Alessia Pascale
University of Pavia
Messenger RNAPhosphorylationInternal medicineEndocrinologyGene expressionMolecular biologyNeuroscienceKinaseChemistryProtein kinase CImmunologyDiseaseDiabetic retinopathyRetinalRNA-binding proteinBiochemistryMedicineBiologyCell biology
129Publications
36H-index
3,327Citations
Publications 132
Newest
#1Foroogh Fahmideh (UNIPV: University of Pavia)H-Index: 3
#2Nicoletta Marchesi (UNIPV: University of Pavia)H-Index: 13
Last. Alessia Pascale (UNIPV: University of Pavia)H-Index: 36
view all 5 authors...
Glaucoma is a major ocular neurodegenerative disease characterized by progressive retinal ganglion cells degeneration and sight loss. Current treatment options have been limited to reducing intraocular pressure (IOP), known as the leading risk factor for this disease; however, glaucoma can develop even with low or normal IOP and progress despite controlling IOP values. Lifestyle, dietary habits, and supplementation may influence some of the risk factors and pathophysiological mechanisms underlyi...
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#1Nicoletta MarchesiH-Index: 13
#2Foroogh FahmidehH-Index: 3
Last. Annalisa BarbieriH-Index: 10
view all 5 authors...
The possible interconnection between the eye and central nervous system (CNS) has been a topic of discussion for several years just based on fact that the eye is properly considered an extension of the brain. Both organs consist of neurons and derived from a neural tube. The visual process involves photoreceptors that receive light stimulus from the external environment and send it to retinal ganglionic cells (RGC), one of the cell types of which the retina is composed. The retina, the internal ...
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#1Claudio BucoloH-Index: 46
#2Annalisa BarbieriH-Index: 10
Last. Alessia PascaleH-Index: 36
view all 0 authors...
To investigate the role of VEGF at different phases of diabetic retinopathy (DR), we assessed the retinal protein expression of VEGF, HIF-1α and PKCβ/HuR pathway in Ins2Akita (diabetic) mice at different ages. We used C57BL6J mice (WT) at different ages as control. Retina status, in terms of tissue morphology and neovascularization, was monitored in vivo at different time points by optical coherence tomography (OCT) and fluorescein angiography (FA), respectively. The results showed that VEGF pro...
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#2Adriana CoricelloH-Index: 5
Last. Francesca Vasile (University of Milan)H-Index: 15
view all 12 authors...
ELAV-like (ELAVL) RNA-binding proteins play a pivotal role in post-transcriptional processes, and their dysregulation is involved in several pathologies. This work was focused on HuD (ELAVL4), which is specifically expressed in nervous tissues, and involved in differentiation and synaptic plasticity mechanisms. HuD represents a new, albeit unexplored, candidate target for the treatment of several relevant neurodegenerative diseases. The aim of this pioneering work was the identification of new m...
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#1Nicoletta Marchesi (UNIPV: University of Pavia)H-Index: 13
#2Annalisa Barbieri (UNIPV: University of Pavia)H-Index: 10
Last. Laura CalvilloH-Index: 16
view all 9 authors...
Chronic conditions requiring long-term rehabilitation therapies, such as hypertension, stroke, or cancer, involve complex interactions between various systems/organs of the body and mutual influences, thus implicating a multiorgan approach. The dual-flow IVTech LiveBox2 bioreactor is a recently developed inter-connected dynamic cell culture model able to mimic organ crosstalk, since cells belonging to different organs can be connected and grown under flow conditions in a more physiological envir...
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#1Alessia Pascale (UNIPV: University of Pavia)H-Index: 36
#2Nicoletta Marchesi (UNIPV: University of Pavia)H-Index: 13
Last. Annalisa Barbieri (UNIPV: University of Pavia)H-Index: 10
view all 4 authors...
Abstract There is increasing interest in the role of the gut microbiota in health and disease. In particular, gut microbiota influences the Central Nervous System (CNS) development and homeostasis through neural pathways or routes involving the immune and circulatory systems. The CNS, in turn, shapes the intestinal flora through endocrine or stress-mediated responses. These overall bidirectional interactions, known as gut microbiota-brain axis, profoundly affect some brain functions, such as neu...
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#1Chiara Bianca Maria Platania (University of Catania)H-Index: 20
#2Valeria Pittalà (University of Catania)H-Index: 29
Last. Claudio Bucolo (University of Catania)H-Index: 46
view all 10 authors...
#1Chiara Bianca Maria Platania (University of Catania)H-Index: 20
#2Valeria Pittalà (University of Catania)H-Index: 29
Last. Claudio Bucolo (University of Catania)H-Index: 46
view all 12 authors...
The ELAVL1 (or human antigen R with an AU-rich element, of several genes such as growth factors (i.e. VEGF) and inflammatory cytokines (i.e. TNFalpha). We hereby carried out a virtual screening campaign in order to identify and test novel HuR-mRNA disruptors. Best-scored compounds were tested in an in-vitro model of diabetic retinopathy, namely human retinal endothelial cells (HRECs) challenged with high-glucose levels (25 mM). HuR, VEGF and TNFalpha protein contents were evaluated by western-bl...
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Objectives: Objective: The aim of this study is to describe the epidemiological surveillance of Carbapenem-Resistant Enterobacteriaceae (CRE) effected at the Neurological Hospital Carlo Besta, Milano, Italy. The primary causes in our division of multidrug-resistant (MDRs) infections in 2016 were K. pneumoniae and A. baumannii; the preventive actions have ensured the reduction of their incidence in 2017 and allowed us to discover the microbiological sentinel events (SE) and start appropriate prec...
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#1Cristiana Pistono (UNIPV: University of Pavia)H-Index: 4
#2Maria Cristina Monti (UNIPV: University of Pavia)H-Index: 16
Last. Alessia Pascale (UNIPV: University of Pavia)H-Index: 36
view all 12 authors...
ABSTRACT Background ELAV-like proteins are a small family of RNA-binding proteins that are fundamental players in post-transcriptional mechanisms and are involved in the pathogenesis of neurologic and psychiatric disorders. HuR, the ubiquitously expressed member of the family, is also implicated in sustaining inflammation and inflammatory diseases, supporting the production of pro-inflammatory cytokines. Inflammation plays a central role in Multiple Sclerosis (MS), which represents the most comm...
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