Eunsil Yu
University of Ulsan
CancerInternal medicineRadiologySurgeryPathologyOncologyImmunohistochemistryBiopsyCarcinomaLiver biopsyHepatocellular carcinomaPancreasLiver transplantationBile ductHepatitis B virusAdenocarcinomaCancer researchMedicineBiologyGastroenterology
Publications 194
#1Jihyun An (Hanyang University)H-Index: 4
#2Deokhoon Kim (UOU: University of Ulsan)H-Index: 16
Last. Won-Kyung Kim (UOU: University of Ulsan)H-Index: 3
view all 19 authors...
BACKGROUND AND AIMS Despite the epidemiological association between intrahepatic cholangiocarcinoma (iCCA) and hepatitis B virus (HBV) infection, little is known about the relevant oncogenic effects. We sought to identify the landscape and mechanism of HBV integration, along with the genomic architecture of HBV-infected iCCA tumors. APPROACH AND RESULTS We profiled a cohort of 108 HBV-infected iCCAs using whole-genome sequencing, deep sequencing, and RNA sequencing, together with pre-constructed...
#1Hyo Jeong Kang (UOU: University of Ulsan)H-Index: 15
#2Ji Hye Oh (UOU: University of Ulsan)
Last. Seung-Mo Hong (UOU: University of Ulsan)H-Index: 59
view all 12 authors...
BACKGROUND & AIMS Chromophobe hepatocellular carcinoma (HCC) is a newly included subtype of HCC in the 5th edition of the WHO classification with distinctive histological features (chromophobic cytoplasm with anaplastic nuclei and pseudocyst formation) and is strongly associated with the alternative lengthening of telomeres (ALT) phenotype. However, the clinicopathologic characterization and molecular features of chromophobe HCC are unknown. METHODS To comprehensively characterize chromophobe HC...
#1Hyo Jung Park (UOU: University of Ulsan)H-Index: 10
#2Jae Ho Byun (UOU: University of Ulsan)H-Index: 28
Last. Pyo Nyun Kim (UOU: University of Ulsan)H-Index: 52
view all 10 authors...
Abstract Purpose To identify the value of discrepancies in the central scar (CS)-like structure between dynamic CT and gadoxetate disodium-enhanced MRI for differentiating FNH from HCA. Methods This retrospective study included 113 patients with pathologically-diagnosed FNH (n = 80) or HCA (n = 37). CS-like structures were evaluated on arterial phase (AP) CT and hepatobiliary phase (HBP) MRI. Presence of the CS-like structure, its discrepancy in visibility or size between AP CT and HBP MRI and b...
#1Hee Sang Hwang (UOU: University of Ulsan)H-Index: 7
#2Jihyun An (Hanyang University)H-Index: 17
Last. Eunsil Yu (UOU: University of Ulsan)H-Index: 32
view all 10 authors...
BACKGROUND Although hepatocellular carcinomas (HCCs) often recur in patients undergoing hepatectomy, there are no reliable biomarkers of this undesirable event. Recent RNA-based efforts have developed valuable genetic indices prognostic of cancer outcomes. We aimed to identify molecular predictors of early recurrence after resection of HCC, and reveal the genomolecular structure of the resected tumors. METHOD Based on the transcriptomic and genomic datasets of 206 HCC samples surgically resected...
1 CitationsSource
#8Chang-Hee Lee (KU: Korea University)H-Index: 31
Hypointense nodules without arterial hyperenhancement at gadoxetic acid–enhanced MRI correspond to hepatocellular carcinoma or premalignant hepatocellular nodules.
6 CitationsSource
#1Jung Hee Son (UOU: University of Ulsan)H-Index: 3
#2Seung Soo Lee (UOU: University of Ulsan)H-Index: 31
Last. Eunsil Yu (UOU: University of Ulsan)H-Index: 32
view all 7 authors...
OBJECTIVES: To evaluate whether the liver and spleen volumetric indices, measured on portal venous phase CT images, could be used to assess liver fibrosis severity in chronic liver disease. METHODS: From 2007 to 2017, 558 patients (mean age 48.7 +/- 13.1 years; 284 men and 274 women) with chronic liver disease (n = 513) or healthy liver (n = 45) were retrospectively enrolled. The liver volume (sVolL) and spleen volume (sVolS), normalized to body surface area and liver-to-spleen volume ratio (Vol...
13 CitationsSource
#1Baek-Hui Kim (KU: Korea University)H-Index: 8
#2Joon Mee Kim (Inha University)H-Index: 21
Last. Youn Wha KimH-Index: 22
view all 24 authors...
The first edition of the 'Standardized Pathology Report for Colorectal Cancer,' which was developed by the Gastrointestinal Pathology Study Group (GIP) of the Korean Society of Pathologists, was published 13 years ago. Meanwhile, there have been many changes in the pathologic diagnosis of colorectal cancer (CRC), pathologic findings included in the pathology report, and immunohistochemical and molecular pathology required for the diagnosis and treatment of colorectal cancer. In order to reflect ...
8 CitationsSource
#1Sunyoung Lee (UOU: University of Ulsan)H-Index: 17
#2Kyoung Won Kim (UOU: University of Ulsan)H-Index: 42
Last. Kee-Taek Jang (SMC: Samsung Medical Center)H-Index: 31
view all 5 authors...
Biliary adenofibroma is a rare tumor with a bile duct origin characterized by a complex tubulocystic non-mucin secreting biliary epithelium with abundant fibrous stroma. The MRI features of biliary adenofibroma are not well established. The authors encountered two patients with biliary adenofibroma and reviewed the literature focusing on the MRI findings. A well-circumscribed multicystic tumor with septal enhancement and no intrahepatic bile duct communication may be the characteristic MRI findi...
1 CitationsSource
#1Hyo Jeong Kang (UOU: University of Ulsan)H-Index: 15
#2Ji-Hye Oh (UOU: University of Ulsan)H-Index: 3
Last. Eunsil Yu (UOU: University of Ulsan)H-Index: 32
view all 13 authors...
Background & aims The immunogenomic characteristics of hepatocellular carcinomas (HCCs) with immune cell stroma (HCC-IS), defined histologically, have not been clarified. We investigated the clinical and molecular features of HCC-IS and the prognostic impact of Epstein-Barr virus (EBV) infection. Methods We evaluated 219 patients with conventional HCC (C-HCC) and 47 with HCC-IS using in situ hybridization for EBV, immunohistochemistry, multiplex immunofluorescence staining, and whole exome and t...
15 CitationsSource
#1Hyo Jeong Kang (UOU: University of Ulsan)H-Index: 15
#2Soon Auck Hong (SCH: Soonchunhyang University)H-Index: 10
Last. Eunsil Yu (UOU: University of Ulsan)H-Index: 32
view all 7 authors...
BACKGROUND: Progressive familial intrahepatic cholestasis (PFIC) is a heterogeneous group of autosomal recessive liver diseases that present as neonatal cholestasis. Little is known of this disease in Korea. METHODS: The records of five patients histologically diagnosed with PFIC, one with PFIC1 and four with PFIC2, by liver biopsy or transplant were reviewed, and ATP8B1 and ABCB11 mutation status was analyzed by direct DNA sequencing. Clinicopathological characteristics were correlated with gen...
4 CitationsSource