Marina Rosso
Instituto de Biología y Medicina Experimental
Messenger RNACancerInternal medicineCell migrationVimentinCellCadherinSmall interfering RNACDH1MatrigelTumor progressionOvarian tumorOvarian cancerCancer researchBreast cancerTransfectionBioinformaticsMedicineEpithelial–mesenchymal transitionBiology
12Publications
6H-index
93Citations
Publications 12
Newest
#1María Victoria Mencucci (Instituto de Biología y Medicina Experimental)H-Index: 2
#2Lara Lapyckyj (Instituto de Biología y Medicina Experimental)H-Index: 6
Last. Mónica H. Vazquez-Levin (Instituto de Biología y Medicina Experimental)H-Index: 21
view all 13 authors...
Bladder cancer (BC) is the ninth most common cancer worldwide, but molecular changes are still under study. During tumor progression, Epithelial cadherin (E-cadherin) expression is altered and β-catenin may be translocated to the nucleus, where it acts as co-transcription factor of tumor invasion associated genes. This investigation further characterizes E-cadherin and β-catenin associated changes in BC, by combining bioinformatics, an experimental murine cell model (MB49/MB39-I) and human BC sa...
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#1María José Besso (Instituto de Biología y Medicina Experimental)H-Index: 4
#2Marina Rosso (Instituto de Biología y Medicina Experimental)H-Index: 6
Last. Mónica H. Vazquez-Levin (Instituto de Biología y Medicina Experimental)H-Index: 21
view all 13 authors...
Objective: Endometrial cancer (EC) is the second most common gynecological cancer worldwide. Myometrial invasion (MI) is a key event in EC dissemination. This study aimed to evaluate FXYD5/dysadherin (FXYD5/Dys) expression in EC tissue and uterine aspirate (UA) biopsies and to assess molecular/functional changes associated with its expression in cellular models. Methods: FXYD5/Dys messenger RNA (mRNA) levels were determined in EC tissue and UA biopsies. FXYD5/Dys expression was evaluated in EC R...
3 CitationsSource
#1Marina Rosso (Instituto de Biología y Medicina Experimental)H-Index: 6
#2Lara Lapyckyj (Instituto de Biología y Medicina Experimental)H-Index: 6
Last. Mónica H. Vazquez-Levin (Instituto de Biología y Medicina Experimental)H-Index: 21
view all 9 authors...
Background Breast cancer (BC) is the most common female cancer and the leading cause of cancer death in women worldwide. Alterations in epithelial cadherin (E-cadherin) expression and functions are associated to BC, but the underlying molecular mechanisms have not been fully elucidated. We have previously reported a novel human E-cadherin splice variant (E-cadherin variant) mRNA. Stable transfectants in MCF-7 human BC cells (MCF7Ecadvar) depicted fibroblast-like cell morphology, E-cadherin wild-...
5 CitationsSource
#1Marina Rosso (Instituto de Biología y Medicina Experimental)H-Index: 6
#2Blanca MajemH-Index: 13
Last. Mónica H. Vazquez-Levin (Instituto de Biología y Medicina Experimental)H-Index: 21
view all 17 authors...
Ovarian cancer (OC) is the fifth cancer death cause in women worldwide. The malignant nature of this disease stems from its unique dissemination pattern. Epithelial-to-mesenchymal transition (EMT) has been reported in OC and downregulation of Epithelial cadherin (E-cadherin) is a hallmark of this process. However, findings on the relationship between E-cadherin levels and OC progression, dissemination and aggressiveness are controversial. In this study, the evaluation of E-cadherin expression in...
30 CitationsSource
#1María Laura Matos (Instituto de Biología y Medicina Experimental)H-Index: 5
#2Lara Lapyckyj (Instituto de Biología y Medicina Experimental)H-Index: 6
Last. Mónica H. Vazquez-Levin (Instituto de Biología y Medicina Experimental)H-Index: 21
view all 9 authors...
: Epithelial Cadherin (E-cadherin) is involved in calcium-dependent cell-cell adhesion and signal transduction. The E-cadherin decrease/loss is a hallmark of Epithelial to Mesenchymal Transition (EMT), a key event in tumor progression. The underlying molecular mechanisms that trigger E-cadherin loss and consequent EMT have not been completely elucidated. This study reports the identification of a novel human E-cadherin variant mRNA produced by alternative splicing. A bioinformatics evaluation of...
21 CitationsSource
#1Monica Hebe Vazquez (Instituto de Biología y Medicina Experimental)H-Index: 7
#2María Victoria Mencucci (Instituto de Biología y Medicina Experimental)H-Index: 2
Last. Marina Rosso (Instituto de Biología y Medicina Experimental)H-Index: 6
view all 4 authors...
Fil: Vazquez, Monica Hebe. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Instituto de Biologia y Medicina Experimental. Fundacion de Instituto de Biologia y Medicina Experimental. Instituto de Biologia y Medicina Experimental; Argentina
#2María José BessoH-Index: 4
Last. Mónica H. Vazquez-Levin (Instituto de Biología y Medicina Experimental)H-Index: 21
view all 8 authors...
Display Omitted A systematic study was carried out to gather and summarize current knowledge on CDH1/E-cadherin and solid tumors (ST) using bioinformatics resources. The DisGeNET database was exploited to survey CDH1-associated diseases. Reported mutations in specific ST were obtained by interrogating COSMIC and IntOGen tools. CDH1 single nucleotide polymorphisms (SNP) were retrieved from the dbSNP database.DisGeNET analysis identified 609 genes annotated to ST, among which CDH1 was listed. Usin...
5 CitationsSource
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#1Marina Rosso (Instituto de Biología y Medicina Experimental)H-Index: 6
#2Blanca MajemH-Index: 13
Last. Mónica H. Vazquez-Levin (Instituto de Biología y Medicina Experimental)H-Index: 21
view all 16 authors...
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA Ovarian cancer (OC) is the 5th leading cause of cancer deaths in women worldwide due to late symptoms and its diagnosis at advanced stages. Epithelial to mesenchymal transition (EMT) is an important step in cancer invasion/metastasis and downregulation of Epithelial cadherin (Ecad) is a critical feature of this process. Ecad expression was evaluated in 100 OC tissue sections, finding a decreased Ecad signal along tu...
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#1Lucía Saucedo (Instituto de Biología y Medicina Experimental)H-Index: 3
#2Gabriela N. Buffa (Instituto de Biología y Medicina Experimental)H-Index: 1
Last. Clara I. Marín-Briggiler (Instituto de Biología y Medicina Experimental)H-Index: 16
view all 8 authors...
Fibroblast growth factors receptors (FGFRs) have been widely characterized in somatic cells, but there is scarce evidence of their expression and function in mammalian gametes. The objective of the present study was to evaluate the expression of FGFRs in human male germ cells, to determine sperm FGFR activation by the FGF2 ligand and their participation in the regulation of sperm motility. The expression of FGFR1, 2, 3 and 4 mRNAs and proteins in human testis and localization of these receptors ...
18 CitationsSource