Hanlin L. Wang
University of California, Los Angeles
CancerInternal medicinePathologyImmunologyImmunohistochemistryBiopsyCarcinomaLiver biopsyHepatocellular carcinomaInflammatory bowel diseaseMetastasisGastrointestinal tractAdenocarcinomaImmunostainingCancer researchColorectal cancerMedicineStainingBiologyGastroenterology
135Publications
42H-index
4,713Citations
Publications 133
Newest
#1Yejoo Jeon (UCLA: University of California, Los Angeles)
#2David Leung (Scripps Mercy Hospital)
Last. Jonathan D. Kaunitz (UCLA: University of California, Los Angeles)H-Index: 36
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#1Lifang FanH-Index: 13
Last. Hanlin L. Wang (UCLA: University of California, Los Angeles)H-Index: 42
view all 8 authors...
GOAL We aimed to study the density of intramucosal mast cells in histologically normal colonic mucosa biopsied from patients with a clinical diagnosis of irritable bowel syndrome (IBS). BACKGROUND Mast cell activation has been thought to implicate in the pathogenesis of inflammatory bowel disease (IBD). Whether it serves a role in the pathogenesis of IBS remains controversial. STUDY A total of 127 colonoscopic mucosal biopsies were immunohistochemically stained, including 51 IBS, 66 IBD, and 10 ...
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#1Joon Park (UCLA: University of California, Los Angeles)H-Index: 5
#2Jonathan C. King (UCLA: University of California, Los Angeles)H-Index: 16
Last. Mark D. Girgis (UCLA: University of California, Los Angeles)H-Index: 13
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BACKGROUND AND OBJECTIVES: This study investigated the influence of the transcription factor SMAD4 on overall patient survival following surgical resection of pancreatic ductal adenocarcinoma (PDAC). METHODS: The SMAD4 status of 125 surgically resected PDAC specimens at a large academic center from 2014 to 2017 was routinely determined prospectively and correlated with clinicopathologic characteristics and overall survival. RESULTS: SMAD4 loss was identified in 62% of patients and was not associ...
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#1Yuan Li (UCLA: University of California, Los Angeles)H-Index: 1
#2Fangfang Liu (PKU: Peking University)
Last. Hanlin L. Wang (UCLA: University of California, Los Angeles)H-Index: 42
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Histologic distinction between well differentiated hepatocellular carcinoma (HCC) and benign hepatocellular mass lesions is a known challenge. Existing biomarkers are of limited diagnostic value. Our previous studies observed an enhanced canalicular expression pattern of clusterin (CLU) in HCC, which was not observed in benign hepatocellular mass lesions such as hepatocellular adenoma. The aim of this study was to further investigate its diagnostic value for HCC by examining the expression patte...
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#1Yingying YangH-Index: 1
#2J. R. Hecht (UCLA: University of California, Los Angeles)H-Index: 13
Last. Anthony P. HeaneyH-Index: 33
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ABSTRACT Objective: Immune checkpoint inhibitors are approved to treat multiple cancers. We report life-threatening hepatic failure in 2 consecutive patients with Cushing syndrome that were treated...
1 CitationsSource
Objective For many patients whose pancreatic ductal adenocarcinoma (PDAC) is locally advanced, neoadjuvant therapy has been proposed as a way to decrease tumor burden. Pancreatic ductal adenocarcinoma is generally thought to be resistant to chemotherapy and radiation, however, response to neoadjuvant therapy in PDAC has been described in a subset of patients. The SMAD4 status is considered to be an important molecular feature which distinguishes two subsets of PDAC, SMAD4-positive and -negative ...
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#1Yuan Li (UCLA: University of California, Los Angeles)H-Index: 1
#2Pouneh BeizaiH-Index: 1
Last. Hanlin L. Wang (UCLA: University of California, Los Angeles)H-Index: 42
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Abstract Mucosal Schwann cell hamartoma (MSCH) is an uncommon neural lesion characterized by an ill-defined proliferation of S100-positive Schwann cells in the lamina propria, with reported cases exclusively occurring in the colorectum. Here we describe the first series of MSCHs arising in the gastroesophageal junction (GEJ) and discuss their clinicopathologic features in comparison with their colorectal counterparts. We searched the UCLA pathology database from 01/2014 to 12/2018 to identify ca...
1 CitationsSource
#1Lindsay Alpert (U of C: University of Chicago)H-Index: 9
#2Ram Al-Sabti (U of C: University of Chicago)H-Index: 1
Last. Mary P. Bronner (UofU: University of Utah)H-Index: 70
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Smooth muscle tumors represent the second most common mural mesenchymal neoplasm in the gastrointestinal tract, but established criteria for prognostic assessment of these tumors are lacking. A large cohort of surgically resected intramural gastrointestinal smooth muscle tumors from 31 institutions was analyzed to identify potential prognostic features. Pathologic features were assessed by expert gastrointestinal and/or soft tissue pathologists at each center. Immunohistochemical confirmation wa...
3 CitationsSource
: Histopathologic diagnosis of antibody-mediated rejection in posttransplant liver biopsies is challenging. The recently proposed diagnostic criteria by the Banff Working Group on Liver Allograft Pathology require positive C4d immunohistochemical staining to establish the diagnosis. However, the reported C4d staining patterns vary widely in different studies. One potential explanation may be due to different antibody preparations used by different investigators. In this study, posttransplant liv...
1 CitationsSource
#1Rish K. PaiH-Index: 30
#2David E. KleinerH-Index: 117
Last. Vipul JairathH-Index: 20
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Background There is substantial variation in how histologic definitions and scoring systems of non-alcoholic fatty liver disease (NAFLD) are operationalised. Aim To develop a consensus-based framework for standardising histologic assessment of liver biopsies in clinical trials of NAFLD. Methods An expert panel of 14 liver pathologists and three hepatologists was assembled. Using modified RAND/University of California Los Angeles appropriateness methodology, 130 items derived from literature revi...
10 CitationsSource