Matthew J. Weiss
Johns Hopkins University School of Medicine
CancerInternal medicineRadiologySurgeryOncologyResectionRetrospective cohort studySurvival rateChemotherapyHepatectomyPancreatectomyPancreasMetastasisPancreatic cancerAdenocarcinomaIntrahepatic CholangiocarcinomaIn patientGeneral surgeryMedicineGastroenterology
403Publications
48H-index
6,799Citations
Publications 402
Newest
#1Georgios Gemenetzis (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 17
#2Alex B. Blair (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 17
Last. Matthew J. Weiss (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 48
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BACKGROUND The introduction of multi-agent chemotherapy and radiation therapy has facilitated potential resection with curative intent in selected locally advanced pancreatic cancer (LAPC) patients with excellent outcomes. Nevertheless, there remains a remarkable lack of consensus on the management of LAPC. We sought to describe the outcomes of patients with LAPC and objectively define the multidisciplinary selection process for operative exploration based on anatomical factors. METHODS Consecut...
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#1Won Jin Ho (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 10
#2Qingfeng Zhu (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 13
Last. Nicole Gross (JHUSOM: Johns Hopkins University School of Medicine)
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A potentially curative hepatic resection is the optimal treatment for hepatocellular carcinoma (HCC) but most patients are not candidates for resection and most resected HCCs eventually recur. Until recently, neoadjuvant systemic therapy for HCC has been limited by a lack of effective systemic agents. Here, in a single-arm phase 1b study, we evaluated the feasibility of neoadjuvant cabozantinib and nivolumab in patients with HCC, including patients outside of traditional resection criteria (Clin...
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#1Alex B. Blair (Johns Hopkins University)H-Index: 17
#2Ling Di Yin (JHUSOM: Johns Hopkins University School of Medicine)
Last. Jin He (Johns Hopkins University)H-Index: 40
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OBJECTIVE: The aim of this study was to characterize the patterns and treatment of disease recurrence in patients achieving a pathological complete response (pCR) following neoadjuvant chemoradiation for advanced pancreatic ductal adenocarcinoma (PDAC). SUMMARY OF BACKGROUND DATA: A pCR is an independent predictor for improved survival in PDAC. However, disease recurrence is still observed in these patients. METHODS: Patients with advanced PDAC who were treated with neoadjuvant therapy and had a...
6 CitationsSource
#1Ling LiH-Index: 8
#2Gilad Halpert (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 8
Last. Florin M. Selaru (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 40
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Hepatocellular carcinoma (HCC) is the 6th-most common and the 4th-most deadly cancer worldwide. The development cost of new therapeutics is a major limitation in patient outcomes. Importantly, there is a paucity of preclinical HCC models in which to test new small molecules. Herein, we implemented novel patient-derived organoid (PDO) and patient-derived xenografts (PDX) strategies for high-throughput drug screening. Omacetaxine, an FDA-approved drug for chronic myelogenous leukemia (CML), was fo...
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#1Georgios A. Margonis (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 7
#2Neda Amini (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 27
Last. Matthew J. Weiss (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 48
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Objective:To examine the prognostic impact of tumor laterality in colon cancer liver metastases (CLM) after stratifying by Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) mutational status.Background:Although some studies have demonstrated that patients with CLM from a right sided (RS) primary c
11 CitationsSource
#1Bradley N. Reames (UNMC: University of Nebraska Medical Center)H-Index: 19
#1Bradley N. Reames (UNMC: University of Nebraska Medical Center)H-Index: 2
Last. Jin He (Johns Hopkins University)H-Index: 40
view all 12 authors...
MiniAn international survey of high-volume pancreas cancer surgeons revealed wide variations in management preferences, attitudes regarding contraindications to surgery, and the propensity to offer exploration. When presented with 6 hypothetical clinical vignettes using details from real patients th
18 CitationsSource
#1Alex B. Blair (Johns Hopkins University)H-Index: 17
#2Robert W. KrellH-Index: 17
Last. Bradley N. Reames (UNMC: University of Nebraska Medical Center)H-Index: 3
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BACKGROUND AND PURPOSE There is limited high-level evidence to guide locally advanced pancreas cancer (LAPC) management. Recent work shows that surgeons' preferences in LAPC management vary broadly. We sought to examine whether surgeon volume was associated with attitudes regarding LAPC management. METHODS An electronic survey was distributed by email to an international cohort of pancreas surgeons to evaluate practice patterns regarding LAPC management. Clinical vignette-based questions evaluat...
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#1Andrew R. Kolarich (JHUSOM: Johns Hopkins University School of Medicine)
#2Alex J Solomon (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 2
Last. Kelvin Hong (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 29
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PURPOSE To identify perioperative factors that are significantly associated with complications requiring interventional radiology (IR) treatment after hepatectomy. METHODS We retrospectively reviewed data from 11,243 patients in the USA who underwent hepatectomy from 2014 to 2016 using the National Surgical Quality Improvement Program database. Data on the following IR procedures were extracted: abscess drain placement, endovascular treatment for bleeding, and postoperative percutaneous biliary ...
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#1Diamantis I. Tsilimigras (The Ohio State University Wexner Medical Center)H-Index: 21
#2Kota Sahara (The Ohio State University Wexner Medical Center)H-Index: 15
Last. Timothy M. Pawlik (The Ohio State University Wexner Medical Center)H-Index: 118
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BACKGROUND The objective of the current study was to develop a model to predict the likelihood of occult lymph node metastasis (LNM) prior to resection of intrahepatic cholangiocarcinoma (ICC). METHODS Patients who underwent hepatectomy for ICC between 2000 and 2017 were identified using a multi-institutional database. A novel model incorporating clinical and preoperative imaging data was developed to predict LNM. RESULTS Among 980 patients who underwent resection of ICC, 190 (19.4%) individuals...
1 CitationsSource
#2Madison HyerH-Index: 5
Last. Timothy M. PawlikH-Index: 118
view all 18 authors...
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