Yuanjin Xu
Shanghai Jiao Tong University
OsteocalcinBiomedical engineeringAlkaline phosphataseStromal cellKinaseChemistryMaterials scienceMesenchymal stem cellVascular endothelial growth factorBone marrowNano-AngiogenesisIcariinBioceramicBone regenerationMAPK/ERK pathwaySignal transductionMedicineOvariectomized ratCell biology
19Publications
12H-index
768Citations
Publications 19
Newest
#1Lu Liu (SJTU: Shanghai Jiao Tong University)H-Index: 4
#2Fei Yu (SJTU: Shanghai Jiao Tong University)H-Index: 29
Last. Lunguo Xia (SJTU: Shanghai Jiao Tong University)H-Index: 29
view all 9 authors...
Abstract Dual-functional regulation for angiogenesis and osteogenesis is crucial for desired bone regeneration especially in large-sized bone defects. Exosomes have been demonstrated to facilitate bone regeneration through enhanced osteogenesis and angiogenesis. Moreover, functional stimulation to mesenchymal stromal cells (MSCs) was reported to further boost the pro-angiogenic ability of exosomes secreted. However, whether the stimulation by bioactive trace elements of biomaterials could enhanc...
2 CitationsSource
#1Yue Hu (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Zhipeng Gui (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Yuanjin Xu (SJTU: Shanghai Jiao Tong University)H-Index: 12
view all 6 authors...
Abstract Osteoarthritis (OA) is a progressive joint disorder that is primarily characterized by the degeneration and destruction of the articular cartilage. Cartilage matrix degradation, production of proinflammatory mediators, chondrocyte apoptosis and activation of macrophages in the synovial are involved in OA pathogenesis. Current non-surgical therapies for OA mainly aim at relieving pain but can barely alleviate the progression of OA. Quercetin, a naturally occurring flavonoid has shown pot...
23 CitationsSource
#1Lunguo Xia (SJTU: Shanghai Jiao Tong University)H-Index: 29
#2Wudi Ma (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last. Yuanjin Xu (SJTU: Shanghai Jiao Tong University)H-Index: 12
view all 10 authors...
Polycaprolactone (PCL) has attracted great attention for bone regeneration attributed to its cost-efficiency, high toughness, and good processability. However, the relatively low elastic modulus, hydrophobic nature, and insufficient bioactivity of pure PCL limited its wider application for bone regeneration. In the present study, the effects of the addition of boron containing bioactive glass (B-BG) materials on the mechanical properties and biological performance of PCL polymer were investigate...
6 CitationsSource
#1Wenjun Sun (Tongji University)H-Index: 2
#2Yuning Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 8
Last. Kaili Lin (Tongji University)H-Index: 8
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Abstract Injectable bioactive ceramics with excellent osteogenesis play important roles in bone regeneration field. In this study, we creatively fabricated the injectable nano-structured silicon-containing hydroxyapatite (Si-HAp) microspheres in diameter of 70–100 µm via hydrothermal treatment of calcium silicate (CaSiO3) microspheres in Na3PO4 aqueous solution. The fabricated Si-HAp microspheres were constructed by nano-rods with a diameter of 100 nm and length up to 1.5 µm. Comparing with the ...
7 CitationsSource
#1Yuqiong Wu (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Lingyan Cao (SJTU: Shanghai Jiao Tong University)H-Index: 9
Last. Xinquan Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 52
view all 10 authors...
Typically, bone regenerative medicine is applied to repair bone defects in patients with osteoporosis. Meanwhile, there is an urgent need to develop safe and cheap drugs that induce bone formation. Icariin, which is reported to promote the osteogenesis of stem cells in vitro, is the main active component of Herba Epimedii. However, whether icariin could repair bone defects caused by osteoporosis remains unknown. In this study, an osteoporosis model in rats was established by an ovariectomy first...
27 CitationsSource
#1Yuning Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Yuqiong Wu (SJTU: Shanghai Jiao Tong University)H-Index: 5
Last. Yuanjin Xu (SJTU: Shanghai Jiao Tong University)H-Index: 12
view all 9 authors...
Bone regeneration under osteoporotic conditions with impaired angiogenesis, osteogenesis and remodeling represents a great challenge. In the present study, the effects of quercetin on proliferation, osteogenic differentiation and angiogenic factor secretion as well as on the osteoclastogenic factor secretion of ovariectomized (OVX) rat bone marrow-derived mesenchymal stem cells (rBMSCs) were first evaluated in vitro. The role of mitogen-activated protein kinase (MAPK) signaling pathways and the ...
12 CitationsSource
#1Yuqiong Wu (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Lunguo Xia (SJTU: Shanghai Jiao Tong University)H-Index: 29
Last. Xinquan Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 52
view all 9 authors...
Icariin has been identified to promote osteogenic differentiation of bone mesenchymal stem cells (BMSCs). However, whether icariin could enhance angiogenic factor expression of BMSCs, which may be vital for bone repair, needs to be explored. Moreover, how to construct a delivery system of icariin and its repair capability in bone defects are still unknown. In the present study, the effects of icariin on the osteogenic differentiation and angiogenic factor expression of BMSCs were firstly evaluat...
18 CitationsSource
#1Yuning Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 8
#2Yuqiong Wu (SJTU: Shanghai Jiao Tong University)H-Index: 5
Last. Yuanjin Xu (SJTU: Shanghai Jiao Tong University)H-Index: 12
view all 7 authors...
Bone marrow-derived mesenchymal stem cells (BMSCs) are widely used in regenerative medicine in light of their ability to differentiate along the chondrogenic and osteogenic lineages. As a type of traditional Chinese medicine, quercetin has been preliminarily reported to promote osteogenic differentiation in osteoblasts. In the present study, the effects of quercetin on the proliferation, viability, cellular morphology, osteogenic differentiation and angiogenic factor secretion of rat BMSCs (rBMS...
56 CitationsSource
#1Yuqiong Wu (SJTU: Shanghai Jiao Tong University)H-Index: 5
#2Lunguo Xia (SJTU: Shanghai Jiao Tong University)H-Index: 29
Last. Xinquan Jiang (SJTU: Shanghai Jiao Tong University)H-Index: 52
view all 5 authors...
Objectives Icariin, a flavonoid isolated from Epimedium pubescens, has previously been identified to exert beneficial effects on preventing bone loss and promoting bone regeneration. However, molecular mechanisms for its anabolic action have, up to now, remained largely unknown. Materials and methods Effects of icariin on cell proliferation and osteogenic differentiation of rat bone mesenchymal stem cells (BMSCs) were systematically evaluated. To characterize underlying mechanisms, its effects o...
65 CitationsSource
#1Xiuhui Wang (CAS: Chinese Academy of Sciences)H-Index: 6
#2Yuning Zhou (SJTU: Shanghai Jiao Tong University)H-Index: 8
Last. Kaili Lin (CAS: Chinese Academy of Sciences)H-Index: 51
view all 13 authors...
Abstract The bioactivity and stability of coatings on alloy implants play critical roles in the fast osseointegration and maintenance of a long-term life span of the implants, respectively. Herein, nano-sheet surface on bioactive calcium silicate (CaSiO 3 , CS) coatings on metal substrates was fabricated by combining atmosphere plasma spraying (APS) and hydrothermal technology (HT). The glassy phase in CS coatings generated by APS was converted into crystalline sheet-like nano-structures after H...
42 CitationsSource