Ashok K. Kakkar
McGill University
NanoparticleNanotechnologyOrganic chemistryNanocarriersChemistryPolymer chemistryThin filmChromophoreMaterials scienceMacromoleculeCombinatorial chemistryDrug deliveryMoleculeChemical engineeringPolymerDendrimerClick chemistryMonolayerStereochemistryCrystallography
151Publications
43H-index
3,899Citations
Publications 147
Newest
#1Hui Wen Yong (McGill University)H-Index: 1
#2Ashok K. Kakkar (McGill University)H-Index: 43
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#1Davit Zargarian (UdeM: Université de Montréal)H-Index: 42
#2Stephen A. Westcott (MtA: Mount Allison University)H-Index: 32
Last. Ashok K. Kakkar (McGill University)H-Index: 43
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#1Evan Rizzel Gran (McGill University)H-Index: 3
#2Victor Lotocki (McGill University)H-Index: 3
Last. Dusica Maysinger (McGill University)H-Index: 63
view all 6 authors...
A fundamental problem in oncology is that anticancer chemotherapeutics kill both cancer and healthy cells in the surrounding tissues. Resveratrol is a natural antioxidant with intriguing and opposing biological properties: it reduces viability of some cancer cells but not of non-transformed ones (in equimolar concentrations). Therefore, we examined resveratrol in human non-transformed primary astrocytes and astrocytoma. Resveratrol reduced reactive oxygen species in astrocytes, but not in astroc...
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#1Hui Wen Yong (McGill University)H-Index: 1
#2Ashok K. Kakkar (McGill University)H-Index: 43
Soft nanoparticles continue to offer a promising platform for the encapsulation and controlled delivery of poorly water-soluble drugs and help enhance their bioavailability at targeted sites. Linear amphiphilic block copolymers are the most extensively investigated in formulating delivery vehicles. However, more recently, there has been increasing interest in utilizing branched macromolecules for nanomedicine, as these have been shown to lower critical micelle concentrations, form particles of s...
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#1Ashok K. Kakkar (McGill University)H-Index: 43
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#1Victor Lotocki (McGill University)H-Index: 3
#2Hossein Yazdani (Shahid Beheshti University)H-Index: 6
Last. Ashok K. Kakkar (McGill University)H-Index: 43
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Branched architectures with asymmetric polymeric arms provide an advantageous platform for the construction of tailored nanocarriers for therapeutic interventions. Simple and adaptable synthetic methodologies to amphiphilic miktoarm star polymers have been developed in which spatial location of reactive oxygen species (ROS) and glutathione (GSH) responsive entities is articulated to be on the corona shell surface or inside the core. The design of such architectures is facilitated through versati...
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#1Parinaz Sabourian (McGill University)H-Index: 3
#2Ghazaleh Yazdani (Sharif University of Technology)H-Index: 1
Last. Ashok K. Kakkar (McGill University)H-Index: 43
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Cellular internalization of inorganic, lipidic and polymeric nanoparticles is of great significance in the quest to develop effective formulations for the treatment of high morbidity rate diseases. Understanding nanoparticle-cell interactions plays a key role in therapeutic interventions, and it continues to be a topic of great interest to both chemists and biologists. The mechanistic evaluation of cellular uptake is quite complex and is continuously being aided by the design of nanocarriers wit...
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#1Dusica Maysinger (McGill University)H-Index: 63
#2Qiaochu Zhang (McGill University)H-Index: 1
Last. Ashok K. Kakkar (McGill University)H-Index: 43
view all 3 authors...
Nanostructured hyperbranched macromolecules have been extensively studied at the chemical, physical and morphological levels. The cellular structural and functional complexity of neural cells and their cross-talk have made it rather difficult to evaluate dendrimer effects in a mixed population of glial cells and neurons. Thus, we are at a relatively early stage of bench-to-bedside translation, and this is due mainly to the lack of data valuable for clinical investigations. It is only recently th...
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#1Søren Leth Mejlsøe (McGill University)H-Index: 2
#2Ashok K. Kakkar (McGill University)H-Index: 43
Architectural complexity has played a key role in enhancing the efficacy of nanocarriers for a variety of applications, including those in the biomedical field. With the continued evolution in designing macromolecules-based nanoparticles for drug delivery, the combination approach of using important features of linear polymers with dendrimers has offered an advantageous and viable platform. Such nanostructures, which are commonly referred to as telodendrimers, are hybrids of linear polymers cova...
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#1Victor Lotocki (McGill University)H-Index: 3
#2Ashok K. Kakkar (McGill University)H-Index: 43
Delivering active pharmaceutical agents to disease sites using soft polymeric nanoparticles continues to be a topical area of research. It is becoming increasingly evident that the composition of amphiphilic macromolecules plays a significant role in developing efficient nanoformulations. Branched architectures with asymmetric polymeric arms emanating from a central core junction have provided a pivotal venue to tailor their key parameters. The build-up of miktoarm stars offers vast polymer arm ...
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