Kentaro Fujii
Okayama University
Internal medicineRadiologyNeurosurgerySurgeryPathologyCellGene expressionIntegrinGlioblastomaVascular endothelial growth factorBevacizumabGliomaCilengitideAngiogenesisAnnexin A2Cancer researchText miningMedicineBiologyPharmacology
36Publications
8H-index
182Citations
Publications 37
Newest
#1Manabu Onishi (Okayama University)H-Index: 10
#2Kazuhiko Kurozumi (Okayama University)H-Index: 23
Last. Isao Date (Okayama University)H-Index: 58
view all 10 authors...
Cilengitide (EMD121974), an inhibitor of the adhesive function of integrins, demonstrated preclinical efficacy against malignant glioma. It is speculated that cilengitide can inhibit tumor growth, invasion, and angiogenesis. However, the effects of cilengitide on these processes have not been sufficiently examined. In this study, we investigated the anti-glioma effect of cilengitide using DNA microarray analysis. U87ΔEGFR cells (human malignant glioma cell line) were used for this experiment. Th...
10 CitationsSource
#1Manabu Onishi (Okayama University)H-Index: 10
#2Tomotsugu Ichikawa (Okayama University)H-Index: 22
Last. Isao Date (Okayama University)H-Index: 58
view all 10 authors...
Integrins are expressed in tumor cells and tumor endothelial cells, and likely play important roles in glioma angiogenesis and invasion. We investigated the anti-glioma mechanisms of cilengitide (EMD121974), an v3 integrin inhibitor, utilizing the novel invasive glioma models, J3T-1 and J3T-2. Immunohistochemical staining of cells in culture and brain tumors in rats revealed positive v3 integrin expression in J3T-2 cells and tumor endothelial cells, but not in J3T-1 cells. Established J3T-1 and ...
20 CitationsSource
#1Hazem J. AbuhusainH-Index: 4
Last. BK DeMastersH-Index: 1
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#1Satoshi Inoue (Okayama University)H-Index: 7
#2Tomotsugu Ichikawa (Okayama University)H-Index: 22
Last. Isao Date (Okayama University)H-Index: 58
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Objective Invasive behaviors of malignant gliomas are fundamental traits and major reasons for treatment failure. Delineation of invasive growth is important in establishing treatment for gliomas and experimental neuro-oncology could benefit from an invasive glioma model. In this study, we established two new cell line-based animal models of invasive glioma. Methods Two cell lines, J3T-1 and J3T-2, were derived from the same parental canine glioma cell line, J3T. These cells were inoculated to e...
23 CitationsSource
#1Fa H. Yang (JLU: Jilin University)H-Index: 1
#2Bo ZhangH-Index: 1
Last. Jun-ichiro Hamada (Kanazawa University)H-Index: 27
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Ginsenoside Rg3 is a natural active ingredient that is extracted from Korean red ginseng root. It elevates the therapeutic effect of radiotherapy and chemotherapy, but previous studies found that the application of Rg3 is heavily limited by its low bioavailability and poor absorption via oral administration. To overcome these problems, Rg3-loaded PEG-PLGA-NPs (Rg3-NPs) were prepared by the modified spontaneous emulsification solvent diffusion (SESD) method, and the physicochemical characteristic...
3 CitationsSource
#1Kazuhiko Kurozumi (Okayama University)H-Index: 23
#2Tomotsugu Ichikawa (Okayama University)H-Index: 22
Last. Isao Date (Okayama University)H-Index: 58
view all 5 authors...
Malignant glioma is the most common primary brain tumor and accounts for the majority of diagnoses. Treatment has involved a combination of surgery, radiation, and chemotherapy, yet these modalities rarely extend the life of the patient to more than one year from diagnosis. Integrins are expressed in tumor cells and tumor endothelial cells, and are important in angiogenesis and invasion in glioma. avb 3a ndavb5 integrins regulate cell adhesion, and inhibitors of these integrins suppress tumor gr...
38 CitationsSource
#1Hazem J. Abuhusain (UNSW: University of New South Wales)H-Index: 4
#2Azadeh Matin (UNSW: University of New South Wales)H-Index: 1
Last. Allen Waziri (Columbia University)H-Index: 23
view all 236 authors...
1 CitationsSource