of action of curcumin and its impact on system level protein networks are still not well studied. To identify the curcumin governed regulatory action on protein interaction network (PIN), an interectome was created based on 788 key proteins, extracted from PubMed literatures, and constructed by using STRING and Cytoscape programs. The ...
3 CitationsSource
#1Mehdi Chaib (UTHSC: University of Tennessee Health Science Center)H-Index: 3
#2Subhash C. Chauhan (University of Texas at Austin)H-Index: 49
Last. Liza Makowski (UTHSC: University of Tennessee Health Science Center)H-Index: 35
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The tumor microenvironment (TME) is a complex network of epithelial and stromal cells, wherein stromal components provide support to tumor cells during all stages of tumorigenesis. Among these stromal cell populations are myeloid cells, which are comprised mainly of tumor-associated macrophages (TAM), dendritic cells (DC), myeloid-derived suppressor cells (MDSC), and tumor-associated neutrophils (TAN). Myeloid cells play a major role in tumor growth through nurturing cancer stem cells by providi...
5 CitationsSource
#1Yoo-Duk Choi (Chonnam National University)H-Index: 16
#2Ji-Yeon Jung (Chonnam National University)H-Index: 15
Last. Mihwa Kim (University of Texas at Austin)H-Index: 6
view all 12 authors...
Pancreatic cancer is the worst exocrine gastrointestinal cancer leading to the highest mortality. Recent studies reported that aberrant expression of apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) is involved in uncontrolled cell growth. However, the molecular mechanism of APE1 biological role remains unrevealed in pancreatic cancer progression. Here, we demonstrate that APE1 accelerates pancreatic cancer cell proliferation through glial cell line-derived neurotrophic factor (GDNF)/glial f...
3 CitationsSource
#1Advait B. Shetty (UTHSC: University of Tennessee Health Science Center)H-Index: 3
#2Prashanth K.B. Nagesh (University of Texas at Austin)H-Index: 10
Last. Subhash C. Chauhan (University of Texas at Austin)H-Index: 49
view all 7 authors...
Pancreatic cancer (PanCa) is a highly lethal disease with a poor 5 year survival rate, less than 7%. It has a dismal prognosis, and more than 50% of cases are detected at an advanced and metastatic stage. Gemcitabine (GEM) is a gold standard chemotherapy used for PanCa treatment. However, GEM-acquired resistance in cancer cells is considered as a major setback for its continued clinical implementation. This phenomenon is evidently linked to de novo lipid synthesis. PanCa cells rely on de novo li...
Source
#1Andrew E. Massey (University of Texas at Austin)H-Index: 5
#2Kyle Doxtater (University of Texas at Austin)H-Index: 3
Last. Subhash C. Chauhan (University of Texas at Austin)H-Index: 49
view all 4 authors...
Abstract Background Pancreatic cancer is one of the most lethal cancers in the United States. This is partly due to the difficulty in early detection of this disease as well as poor therapeutic responses to currently available regimens. Our previous reports suggest that mucin 13 (MUC13, a transmembrane mucin common to gastrointestinal cells) is aberrantly expressed in this disease state, and has been implicated with a worsened prognosis and an enhanced metastatic potential in PanCa. However, the...
Source
#1Sabina Ranjit (UTHSC: University of Tennessee Health Science Center)H-Index: 6
#2Sunitha Kodidela (UTHSC: University of Tennessee Health Science Center)H-Index: 11
Last. Santosh Kumar (UTHSC: University of Tennessee Health Science Center)H-Index: 96
view all 5 authors...
In the current study, we hypothesized that extracellular vesicles (EVs) secreted from human papilloma virus (HPV)-infected cervical cancer cells exacerbate human immunodeficiency virus (HIV)-1 replication in differentiated U1 cell line through an oxidative stress pathway. To test the hypothesis, we treated an HIV-1-infected macrophage cell line (U1) with HPV-infected Caski cell culture supernatant (CCS). We observed a significant increase in HIV-1 replication, which was associated with an increa...
4 CitationsSource
#1Vivek K. Kashyap (UTHSC: University of Tennessee Health Science Center)H-Index: 8
#1Vivek Kumar Kashyap (UTHSC: University of Tennessee Health Science Center)H-Index: 1
Last. Subhash C. Chauhan (UTHSC: University of Tennessee Health Science Center)H-Index: 5
view all 14 authors...
Abstract In this study, we investigated the therapeutic efficacy of VERU-111 in vitro and in vivo model systems of cervical cancer. VERU-111 treatment inhibited cell proliferation and, clonogenic potential, induce accumulation of p53 and down regulated the expression of HPV E6/E7 expression in cervical cancer cells. In addition, VERU-111 treatment also decreased the expression of phosphorylation of Jak2 (TyR1007/1008) and STAT3 at Tyr705 and Ser727. VERU-111 treatment arrested cell cycle in the ...
2 CitationsSource
#1Prashanth K.B. Nagesh (University of Texas at Austin)H-Index: 10
#2Pallabita Chowdhury (UTHSC: University of Tennessee Health Science Center)H-Index: 12
Last. Murali M. Yallapu (University of Texas at Austin)H-Index: 34
view all 9 authors...
Prostate cancer (PCa) cells exploit the aberrant lipid signaling and metabolism as their survival advantage. Also, intracellular storage lipids act as fuel for the PCa proliferation. However, few studies were available that addressed the topic of targeting lipid metabolism in PCa. Here, we assessed the tannic acid (TA) lipid-targeting ability and its capability to induce endoplasmic reticulum (ER) stress by reactive oxygen species (ROS) in PCa cells. TA exhibited dual effects by inhibiting lipog...
5 CitationsSource