Charles J. Yeo
Thomas Jefferson University Hospital
CancerInternal medicineEndocrinologySurgeryPathologyOncologyPancreatitisPancreatic diseasePancreatectomyPancreasPancreaticoduodenectomyPancreatic cancerPancreatic fistulaAdenocarcinomaPerioperativeCancer researchGeneral surgeryMedicineBiologyGastroenterology
Publications 805
#1Christopher W. Schultz (Thomas Jefferson University)H-Index: 5
#2Grace A. McCarthy (OHSU: Oregon Health & Science University)H-Index: 1
Last. Aditi Jain (Thomas Jefferson University)H-Index: 7
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Pancreatic Ductal Adenocarcinoma (PDAC) is a lethal aggressive cancer, in part due to elements of the microenvironment (hypoxia, hypoglycemia) that cause metabolic network alterations. The FDA approved anti-helminthic Pyrvinium Pamoate (PP) has been previously shown to cause PDAC cell death, although the mechanism has not been fully determined. We demonstrated that PP effectively inhibited PDAC cell viability with nanomolar IC50s (9-93nM) against a panel of PDAC, patient-derived, and murine orga...
#1Marisa A. Joel (Thomas Jefferson University)
#2Kris R. Kaulback (Thomas Jefferson University)H-Index: 5
Last. Joshua A. Marks (Thomas Jefferson University)H-Index: 9
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Abstract null null Background null The Surgeon General oversees the Commissioned Corps of the U.S. Public Health Service (USPHS) and is viewed as the “Nation’s Doctor,” responsible for providing the public with information on living healthier and safer lives. The Surgeon General’s influence is seen through public health initiatives such as warning labels on tobacco and alcohol products. null The objectives of this paper are to describe the tradition of the Office of the Surgeon General as create...
#1Nikolaos MachairasH-Index: 2
#2Dimitri A. RaptisH-Index: 32
Last. Charles J. YeoH-Index: 155
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OBJECTIVE The aim of this study was to evaluate whether neoadjuvant therapy (NAT) critically influenced microscopically complete resection (R0) rates and long-term outcomes for patients with pancreatic ductal adenocarcinoma who underwent pancreatoduodenectomy (PD) with portomesenteric vein resection (PVR) from a diverse, world-wide group of high-volume centers. SUMMARY BACKGROUND DATA Limited size studies suggest that NAT improves R0 rates and overall survival compared to upfront surgery in rese...
#1Theresa P. Yeo (Thomas Jefferson University)H-Index: 7
Last. Charles J. YeoH-Index: 155
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Objective null The objective of this study was to determine baseline health-related quality of life (QoL) in patients with pancreatic adenocarcinoma (PA), peri-ampullary cancers, and benign pancreaticobiliary (PB) conditions at the time of the first visit to a PB surgery clinic, and to explore the relationship between QoL, demographics, clinical parameters, complications and survival. null Summary background data null Few studies have examined baseline QoL measures, the impact of co-morbidities,...
#1Teena Nerwal (Thomas Jefferson University Hospital)
#2Austin Goetz (Thomas Jefferson University Hospital)H-Index: 1
Last. Kim HooKim (Thomas Jefferson University Hospital)H-Index: 9
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Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) is the preferred method for diagnosing pancreatic masses. While the diagnostic success of EUS-FNA is widely accepted, the actual performance of EUS-FNA is not known. This study sought to define the EUS-FNA accuracy compared with the gold standard, surgically resected specimens. The study was a single institution, retrospective, and chart review of patients with surgically resected pancreatic specimens from 2005 to 2015 with a preopera...
1 CitationsSource
#1Elwin ThamH-Index: 2
Last. Harish LavuH-Index: 19
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#1Amy McGhee-Jez (Thomas Jefferson University Hospital)H-Index: 1
#2Inna Chervoneva (Thomas Jefferson University)H-Index: 33
Last. Atrayee Basu Mallick (Thomas Jefferson University Hospital)H-Index: 2
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Purpose: Current literature reports increased incidence of postpancreaticoduodenectomy (PD) nonalcoholic fatty liver disease (NAFLD), a precursor for nonalcoholic steatohepatitis and cirrhosis. The...
#1Robert A. Ries (Thomas Jefferson University Hospital)
#2Christina L. Jacovides (UPenn: University of Pennsylvania)H-Index: 3
Last. Charles J. Yeo (Thomas Jefferson University Hospital)H-Index: 155
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Background: Both primary pancreatic lymphoma (PPL) and primary splenic lymphoma (PSL) represent rare entities. PPL typically arises in the head of the pancreas but may arise in other locations also...
#1Richard Zheng (Thomas Jefferson University)H-Index: 4
#2David Nauheim (Thomas Jefferson University)H-Index: 2
Last. Adam C. Berger (RU: Rutgers University)H-Index: 50
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The impact of resecting positive margins during pancreaticoduodenectomy (PD) for pancreatic ductal adenocarcinoma (PDA) remains debated. Additionally, the survival benefit of resecting multiple positive margins is unknown. We identified patients with PDA who underwent PD from 2006 to 2015. Pancreatic neck, bile duct, and uncinate frozen section margins were assessed before and after resection of positive margins. Survival curves were compared with log-rank tests. Multivariable Cox regression ass...
3 CitationsSource