Subhash C. Chauhan
University of Texas at Austin
PhysicsCancerInternal medicinePathologyChemistryApoptosisImmunologyOrmeloxifeneCervical cancerCurcuminMetastasisDrug deliveryProstate cancerPancreatic cancerCell cycleCancer researchCell growthMedicineBiologyCancer cellPharmacology
277Publications
49H-index
6,392Citations
Publications 255
Newest
#1Bilal Bin Hafeez (UT: University of Tennessee)H-Index: 29
#2Aditya Ganju (UT: University of Tennessee)H-Index: 12
Last. Meena Jaggi (UT: University of Tennessee)H-Index: 36
view all 15 authors...
Ormeloxifene (ORM), is a clinically approved selective estrogen receptor modulator, which has also shown excellent anti-cancer activity, thus it can be an ideal repurposing pharmacophore. Herein, we report therapeutic effects of ORM on prostate cancer (PrCa) and elucidate a novel molecular mechanism of its anti-cancer activity. ORM treatment inhibited epithelial to mesenchymal transition (EMT) process as evident by repression of N-cadherin, Slug, Snail, and vimentin, MMPs (MMP2 and MMP3), β-cate...
23 CitationsSource
#1Pallabita Chowdhury (UTHSC: University of Tennessee Health Science Center)H-Index: 12
#2Prashanth K.B. Nagesh (UTHSC: University of Tennessee Health Science Center)H-Index: 10
Last. Murali M. Yallapu (UTHSC: University of Tennessee Health Science Center)H-Index: 34
view all 7 authors...
Abstract The goal of this investigation was to develop and demonstrate a polymer/paclitaxel self-assembly (PTX-SA) formulation. Polymer/PTX-SAs were screened based on smaller size of formulation using dynamic light scattering analysis. Additionally, fluorescence microscopy and flow cytometry studies exhibited that polyvinylpyrrolidone (PVP)-based PTX-SAs (PVP/PTX-SAs) had superior cellular internalization capability in MCF7 and MDA-MB-231 breast cancer cells. The optimized PVP/PTX-SAs exhibited ...
27 CitationsSource
#1Pallabita Chowdhury (UTHSC: University of Tennessee Health Science Center)H-Index: 12
#2Allison M. Roberts (UTHSC: University of Tennessee Health Science Center)H-Index: 1
Last. Murali M. Yallapu (UTHSC: University of Tennessee Health Science Center)H-Index: 34
view all 7 authors...
Magnetic nanoparticles (MNPs) play a vital role for improved imaging applications. Recently, a number of studies demonstrate MNPs can be applied for targeted delivery, sustained release of therapeutics, and hyperthermia. Based on stable particle size and shape, biocompatibility, and inherent contrast enhancement characteristics, MNPs have been encouraged for pre-clinical studies and human use. As a theranostic platform development, MNPs need to balance both delivery and imaging aspects. Thus, th...
6 CitationsSource
#1Mohammed Sikander (UTHSC: University of Tennessee Health Science Center)H-Index: 7
#2Bilal Bin Hafeez (UTHSC: University of Tennessee Health Science Center)H-Index: 29
Last. Meena Jaggi (UTHSC: University of Tennessee Health Science Center)H-Index: 36
view all 8 authors...
Background: Emergence of hormone-refractory PrCa (HRPC) after the anti-androgen therapy, cancer metastasis and chemo-resistance are the major hurdle for the treatment of prostate cancer (PrCa) patients. Accumulative evidence suggests that altered glucose metabolism is one of the mechanisms for metastatic PrCa cell survival and chemo-resistance. Therefore, identification and generation of natural/or synthetic pharmacological agents that can limit altered glucose metabolism might be highly useful ...
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#2Pallabita ChowdhuryH-Index: 12
Last. Murali M. YallapuH-Index: 34
view all 9 authors...
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#1Saini SetuaH-Index: 7
#2Sheema KhanH-Index: 23
Last. Subhash C. ChauhanH-Index: 49
view all 7 authors...
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#1Sonam KumariH-Index: 8
#2Sheema KhanH-Index: 23
Last. Meena JaggiH-Index: 36
view all 7 authors...
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#1Aditya GanjuH-Index: 12
#2Bilal Bin HafeezH-Index: 29
Last. Meena JaggiH-Index: 36
view all 7 authors...
Background: Prostate cancer (PrCa) first manifests as an androgen-dependent disease and can be treated with androgen-deprivation therapy. Despite the initial success of androgen ablation therapy, resistance to anti-androgen therapy displays by progression to hormone refractory (androgen-independent) advanced stage PrCa which is primary cause of patient’s death. Main underlying cause for the onset of hormone refractory cancer is ligand independent activation of AR signaling in PrCa cells. It has ...
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#1Vivek K. KashyapH-Index: 8
#2Bilal Bin HafeezH-Index: 29
Last. Subhash C. ChauhanH-Index: 49
view all 11 authors...
Introduction: Pancreatic cancer (PanCa) is one of the most fatal cancers and is ranked as the fourth common cause of cancer-related deaths among both men and women in the US. The management of PanCa is exceptionally difficult due to the extremely poor response to available chemotherapeutic drugs. Microtubules are dynamic structures composed of α-β-tubulin heterodimers that are essential in cell division and are important targets for several clinical drugs (paclitaxel, docetaxel and vinblastine)....
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#2Pallabita ChowdhuryH-Index: 12
Last. Murali M. YallapuH-Index: 34
view all 11 authors...
1 CitationsSource