Utako Fujii
Okayama University
Internal medicineRetinoid X receptorChemokineEndocrinologyPulmonary compliancePathologyInterleukin 23ReceptorImmunologyClinical endpointRetinoidPancreatic elastaseLungNeutrophiliaBronchoalveolar lavageRAGE (receptor)CytokineElastaseInnate lymphoid cellPartial agonistNuclear receptorMedicineInterleukinImmune systemNeuropeptide Y receptor
13Publications
6H-index
82Citations
Publications 13
Newest
#1Daisuke Morichika (Okayama University)H-Index: 8
#2Akihiko Taniguchi (Okayama University)H-Index: 10
Last. Masayuki Hanaoka (Shinshu University)H-Index: 28
view all 15 authors...
Background IL-33, which is known to induce type 2 immune responses via group 2 innate lymphoid cells, has been reported to contribute to neutrophilic airway inflammation in chronic obstructive pulmonary disease. However, its role in the pathogenesis of emphysema remains unclear. Methods We determined the role of interleukin (IL)-33 in the development of emphysema using porcine pancreas elastase (PPE) and cigarette smoke extract (CSE) in mice. First, IL-33-/- mice and wild-type (WT) mice were giv...
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#1Naohiro Oda (Okayama University)H-Index: 8
#2X. Nobuaki Miyahara (RMIT: RMIT University)H-Index: 1
Last. Yoshinobu Maeda (Okayama University)H-Index: 29
view all 11 authors...
Neuropeptide Y (NPY) is a neurotransmitter that is widely expressed in the brain and peripheral nervous system. Various immune cells express the NPY Y1 receptor. NPY modulates these cells via its Y...
7 CitationsSource
#1Akihiko Taniguchi (Okayama University)H-Index: 10
#2Naohiro Oda (Okayama University)H-Index: 8
Last. Nobuaki Miyahara (Okayama University)H-Index: 33
view all 10 authors...
Source
#1Daisuke Morichika (Okayama University)H-Index: 8
#2Nobuaki Miyahara (Okayama University)H-Index: 33
Last. Arihiko Kanehiro (Okayama University)H-Index: 25
view all 12 authors...
Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signalling by 9-cis retinoic acid, a vitamin A derivative. RXRs play key roles not only as homodimers but also as heterodimeric partners, e.g., for retinoic acid receptors, vitamin D receptors, and peroxisome proliferator-activated receptors. The NR family may also play important roles in the development of emphysema. However, the role of RXRs in the pathogenesis of emphysema is not well defined. We dev...
12 CitationsSource
#1Naohiro Oda (Okayama University)H-Index: 8
#2Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
Last. Arihiko Kanehiro (Okayama University)H-Index: 25
view all 10 authors...
11 CitationsSource
#1Akihiko TaniguchiH-Index: 10
#2Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
Last. Katsuyuki KiuraH-Index: 68
view all 12 authors...
Although recent retrospective studies suggested that the use of β-blockers appears to help improve the mortality rate and decrease the rate of exacerbation in chronic obstructive pulmonary disease (COPD) patients with heart failure, the effects of β-blockers on COPD patients without heart failure have not been established. Based on previous reports, we have launched a multicenter, prospective, single-arm phase II study to evaluate the preventive effect of the cardioselective β-blocker bisoprolol...
2 CitationsSource
#1Utako Fujii (Okayama University)H-Index: 6
#2Nobuaki Miyahara (Okayama University)H-Index: 33
Last. Arihiko Kanehiro (Okayama University)H-Index: 25
view all 12 authors...
Background Retinoid X receptors (RXRs) are members of the nuclear receptor (NR) superfamily that mediate signaling by 9-cis retinoic acid, a vitamin A (retinol) derivative. RXRs play key roles not only as homodimers but also as heterodimeric partners—e.g., retinoic acid receptors (RARs), vitamin D receptors (VDRs), liver X receptors (LXRs), and peroxisome proliferator-activated receptors (PPARs). The NR family was recently associated with allergic diseases, but the role of RXRs in allergen-induc...
14 CitationsSource
#1Utako FujiiH-Index: 6
#2Nobuaki Miyahara (Okayama University)H-Index: 33
Last. Arihiko KanehiroH-Index: 25
view all 13 authors...
We recently reported that IL-17A plays a critical role in the development of porcine pancreatic elastase (PPE)–induced emphysema. The proliferation of T-helper type 17 (Th17) cells was induced by IL-23. To determine the contribution of IL-23 to the development of pulmonary emphysema, a mouse model of PPE-induced emphysema was used in which responses of IL-23p19–deficient (IL-23−/−) and wild-type (WT) mice were compared. Intratracheal instillation of PPE induced emphysematous changes in the lungs...
11 CitationsSource
#1Utako Fujii (Okayama University)H-Index: 6
#2Nobuaki Miyahara (Okayama University)H-Index: 33
Last. Mitsune Tanimoto (Okayama University)H-Index: 68
view all 11 authors...
RATIONALE: We have recently reported that IL-17A plays a critical role to the development of porcine pancreatic elastase (PPE)-induced emphysema. The proliferation of Th17 cells is induced by IL-23, however, the role of IL-23 in pulmonary emphysema remains uncertain. METHODS: Using a murine model of PPE-induced pulmonary emphysema, we assessed IL-23p19-deficient (IL-23-/-) mice and wild type (WT) mice. Intra-tracheal instillation of PPE induced increased emphysematous change of the lungs on day ...
Source
#1Akihiko Taniguchi (Okayama University)H-Index: 10
#2Nobuaki Miyahara (RMIT: RMIT University)H-Index: 33
Last. Arihiko Kanehiro (Okayama University)H-Index: 25
view all 12 authors...
The receptor for advanced glycation end-products (RAGE) is a multiligand receptor that belongs to the immunoglobulin superfamily. RAGE is reported to be involved in various inflammatory disorders; however, studies that address the role of RAGE in allergic airway disease are inconclusive. RAGE-sufficient (RAGE+/+) and RAGE-deficient (RAGE−/−) mice were sensitized to ovalbumin, and airway responses were monitored after ovalbumin challenge. RAGE−/− mice showed reduced eosinophilic inflammation and ...
15 CitationsSource