Shiv Pillai
Ragon Institute of MGH, MIT and Harvard
B-1 cellAntigenMolecular biologyCytotoxic T cellAntibodyChemistryNaive B cellImmunologyT cellB cellDiseaseIgG4-related diseaseCancer researchGeneticsBiochemistryMedicineBiologyImmune systemCell biologyGerminal center
222Publications
50H-index
13.7kCitations
Publications 297
Newest
#1David A. Fox (UM: University of Michigan)H-Index: 56
#2Steven K. Lundy (UM: University of Michigan)H-Index: 30
Last. Dinesh Khanna (UM: University of Michigan)H-Index: 68
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#1Damian R. Plichta (Broad Institute)H-Index: 14
#2Juhi Somani (Aalto University)H-Index: 2
Last. Ramnik J. Xavier (Broad Institute)H-Index: 124
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BACKGROUND Immunoglobulin G4-related disease (IgG4-RD) and systemic sclerosis (SSc) are rare autoimmune diseases characterized by the presence of CD4+ cytotoxic T cells in the blood as well as inflammation and fibrosis in various organs, but they have no established etiologies. Similar to other autoimmune diseases, the gut microbiome might encode disease-triggering or disease-sustaining factors. METHODS The gut microbiomes from IgG4-RD and SSc patients as well as healthy individuals with no rece...
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#1Marco Lanzillotta (UniSR: Vita-Salute San Raffaele University)H-Index: 14
#2Miriam Sant'Angelo (UniSR: Vita-Salute San Raffaele University)
Last. Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 25
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#2Faisal AlsufyaniH-Index: 2
Last. Shiv PillaiH-Index: 50
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Although fibrotic disorders are frequently assumed to be linked to TH2 cells, quantitative tissue interrogation studies have rarely been performed to establish this link and certainly many fibrotic diseases do not fall within the type 2/allergic disease spectrum. We have previously linked two human autoimmune fibrotic diseases, IgG4-related disease and systemic sclerosis, to the clonal expansion and lesional accumulation of CD4+CTLs. In both these diseases TH2 cell accumulation was found to be s...
1 CitationsSource
#1Lucrezia Rovati (UniSR: Vita-Salute San Raffaele University)H-Index: 6
#2Naoki Kaneko (Ragon Institute of MGH, MIT and Harvard)H-Index: 10
Last. Emanuel Della-Torre (UniSR: Vita-Salute San Raffaele University)H-Index: 25
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OBJECTIVES IgG4-related disease (IgG4-RD) is a systemic fibro-inflammatory disorder characterized by a dysregulated resolution of inflammation and wound healing response that might develop after an apoptotic insult induced by cytotoxic T lymphocytes (CTLs). Mer receptor tyrosine kinase (MerTK) and its ligand Protein S (ProS1) have a pivotal role in the resolution of inflammation, being implicated in the clearance of apoptotic cells, quenching of the immune response and development of tissue fibr...
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#1David A. Fox (UM: University of Michigan)H-Index: 56
#2Steven K. Lundy (UM: University of Michigan)H-Index: 30
Last. Dinesh Khanna (UM: University of Michigan)H-Index: 6
view all 15 authors...
BACKGROUND Abnormalities in lymphocyte surface markers and functions have been described in systemic sclerosis (SSc), but conflicting results abound, and these studies often examined patients with heterogeneous disease duration, severity, clinical phenotype, and concurrent immunosuppressive agents. We studied a clinically homogeneous group of early diffuse cutaneous SSc patients not exposed to immunosuppressive drugs who were enrolled in a clinical trial and compared their immune parameters to h...
1 CitationsSource
#1Cory A. Perugino (Harvard University)H-Index: 13
#2Naoki Kaneko (Kyushu University)H-Index: 10
Last. Shiv Pillai (Ragon Institute of MGH, MIT and Harvard)H-Index: 50
view all 28 authors...
Abstract Background IgG4-related disease (IgG4-RD) is an immune-mediated fibrotic disorder that has been linked to CD4+ cytotoxic T lymphocytes (CD4+CTLs). The effector phenotype of CD4+CTLs, the relevance of both CD8+ cytotoxic T lymphocytes (CD8+CTLs) and of apoptotic cell death remain undefined in IgG4-RD. Objective The goals of this study were to define CD4+CTL heterogeneity, characterize the CD8+CTL response in the blood and in lesions, and determine whether enhanced apoptosis may contribut...
9 CitationsSource
#1Naoki Kaneko (Ragon Institute of MGH, MIT and Harvard)H-Index: 10
#2Hsiao-Hsuan Kuo (Ragon Institute of MGH, MIT and Harvard)H-Index: 5
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Humoral responses in coronavirus disease 2019 (COVID-19) are often of limited durability, as seen with other human coronavirus epidemics. To address the underlying etiology, we examined post mortem thoracic lymph nodes and spleens in acute SARS-CoV-2 infection and observed the absence of germinal centers and a striking reduction in Bcl-6+ germinal center B cells but preservation of AID+ B cells. Absence of germinal centers correlated with an early specific block in Bcl-6+ TFH cell differentiatio...
146 CitationsSource
#1E. Della TorreH-Index: 1
#2Marco LanzillottaH-Index: 14
Last. Shiv PillaiH-Index: 50
view all 5 authors...
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#1Yuta Asano (U of C: University of Chicago)H-Index: 1
#2Joe Daccache (Brigham and Women's Hospital)H-Index: 1
Last. Marcus R. Clark (U of C: University of Chicago)H-Index: 40
view all 15 authors...
1 CitationsSource
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